登録情報 | データベース: EMDB / ID: EMD-36338 |
---|
タイトル | Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in one fab conformation |
---|
マップデータ | |
---|
試料 | - 細胞: Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab28
- タンパク質・ペプチド: Glutamate receptor ionotropic, NMDA 2A
- タンパク質・ペプチド: Glutamate receptor ionotropic, NMDA 1
- タンパク質・ペプチド: Fab2G7 Heavy Chain
- タンパク質・ペプチド: Fab2G7 Light Chain
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
|
---|
キーワード | NMDAR / autoimmune encephalitis / MEMBRANE PROTEIN |
---|
機能・相同性 | 機能・相同性情報
excitatory chemical synaptic transmission / directional locomotion / Synaptic adhesion-like molecules / serotonin metabolic process / protein localization to postsynaptic membrane / propylene metabolic process / response to glycine / sleep / activation of cysteine-type endopeptidase activity / regulation of monoatomic cation transmembrane transport ...excitatory chemical synaptic transmission / directional locomotion / Synaptic adhesion-like molecules / serotonin metabolic process / protein localization to postsynaptic membrane / propylene metabolic process / response to glycine / sleep / activation of cysteine-type endopeptidase activity / regulation of monoatomic cation transmembrane transport / glutamate receptor signaling pathway / Assembly and cell surface presentation of NMDA receptors / NMDA glutamate receptor activity / Neurexins and neuroligins / NMDA selective glutamate receptor complex / glutamate-gated calcium ion channel activity / calcium ion transmembrane import into cytosol / protein heterotetramerization / glutamate binding / positive regulation of reactive oxygen species biosynthetic process / glycine binding / positive regulation of calcium ion transport into cytosol / dopamine metabolic process / Negative regulation of NMDA receptor-mediated neuronal transmission / startle response / Unblocking of NMDA receptors, glutamate binding and activation / monoatomic cation transmembrane transport / monoatomic cation transport / regulation of neuronal synaptic plasticity / positive regulation of excitatory postsynaptic potential / ligand-gated monoatomic ion channel activity / Long-term potentiation / excitatory synapse / calcium ion homeostasis / synaptic cleft / MECP2 regulates neuronal receptors and channels / sensory perception of pain / response to amphetamine / EPHB-mediated forward signaling / ionotropic glutamate receptor signaling pathway / Ras activation upon Ca2+ influx through NMDA receptor / excitatory postsynaptic potential / positive regulation of synaptic transmission, glutamatergic / neurogenesis / synaptic membrane / synaptic transmission, glutamatergic / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / regulation of membrane potential / long-term synaptic potentiation / postsynaptic density membrane / protein catabolic process / visual learning / regulation of synaptic plasticity / cytoplasmic vesicle membrane / negative regulation of protein catabolic process / brain development / terminal bouton / memory / response to wounding / synaptic vesicle / presynaptic membrane / signaling receptor activity / amyloid-beta binding / RAF/MAP kinase cascade / chemical synaptic transmission / postsynaptic membrane / response to ethanol / dendritic spine / postsynaptic density / learning or memory / calmodulin binding / response to xenobiotic stimulus / neuron projection / positive regulation of apoptotic process / glutamatergic synapse / synapse / calcium ion binding / dendrite / protein-containing complex binding / endoplasmic reticulum membrane / cell surface / positive regulation of transcription by RNA polymerase II / zinc ion binding / plasma membrane / cytoplasm類似検索 - 分子機能 Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel ...Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I類似検索 - ドメイン・相同性 Glutamate receptor ionotropic, NMDA 1 / Glutamate receptor ionotropic, NMDA 2A類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 4.3 Å |
---|
データ登録者 | Wang H / Zhu S |
---|
資金援助 | 中国, 5件 Organization | Grant number | 国 |
---|
Other government | 2022ZD0212700 | 中国 | Other government | LG 202106-02 | 中国 | Other government | 2017YFA0505700 | 中国 | Other government | XDBS01020000 | 中国 | Other government | 2018SHZDZX05 | 中国 |
|
---|
引用 | ジャーナル: To Be Published タイトル: Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab23 著者: Wang H |
---|
履歴 | 登録 | 2023年5月29日 | - |
---|
ヘッダ(付随情報) 公開 | 2024年6月5日 | - |
---|
マップ公開 | 2024年6月5日 | - |
---|
更新 | 2024年6月5日 | - |
---|
現状 | 2024年6月5日 | 処理サイト: PDBj / 状態: 公開 |
---|
|
---|