Entry Database : EMDB / ID : EMD-40781 Downloads & linksTitle Caspase-1 complex with interleukin-18 Map datacaspase-1 in complex with interleukin-18 Details SampleComplex : protein complex with interleukinProtein or peptide : Caspase-1Protein or peptide : Caspase-1Protein or peptide : Interleukin-18 Details Keywords Innate immune / Complex / HYDROLASE / IMMUNE SYSTEMFunction / homology Function and homology informationFunction Domain/homology Component
interleukin-18 receptor binding / caspase-1 / protease inhibitor complex / AIM2 inflammasome complex assembly / The AIM2 inflammasome / Interleukin-18 signaling / positive regulation of tissue remodeling / The IPAF inflammasome / AIM2 inflammasome complex / IPAF inflammasome complex ... interleukin-18 receptor binding / caspase-1 / protease inhibitor complex / AIM2 inflammasome complex assembly / The AIM2 inflammasome / Interleukin-18 signaling / positive regulation of tissue remodeling / The IPAF inflammasome / AIM2 inflammasome complex / IPAF inflammasome complex / icosanoid biosynthetic process / NLRP1 inflammasome complex / positive regulation of T-helper 2 cell differentiation / positive regulation of T-helper 1 cell cytokine production / cytokine precursor processing / canonical inflammasome complex / positive regulation of interleukin-18 production / NLRP3 inflammasome complex / positive regulation of macrophage derived foam cell differentiation / CARD domain binding / caspase binding / positive regulation of interleukin-13 production / positive regulation of neuroinflammatory response / interleukin-18-mediated signaling pathway / natural killer cell mediated cytotoxicity / negative regulation of myoblast differentiation / type 2 immune response / natural killer cell activation / sleep / neutrophil activation / positive regulation of tumor necrosis factor-mediated signaling pathway / Interleukin-1 processing / osmosensory signaling pathway / positive regulation of NK T cell proliferation / Interleukin-37 signaling / triglyceride homeostasis / positive regulation of natural killer cell proliferation / positive regulation of granulocyte macrophage colony-stimulating factor production / pattern recognition receptor signaling pathway / T-helper 1 type immune response / : / signaling receptor ligand precursor processing / positive regulation of activated T cell proliferation / TP53 Regulates Transcription of Caspase Activators and Caspases / pyroptotic inflammatory response / positive regulation of interleukin-17 production / Interleukin-10 signaling / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / The NLRP3 inflammasome / protein autoprocessing / protein maturation / establishment of skin barrier / Pyroptosis / regulation of cell adhesion / Purinergic signaling in leishmaniasis infection / positive regulation of chemokine production / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of interleukin-1 beta production / cytokine activity / cholesterol homeostasis / positive regulation of smooth muscle cell proliferation / NOD1/2 Signaling Pathway / kinase binding / cellular response to type II interferon / positive regulation of inflammatory response / positive regulation of non-canonical NF-kappaB signal transduction / cellular response to mechanical stimulus / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of type II interferon production / cell-cell signaling / positive regulation of cold-induced thermogenesis / positive regulation of NF-kappaB transcription factor activity / regulation of inflammatory response / cellular response to lipopolysaccharide / regulation of apoptotic process / angiogenesis / Interleukin-4 and Interleukin-13 signaling / positive regulation of canonical NF-kappaB signal transduction / microtubule / defense response to virus / endopeptidase activity / cell population proliferation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / cysteine-type endopeptidase activity / apoptotic process / nucleolus / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / proteolysis / extracellular space / extracellular region / identical protein binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Interleukin-18 / Interleukin-1 family / Interleukin-1 / 18 / Caspase recruitment domain / Cytokine IL1/FGF / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. ... Interleukin-18 / Interleukin-1 family / Interleukin-1 / 18 / Caspase recruitment domain / Cytokine IL1/FGF / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Death-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method single particle reconstruction / cryo EM / Resolution : 3.5 Å Details AuthorsDong Y / Pascal D / Jon K / Wu H Funding support United States, 1 items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) United States
CitationJournal : To Be Published Title : Caspase-1 complex with interleukin-18Authors : Pascal D / Dong Y / Wu H / Jon K History Deposition May 15, 2023 - Header (metadata) release May 8, 2024 - Map release May 8, 2024 - Update May 8, 2024 - Current status May 8, 2024 Processing site : RCSB / Status : Released
Show all Show less