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- EMDB-35712: human RNA polymerase III pre-initiation complex closed DNA 1 -

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Open data

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Basic information

Entry

Database: EMDB / ID: EMD-35712

Title

human RNA polymerase III pre-initiation complex closed DNA 1

Map data

closed complex 1

Sample

Complex: RNA polymerase III pre-initiation complex closed complex 1
- Complex: RNA polymerase III pre-initiation complex closed complex 1
  - Protein or peptide: x 20 types
- Complex: RNA polymerase III pre-initiation complex closed complex 1
  - Protein or peptide: x 3 types
- Complex: DNA
  - DNA: x 2 types
Ligand: x 3 types

Keywords

RNA polymerase III / SNAPc complex / TRANSCRIPTION

Function / homology

Function and homology information

transcription preinitiation complex assembly / snRNA-activating protein complex / snRNA transcription / snRNA transcription by RNA polymerase III / bent DNA binding / RNA Polymerase III Chain Elongation / RNA Polymerase III Transcription Termination / calcitonin gene-related peptide receptor activity / DNA/RNA hybrid binding / transcription factor TFIIIB complex ...transcription preinitiation complex assembly / snRNA-activating protein complex / snRNA transcription / snRNA transcription by RNA polymerase III / bent DNA binding / RNA Polymerase III Chain Elongation / RNA Polymerase III Transcription Termination / calcitonin gene-related peptide receptor activity / DNA/RNA hybrid binding / transcription factor TFIIIB complex / RNA polymerase III preinitiation complex assembly / TFIIIC-class transcription factor complex binding / RNA polymerase III type 3 promoter sequence-specific DNA binding / RPAP3/R2TP/prefoldin-like complex / snRNA transcription by RNA polymerase II / regulation of transcription by RNA polymerase I / RNA polymerase III general transcription initiation factor activity / RNA polymerase transcription factor SL1 complex / regulation of transcription by RNA polymerase III / DNA polymerase III complex / RNA polymerase I core promoter sequence-specific DNA binding / Cytosolic sensors of pathogen-associated DNA / RNA Polymerase III Transcription Initiation From Type 1 Promoter / RNA Polymerase III Transcription Initiation From Type 2 Promoter / RNA Polymerase III Transcription Initiation From Type 3 Promoter / RNA Polymerase III Abortive And Retractive Initiation / transcription factor TFIIA complex / female germ cell nucleus / positive regulation of innate immune response / male pronucleus / female pronucleus / Abortive elongation of HIV-1 transcript in the absence of Tat / nucleobase-containing compound metabolic process / RNA polymerase II general transcription initiation factor binding / MicroRNA (miRNA) biogenesis / transcription preinitiation complex / FGFR2 alternative splicing / RNA Polymerase I Transcription Termination / Viral Messenger RNA Synthesis / Signaling by FGFR2 IIIa TM / RNA Pol II CTD phosphorylation and interaction with CE during HIV infection / RNA Pol II CTD phosphorylation and interaction with CE / Formation of the Early Elongation Complex / Formation of the HIV-1 Early Elongation Complex / termination of RNA polymerase III transcription / mRNA Capping / PIWI-interacting RNA (piRNA) biogenesis / HIV Transcription Initiation / RNA Polymerase II HIV Promoter Escape / Transcription of the HIV genome / RNA Polymerase II Promoter Escape / RNA Polymerase II Transcription Pre-Initiation And Promoter Opening / RNA Polymerase II Transcription Initiation / RNA Polymerase II Transcription Initiation And Promoter Clearance / transcription initiation at RNA polymerase III promoter / mRNA Splicing - Minor Pathway / RNA Polymerase I Transcription Initiation / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / transcription by RNA polymerase I / aryl hydrocarbon receptor binding / transcription by RNA polymerase III / Processing of Capped Intron-Containing Pre-mRNA / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / RNA polymerase II transcribes snRNA genes / transcription factor TFIID complex / TFIIB-class transcription factor binding / RNA polymerase II general transcription initiation factor activity / neuropeptide signaling pathway / transcription elongation by RNA polymerase I / Tat-mediated elongation of the HIV-1 transcript / positive regulation of transcription initiation by RNA polymerase II / RNA polymerase II core promoter sequence-specific DNA binding / Formation of HIV-1 elongation complex containing HIV-1 Tat / RNA polymerase I complex / RNA polymerase III complex / Formation of HIV elongation complex in the absence of HIV Tat / RNA polymerase III activity / RNA polymerase II, core complex / tRNA transcription by RNA polymerase III / RNA polymerase I activity / RNA Polymerase II Transcription Elongation / RNA polymerase II activity / Formation of RNA Pol II elongation complex / core promoter sequence-specific DNA binding / RNA polymerase II preinitiation complex assembly / RNA Polymerase II Pre-transcription Events / Inhibition of DNA recombination at telomere / TBP-class protein binding / positive regulation of interferon-beta production / mRNA Splicing - Major Pathway / acrosomal vesicle / SIRT1 negatively regulates rRNA expression / male germ cell nucleus / DNA-templated transcription initiation / transcription initiation at RNA polymerase II promoter / RNA Polymerase I Promoter Escape / TP53 Regulates Transcription of DNA Repair Genes / protein-DNA complex
Similarity search - Function

