Entry Database : EMDB / ID : EMD-39795 Downloads & linksTitle Cryo-EM structure of the hGPR68-Gs complex in pH6.8 Map data Details SampleComplex : Cryo-EM structure of the hGPR68-Gs complex in pH6.8Protein or peptide : Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortProtein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Protein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Protein or peptide : scFv16Protein or peptide : Ovarian cancer G-protein coupled receptor 1 Details Keywords pH6.8 / hGPR68 / Gs / MEMBRANE PROTEIN/IMMUNE SYSTEM / MEMBRANE PROTEIN-IMMUNE SYSTEM complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of osteoclast development / cellular response to pH / negative regulation of monocyte differentiation / osteoclast development / Class A/1 (Rhodopsin-like receptors) / insulin secretion / monocyte differentiation / positive regulation of insulin secretion involved in cellular response to glucose stimulus / G protein-coupled receptor activity / Olfactory Signaling Pathway ... positive regulation of osteoclast development / cellular response to pH / negative regulation of monocyte differentiation / osteoclast development / Class A/1 (Rhodopsin-like receptors) / insulin secretion / monocyte differentiation / positive regulation of insulin secretion involved in cellular response to glucose stimulus / G protein-coupled receptor activity / Olfactory Signaling Pathway / Activation of the phototransduction cascade / G beta:gamma signalling through PLC beta / Presynaptic function of Kainate receptors / Thromboxane signalling through TP receptor / G protein-coupled acetylcholine receptor signaling pathway / G-protein activation / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Prostacyclin signalling through prostacyclin receptor / G beta:gamma signalling through CDC42 / Glucagon signaling in metabolic regulation / G beta:gamma signalling through BTK / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / ADP signalling through P2Y purinoceptor 12 / Sensory perception of sweet, bitter, and umami (glutamate) taste / photoreceptor disc membrane / Glucagon-type ligand receptors / Adrenaline,noradrenaline inhibits insulin secretion / Vasopressin regulates renal water homeostasis via Aquaporins / G alpha (z) signalling events / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / cellular response to catecholamine stimulus / ADP signalling through P2Y purinoceptor 1 / ADORA2B mediated anti-inflammatory cytokines production / G beta:gamma signalling through PI3Kgamma / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / adenylate cyclase-activating dopamine receptor signaling pathway / GPER1 signaling / Inactivation, recovery and regulation of the phototransduction cascade / cellular response to prostaglandin E stimulus / G-protein beta-subunit binding / heterotrimeric G-protein complex / G alpha (12/13) signalling events / sensory perception of taste / extracellular vesicle / signaling receptor complex adaptor activity / Thrombin signalling through proteinase activated receptors (PARs) / retina development in camera-type eye / GTPase binding / Ca2+ pathway / fibroblast proliferation / High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells / G alpha (i) signalling events / G alpha (s) signalling events / phospholipase C-activating G protein-coupled receptor signaling pathway / G alpha (q) signalling events / Ras protein signal transduction / Extra-nuclear estrogen signaling / cell population proliferation / G protein-coupled receptor signaling pathway / inflammatory response / lysosomal membrane / GTPase activity / synapse / protein-containing complex binding / signal transduction / extracellular exosome / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function OGR1 sphingosylphosphorylcholine receptor / G-protein, gamma subunit / G-protein gamma subunit domain profile. / G-protein gamma-like domain / G-protein gamma-like domain superfamily / GGL domain / G protein gamma subunit-like motifs / GGL domain / G protein beta WD-40 repeat protein / Guanine nucleotide-binding protein, beta subunit ... OGR1 sphingosylphosphorylcholine receptor / G-protein, gamma subunit / G-protein gamma subunit domain profile. / G-protein gamma-like domain / G-protein gamma-like domain superfamily / GGL domain / G protein gamma subunit-like motifs / GGL domain / G protein beta WD-40 repeat protein / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily Similarity search - Domain/homology Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 / Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 / G-protein coupled receptor 68 Similarity search - ComponentBiological species Homo sapiens (human) / synthetic construct (others) Method single particle reconstruction / cryo EM / Resolution : 2.64 Å Details AuthorsZhong YN / Guo LL / Yang F / Sun JP Funding support China, 1 items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 81773704 China
CitationJournal : To Be Published Title : Cryo-EM structure of the hGPR68-Gs complex in pH6.8Authors : Zhong YN / Guo LL / Yang F / Sun JP History Deposition Apr 18, 2024 - Header (metadata) release Apr 23, 2025 - Map release Apr 23, 2025 - Update Apr 23, 2025 - Current status Apr 23, 2025 Processing site : PDBc / Status : Released
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