登録情報 | データベース: EMDB / ID: EMD-35836 |
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タイトル | cryo-EM structure of PGE1-bound hMRP4 |
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マップデータ | |
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試料 | - 複合体: PGE1-bound hMRP4
- タンパク質・ペプチド: ATP-binding cassette sub-family C member 4
- リガンド: 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid
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キーワード | cryo-EM structure of PGE1-bound hMRP4 / MEMBRANE PROTEIN |
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機能・相同性 | 機能・相同性情報
guanine nucleotide transmembrane transporter activity / 15-hydroxyprostaglandin dehydrogenase (NAD+) activity / purine nucleotide transmembrane transporter activity / cAMP transport / urate transport / ABC-type bile acid transporter activity / platelet dense granule membrane / leukotriene transport / prostaglandin transport / prostaglandin transmembrane transporter activity ...guanine nucleotide transmembrane transporter activity / 15-hydroxyprostaglandin dehydrogenase (NAD+) activity / purine nucleotide transmembrane transporter activity / cAMP transport / urate transport / ABC-type bile acid transporter activity / platelet dense granule membrane / leukotriene transport / prostaglandin transport / prostaglandin transmembrane transporter activity / glutathione transmembrane transporter activity / ABC-type glutathione-S-conjugate transporter / ABC-type glutathione S-conjugate transporter activity / urate transmembrane transporter activity / platelet degranulation / ATPase-coupled inorganic anion transmembrane transporter activity / external side of apical plasma membrane / xenobiotic transmembrane transport / export across plasma membrane / prostaglandin secretion / ABC-type xenobiotic transporter / Paracetamol ADME / bile acid and bile salt transport / ABC-type xenobiotic transporter activity / トランスロカーゼ; 他の化合物の輸送を触媒; ヌクレオシド三リン酸の加水分解に伴う / Azathioprine ADME / efflux transmembrane transporter activity / xenobiotic transmembrane transporter activity / transport across blood-brain barrier / cilium assembly / ATPase-coupled transmembrane transporter activity / ABC-type transporter activity / xenobiotic metabolic process / ABC-family proteins mediated transport / transmembrane transport / Platelet degranulation / basolateral plasma membrane / apical plasma membrane / nucleolus / Golgi apparatus / ATP hydrolysis activity / ATP binding / membrane / plasma membrane類似検索 - 分子機能 ATP-binding cassette sub-family C member 4 / : / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain ...ATP-binding cassette sub-family C member 4 / : / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain / ATP-binding cassette, ABC transporter-type domain profile. / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.95 Å |
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データ登録者 | Liu ZM / Huang Y |
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資金援助 | 中国, 1件 Organization | Grant number | 国 |
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National Science Foundation (NSF, China) | | 中国 |
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引用 | ジャーナル: To Be Published タイトル: cryo-EM structure of PGE1-bound hMRP4 著者: Liu ZM / Huang Y |
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履歴 | 登録 | 2023年4月6日 | - |
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ヘッダ(付随情報) 公開 | 2024年4月10日 | - |
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マップ公開 | 2024年4月10日 | - |
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更新 | 2024年4月10日 | - |
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現状 | 2024年4月10日 | 処理サイト: PDBc / 状態: 公開 |
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