snRNA-activating protein complex subunit 1 / snRNA-activating protein complex, subunit 3 / Small nuclear RNA activating complex (SNAPc), subunit 1 / snRNA-activating protein complex (SNAPc), subunit 3 / Transcription factor TFIIIB component B'', Myb domain / Myb DNA-binding like / DNA-directed RNA polymerase III subunit RPC5, C-terminal / DNA-directed RNA polymerase III subunit RPC5 C-terminal / Myb-like domain profile. / DNA-directed RNA polymerase III, subunit Rpc31 ...snRNA-activating protein complex subunit 1 / snRNA-activating protein complex, subunit 3 / Small nuclear RNA activating complex (SNAPc), subunit 1 / snRNA-activating protein complex (SNAPc), subunit 3 / Transcription factor TFIIIB component B'', Myb domain / Myb DNA-binding like / DNA-directed RNA polymerase III subunit RPC5, C-terminal / DNA-directed RNA polymerase III subunit RPC5 C-terminal / Myb-like domain profile. / DNA-directed RNA polymerase III, subunit Rpc31 / DNA-directed RNA polymerase III subunit Rpc31 / Pol III subunit C11, C-terminal zinc ribbon / DNA-directed RNA polymerase III subunit Rpc5 / DNA-directed RNA polymerase III subunit RPC1, N-terminal / DNA-directed RNA polymerase III subunit RPC1, C-terminal / RPC5 protein / RNA polymerase III, subunit Rpc25 / DNA-directed RNA polymerase III subunit RPC9 / RNA polymerase III subunit Rpc25 / RNA polymerase Rpc34 / RNA polymerase III Rpc82, C -terminal / RNA polymerase Rpc34-like / DNA-directed RNA polymerase III subunit RPC3 / RNA polymerase Rpc34 subunit / RNA polymerase III subunit RPC82 / DNA-directed RNA polymerase III subunit RPC3, helical hairpin domain / RNA polymerase III subunit RPC82-related, helix-turn-helix / RNA polymerase III subunit RPC82 helix-turn-helix domain / Myb-like DNA-binding domain / DNA-directed RNA polymerase, subunit E/RPC8 / DNA-directed RNA polymerases I and III subunit AC19 / DNA-directed RNA polymerases I and III subunit AC40 / Transcription factor TFIIB / Zinc finger TFIIB-type profile. / Myb-type HTH DNA-binding domain profile. / Zinc finger, TFIIB-type / TFIIB zinc-binding / SANT domain / TATA-box binding protein, eukaryotic / TATA-box binding protein / TATA-box binding protein, conserved site / Transcription factor TFIID (or TATA-binding protein, TBP) / Transcription factor TFIID repeat signature. / Myb domain / TBP domain superfamily / RNA polymerase Rpb4/RPC9, core / DNA-directed RNA-polymerase II subunit / Rpb4/RPC9 superfamily / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / RNA polymerase subunit Rpb4/RPC9 / RNA polymerase Rpb4 / Cyclin-like superfamily / Zinc finger TFIIS-type signature. / RNA polymerase subunit Rpb7-like / RNA polymerase Rpb7-like , N-terminal / RNA polymerase Rpb7-like, N-terminal domain superfamily / SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 / HRDC-like superfamily / RNA polymerase Rpb2, domain 4 / RNA polymerase Rpb2, domain 4 / RNA polymerase Rpb2, domain 5 / RNA polymerase Rpb2, domain 5 / DNA-directed RNA polymerase, M/15kDa subunit / RNA polymerases M/15 Kd subunit / RNA polymerase subunit 9 / DNA-directed RNA polymerase subunit RPABC5/Rpb10 / RNA polymerases, subunit N, zinc binding site / RNA polymerase subunit RPB10 / RNA polymerases N / 8 kDa subunit / RNA polymerases N / 8 Kd subunits signature. / DNA-directed RNA polymerase M, 15kDa subunit, conserved site / RNA polymerases M / 15 Kd subunits signature. / DNA-directed RNA polymerase subunit/transcription factor S / RNA polymerase, Rpb8 / DNA-directed RNA polymerases I, II, and III subunit RPABC4 / RNA polymerase Rpb8 / RNA polymerase subunit 8 / RNA polymerase, Rpb5, N-terminal / RNA polymerase Rpb5, N-terminal domain superfamily / RNA polymerase Rpb5, N-terminal domain / DNA-directed RNA polymerase, subunit RPB6 / DNA directed RNA polymerase, 7 kDa subunit / DNA-directed RNA polymerase subunit Rpo11 / RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4 / RNA polymerase, subunit H/Rpb5, conserved site / RNA polymerases H / 23 Kd subunits signature. / RNA polymerase subunit CX / DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site / DNA-directed RNA polymerase subunit Rpo5/Rpb5 / RNA polymerases L / 13 to 16 Kd subunits signature. / DNA-directed RNA polymerase, 30-40kDa subunit, conserved site / DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1 / RNA polymerases D / 30 to 40 Kd subunits signature. / DNA-directed RNA polymerase, RBP11-like dimerisation domain / RNA polymerase Rpb3/Rpb11 dimerisation domain / RNA polymerase, subunit H/Rpb5 C-terminal / RNA polymerase subunit RPABC4/transcription elongation factor Spt4 / RPB5-like RNA polymerase subunit superfamily / RNA polymerase Rpb5, C-terminal domain
Similarity search - Domain/homology

Biological species

Homo sapiens (human)

Method

single particle reconstruction / cryo EM / Resolution: 3.9 Å

Authors

Hou H / Jin Q / Ren Y / Wang Q / Xu Y

Funding support

China, 1 items

Citation

Journal: Cell Res / Year: 2023
Title: Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Authors: Haifeng Hou / Qianwei Jin / Yulei Ren / Zhenguo Chen / Qianmin Wang / Yanhui Xu /

History

Deposition	Mar 23, 2023	-
Header (metadata) release	Jun 7, 2023	-
Map release	Jun 7, 2023	-
Update	Jul 12, 2023	-
Current status	Jul 12, 2023	Processing site: PDBj / Status: Released

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Structure visualization

Supplemental images	emd_35712.png

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Downloads & links

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EMDB archive

Map data	emd_35712.map.gz	113.4 MB		EMDB map data format
Header (meta data)	emd-35712-v30.xml emd-35712.xml	59.9 KB 59.9 KB	Display Display	EMDB header
Images	emd_35712.png	120.5 KB
Others	emd_35712_additional_1.map.gz emd_35712_half_map_1.map.gz emd_35712_half_map_2.map.gz	56.2 MB 98.5 MB 98.6 MB
Archive directory	http://ftp.pdbj.org/pub/emdb/structures/EMD-35712 ftp://ftp.pdbj.org/pub/emdb/structures/EMD-35712	HTTPS FTP

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Validation report

Summary document	emd_35712_validation.pdf.gz	1 MB	Display	EMDB validaton report
Full document	emd_35712_full_validation.pdf.gz	1 MB	Display
Data in XML	emd_35712_validation.xml.gz	13.7 KB	Display
Data in CIF	emd_35712_validation.cif.gz	16.2 KB	Display
Arichive directory	https://ftp.pdbj.org/pub/emdb/validation_reports/EMD-35712 ftp://ftp.pdbj.org/pub/emdb/validation_reports/EMD-35712	HTTPS FTP

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Related structure data

Related structure data	8ityMC 35715C 35716C 35717C 35718C 35719C 35722C 8iueC 8iuhC M: atomic model generated by this map C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

EMDB pages	EMDB (EBI/PDBe) / EMDataResource
Related items in Molecule of the Month	#67 - Jul 2005 TATA-Binding Protein similarity (30) #255 - Mar 2021 Cisplatin and DNA similarity (58) #40 - Apr 2003 RNA Polymerase similarity (47) #23 - Nov 2001 DNA similarity (1) #240 - Dec 2019 Hypoxia-Inducible Factors similarity (11) #112 - Apr 2009 Oct and Sox Transcription Factors similarity (3) #48 - Dec 2003 Catabolite Activator Protein similarity (2) #205 - Jan 2017 Nuclear Pore Complex similarity (3) #88 - Apr 2007 Clathrin similarity (1) #245 - May 2020 Spliceosomes similarity (4) #241 - Jan 2020 Twenty Years of Molecules similarity (60) #236 - Aug 2019 Cyclin and Cyclin-dependent Kinase similarity (1) #55 - Jul 2004 DNA Ligase similarity (1) #98 - Feb 2008 Small Interfering RNA similarity (2) #31 - Jul 2002 p53 Tumor Suppressor similarity (1) #213 - Sep 2017 Sirtuins similarity (2) #130 - Oct 2010 Riboswitches similarity (1) #122 - Feb 2010 Enhanceosome similarity (1) #47 - Nov 2003 Simian Virus 40 similarity (1) #65 - May 2005 Self-splicing RNA similarity (1) #221 - May 2018 Human Papillomavirus and Vaccines similarity (1) #234 - Jun 2019 MDM2 and Cancer similarity (1)

EMDB pages

EMDB (EBI/PDBe) /

EMDataResource

Related items in Molecule of the Month

#67 - Jul 2005
TATA-Binding Protein
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Cisplatin and DNA
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RNA Polymerase
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#23 - Nov 2001
DNA
similarity (1)
#240 - Dec 2019
Hypoxia-Inducible Factors
similarity (11)
#112 - Apr 2009
Oct and Sox Transcription Factors
similarity (3)
#48 - Dec 2003
Catabolite Activator Protein
similarity (2)
#205 - Jan 2017
Nuclear Pore Complex
similarity (3)
#88 - Apr 2007
Clathrin
similarity (1)
#245 - May 2020
Spliceosomes
similarity (4)
#241 - Jan 2020
Twenty Years of Molecules
similarity (60)
#236 - Aug 2019
Cyclin and Cyclin-dependent Kinase
similarity (1)
#55 - Jul 2004
DNA Ligase
similarity (1)
#98 - Feb 2008
Small Interfering RNA
similarity (2)
#31 - Jul 2002
p53 Tumor Suppressor
similarity (1)
#213 - Sep 2017
Sirtuins
similarity (2)
#130 - Oct 2010
Riboswitches
similarity (1)
#122 - Feb 2010
Enhanceosome
similarity (1)
#47 - Nov 2003
Simian Virus 40
similarity (1)
#65 - May 2005
Self-splicing RNA
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Human Papillomavirus and Vaccines
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MDM2 and Cancer
similarity (1)

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Map

File

Download / File: emd_35712.map.gz / Format: CCP4 / Size: 125 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)

Annotation

closed complex 1

Voxel size

X=Y=Z: 1.334 Å

Density

Contour Level	By AUTHOR: 0.02
Minimum - Maximum	-0.01980023 - 0.08662399
Average (Standard dev.)	-0.000026682037 (±0.0034537006)

Symmetry

Space group: 1

Details

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Supplemental data

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Additional map: TFIIIB-SNAPC masked

File

emd_35712_additional_1.map

Annotation

TFIIIB-SNAPC masked

Projections & Slices

Axes	Z	Y	X
Projections
Slices (1/2)

Density Histograms

Histogram

Histogram (log scale)

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Half map: half map1

File

emd_35712_half_map_1.map

Annotation

half map1

Projections & Slices

Axes	Z	Y	X
Projections
Slices (1/2)

Density Histograms

Histogram

Histogram (log scale)

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Half map: half map2

File

emd_35712_half_map_2.map

Annotation

half map2

Projections & Slices

Axes	Z	Y	X
Projections
Slices (1/2)

Density Histograms

Histogram

Histogram (log scale)

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Sample components

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Entire : RNA polymerase III pre-initiation complex closed complex 1

Entire	Name: RNA polymerase III pre-initiation complex closed complex 1
Components	Complex: RNA polymerase III pre-initiation complex closed complex 1 Complex: RNA polymerase III pre-initiation complex closed complex 1 Protein or peptide: DNA-directed RNA polymerase III subunit RPC1 Protein or peptide: DNA-directed RNA polymerase III subunit RPC2 Protein or peptide: DNA-directed RNA polymerases I and III subunit RPAC1 Protein or peptide: DNA-directed RNA polymerase III subunit RPC9 Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC1 Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC2 Protein or peptide: DNA-directed RNA polymerase III subunit RPC8 Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC3 Protein or peptide: DNA-directed RNA polymerase III subunit RPC10 Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC5 Protein or peptide: DNA-directed RNA polymerases I and III subunit RPAC2 Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC4 Protein or peptide: DNA-directed RNA polymerase III subunit RPC5 Protein or peptide: DNA-directed RNA polymerase III subunit RPC4 Protein or peptide: DNA-directed RNA polymerase III subunit RPC3 Protein or peptide: DNA-directed RNA polymerase III subunit RPC6 Protein or peptide: DNA-directed RNA polymerase III subunit RPC7 Protein or peptide: snRNA-activating protein complex subunit 1 Protein or peptide: snRNA-activating protein complex subunit 3 Protein or peptide: snRNA-activating protein complex subunit 4 Complex: RNA polymerase III pre-initiation complex closed complex 1 Protein or peptide: TATA-box-binding protein Protein or peptide: Transcription factor IIIB 50 kDa subunit Protein or peptide: Transcription factor TFIIIB component B'' homolog Complex: DNA DNA: DNA (82-MER) DNA: DNA (82-MER) Ligand: ZINC ION Ligand: MAGNESIUM ION Ligand: IRON/SULFUR CLUSTER

Entire

Name: RNA polymerase III pre-initiation complex closed complex 1

Components

Complex: RNA polymerase III pre-initiation complex closed complex 1
- Complex: RNA polymerase III pre-initiation complex closed complex 1
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC1
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC2
  - Protein or peptide: DNA-directed RNA polymerases I and III subunit RPAC1
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC9
  - Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC1
  - Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC2
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC8
  - Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC3
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC10
  - Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC5
  - Protein or peptide: DNA-directed RNA polymerases I and III subunit RPAC2
  - Protein or peptide: DNA-directed RNA polymerases I, II, and III subunit RPABC4
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC5
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC4
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC3
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC6
  - Protein or peptide: DNA-directed RNA polymerase III subunit RPC7
  - Protein or peptide: snRNA-activating protein complex subunit 1
  - Protein or peptide: snRNA-activating protein complex subunit 3
  - Protein or peptide: snRNA-activating protein complex subunit 4
- Complex: RNA polymerase III pre-initiation complex closed complex 1
  - Protein or peptide: TATA-box-binding protein
  - Protein or peptide: Transcription factor IIIB 50 kDa subunit
  - Protein or peptide: Transcription factor TFIIIB component B'' homolog
- Complex: DNA
  - DNA: DNA (82-MER)
  - DNA: DNA (82-MER)
Ligand: ZINC ION
Ligand: MAGNESIUM ION
Ligand: IRON/SULFUR CLUSTER

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Supramolecule #1: RNA polymerase III pre-initiation complex closed complex 1

Supramolecule	Name: RNA polymerase III pre-initiation complex closed complex 1 type: complex / ID: 1 / Parent: 0 / Macromolecule list: #4-#20, #1-#3, #21-#25
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 1 MDa

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Supramolecule #2: RNA polymerase III pre-initiation complex closed complex 1

Supramolecule	Name: RNA polymerase III pre-initiation complex closed complex 1 type: complex / ID: 2 / Parent: 1 / Macromolecule list: #4-#20, #1-#3

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Supramolecule #3: RNA polymerase III pre-initiation complex closed complex 1

Supramolecule	Name: RNA polymerase III pre-initiation complex closed complex 1 type: complex / ID: 3 / Parent: 1 / Macromolecule list: #21-#23

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Supramolecule #4: DNA

Supramolecule	Name: DNA / type: complex / ID: 4 / Parent: 1 / Macromolecule list: #24-#25

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Macromolecule #1: snRNA-activating protein complex subunit 1

Macromolecule	Name: snRNA-activating protein complex subunit 1 / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 43.074473 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQ LCQPKQKIRV ALKDWDEVLK FQQDLVNAQH FDAAYIFRKL RLDRAFHFTA MPKLLSYRMK KKIHRAEVTE E FKDPSDRV ...String: MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQ LCQPKQKIRV ALKDWDEVLK FQQDLVNAQH FDAAYIFRKL RLDRAFHFTA MPKLLSYRMK KKIHRAEVTE E FKDPSDRV MKLITSDVLE EMLNVHDHYQ NMKHVISVDK SKPDKALSLI KDDFFDNIKN IVLEHQQWHK DRKNPSLKSK TN DGEEKME GNSQETERCE RAESLAKIKS KAFSVVIQAS KSRRHRQVKL DSSDSDSASG QGQVKATRKK EKKERLKPAG RKM SLRNKG NVQNIHKEDK PLSLSMPVIT EEEENESLSG TEFTASKKRR KH UniProtKB: snRNA-activating protein complex subunit 1

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Macromolecule #2: snRNA-activating protein complex subunit 3

Macromolecule	Name: snRNA-activating protein complex subunit 3 / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 46.812605 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL WRGRLRGAGD LSLREPPASA LPGSQAADSD REDAAVARD LDCSLEAAAE LRAVCGLDKL KCLEDGEDPE VIPENTDLVT LGVRKRFLEH REETITIDRA CRQETFVYEM E SHAIGKKP ...String: MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL WRGRLRGAGD LSLREPPASA LPGSQAADSD REDAAVARD LDCSLEAAAE LRAVCGLDKL KCLEDGEDPE VIPENTDLVT LGVRKRFLEH REETITIDRA CRQETFVYEM E SHAIGKKP ENSADMIEEG ELILSVNILY PVIFHKHKEH KPYQTMLVLG SQKLTQLRDS IRCVSDLQIG GEFSNTPDQA PE HISKDLY KSAFFYFEGT FYNDKRYPEC RDLSRTIIEW SESHDRGYGK FQTARMEDFT FNDLCIKLGF PYLYCHQGDC EHV IVITDI RLVHHDDCLD RTLYPLLIKK HWLWTRKCFV CKMYTARWVT NNDSFAPEDP CFFCDVCFRM LHYDSEGNKL GEFL AYPYV DPGTFN UniProtKB: snRNA-activating protein complex subunit 3

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Macromolecule #3: snRNA-activating protein complex subunit 4

Macromolecule	Name: snRNA-activating protein complex subunit 4 / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 159.645172 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MDVDAEREKI TQEIKELERI LDPGSSGSHV EISESSLESD SEADSLPSED LDPADPPISE EERWGEASND EDDPKDKTLP EDPETCLQL NMVYQEVIQE KLAEANLLLA QNREQQEELM RDLAGSKGTK VKDGKSLPPS TYMGHFMKPY FKDKVTGVGP P ANEDTREK ...String: MDVDAEREKI TQEIKELERI LDPGSSGSHV EISESSLESD SEADSLPSED LDPADPPISE EERWGEASND EDDPKDKTLP EDPETCLQL NMVYQEVIQE KLAEANLLLA QNREQQEELM RDLAGSKGTK VKDGKSLPPS TYMGHFMKPY FKDKVTGVGP P ANEDTREK AAQGIKAFEE LLVTKWKNWE KALLRKSVVS DRLQRLLQPK LLKLEYLHQK QSKVSSELER QALEKQGREA EK EIQDINQ LPEEALLGNR LDSHDWEKIS NINFEGSRSA EEIRKFWQNS EHPSINKQEW SREEEERLQA IAAAHGHLEW QKI AEELGT SRSAFQCLQK FQQHNKALKR KEWTEEEDRM LTQLVQEMRV GSHIPYRRIV YYMEGRDSMQ LIYRWTKSLD PGLK KGYWA PEEDAKLLQA VAKYGEQDWF KIREEVPGRS DAQCRDRYLR RLHFSLKKGR WNLKEEEQLI ELIEKYGVGH WAKIA SELP HRSGSQCLSK WKIMMGKKQG LRRRRRRARH SVRWSSTSSS GSSSGSSGGS SSSSSSSSEE DEPEQAQAGE GDRALL SPQ YMVPDMDLWV PARQSTSQPW RGGAGAWLGG PAASLSPPKG SSASQGGSKE ASTTAAAPGE ETSPVQVPAR AHGPVPR SA QASHSADTRP AGAEKQALEG GRRLLTVPVE TVLRVLRANT AARSCTQKEQ LRQPPLPTSS PGVSSGDSVA RSHVQWLR H RATQSGQRRW RHALHRRLLN RRLLLAVTPW VGDVVVPCTQ ASQRPAVVQT QADGLREQLQ QARLASTPVF TLFTQLFHI DTAGCLEVVR ERKALPPRLP QAGARDPPVH LLQASSSAQS TPGHLFPNVP AQEASKSASH KGSRRLASSR VERTLPQASL LASTGPRPK PKTVSELLQE KRLQEARARE ATRGPVVLPS QLLVSSSVIL QPPLPHTPHG RPAPGPTVLN VPLSGPGAPA A AKPGTSGS WQEAGTSAKD KRLSTMQALP LAPVFSEAEG TAPAASQAPA LGPGQISVSC PESGLGQSQA PAASRKQGLP EA PPFLPAA PSPTPLPVQP LSLTHIGGPH VATSVPLPVT WVLTAQGLLP VPVPAVVSLP RPAGTPGPAG LLATLLPPLT ETR AAQGPR APALSSSWQP PANMNREPEP SCRTDTPAPP THALSQSPAE ADGSVAFVPG EAQVAREIPE PRTSSHADPP EAEP PWSGR LPAFGGVIPA TEPRGTPGSP SGTQEPRGPL GLEKLPLRQP GPEKGALDLE KPPLPQPGPE KGALDLGLLS QEGEA ATQQ WLGGQRGVRV PLLGSRLPYQ PPALCSLRAL SGLLLHKKAL EHKATSLVVG GEAERPAGAL QASLGLVRGQ LQDNPA YLL LRARFLAAFT LPALLATLAP QGVRTTLSVP SRVGSESEDE DLLSELELAD RDGQPGCTTA TCPIQGAPDS GKCSASS CL DTSNDPDDLD VLRTRHARHT RKRRRLV UniProtKB: snRNA-activating protein complex subunit 4

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Macromolecule #4: DNA-directed RNA polymerase III subunit RPC1

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC1 / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO / EC number: DNA-directed RNA polymerase
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 155.860125 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MVKEQFRETD VAKKISHICF GMKSPEEMRQ QAHIQVVSKN LYSQDNQHAP LLYGVLDHRM GTSEKDRPCE TCGKNLADCL GHYGYIDLE LPCFHVGYFR AVIGILQMIC KTCCHIMLSQ EEKKQFLDYL KRPGLTYLQK RGLKKKISDK CRKKNICHHC G AFNGTVKK ...String: MVKEQFRETD VAKKISHICF GMKSPEEMRQ QAHIQVVSKN LYSQDNQHAP LLYGVLDHRM GTSEKDRPCE TCGKNLADCL GHYGYIDLE LPCFHVGYFR AVIGILQMIC KTCCHIMLSQ EEKKQFLDYL KRPGLTYLQK RGLKKKISDK CRKKNICHHC G AFNGTVKK CGLLKIIHEK YKTNKKVVDP IVSNFLQSFE TAIEHNKEVE PLLGRAQENL NPLVVLNLFK RIPAEDVPLL LM NPEAGKP SDLILTRLLV PPLCIRPSVV SDLKSGTNED DLTMKLTEII FLNDVIKKHR ISGAKTQMIM EDWDFLQLQC ALY INSELS GIPLNMAPKK WTRGFVQRLK GKQGRFRGNL SGKRVDFSGR TVISPDPNLR IDEVAVPVHV AKILTFPEKV NKAN INFLR KLVQNGPEVH PGANFIQQRH TQMKRFLKYG NREKMAQELK YGDIVERHLI DGDVVLFNRQ PSLHKLSIMA HLARV KPHR TFRFNECVCT PYNADFDGDE MNLHLPQTEE AKAEALVLMG TKANLVTPRN GEPLIAAIQD FLTGAYLLTL KDTFFD RAK ACQIIASILV GKDEKIKVRL PPPTILKPVT LWTGKQIFSV ILRPSDDNPV RANLRTKGKQ YCGKGEDLCA NDSYVTI QN SELMSGSMDK GTLGSGSKNN IFYILLRDWG QNEAADAMSR LARLAPVYLS NRGFSIGIGD VTPGQGLLKA KYELLNAG Y KKCDEYIEAL NTGKLQQQPG CTAEETLEAL ILKELSVIRD HAGSACLREL DKSNSPLTMA LCGSKGSFIN ISQMIACVG QQAISGSRVP DGFENRSLPH FEKHSKLPAA KGFVANSFYS GLTPTEFFFH TMAGREGLVD TAVKTAETGY MQRRLVKSLE DLCSQYDLT VRSSTGDIIQ FIYGGDGLDP AAMEGKDEPL EFKRVLDNIK AVFPCPSEPA LSKNELILTT ESIMKKSEFL C CQDSFLQE IKKFIKGVSE KIKKTRDKYG INDNGTTEPR VLYQLDRITP TQVEKFLETC RDKYMRAQME PGSAVGALCA QS IGEPGTQ MTLKTFHFAG VASMNITLGV PRIKEIINAS KAISTPIITA QLDKDDDADY ARLVKGRIEK TLLGEISEYI EEV FLPDDC FILVKLSLER IRLLRLEVNA ETVRYSICTS KLRVKPGDVA VHGEAVVCVT PRENSKSSMY YVLQFLKEDL PKVV VQGIP EVSRAVIHID EQSGKEKYKL LVEGDNLRAV MATHGVKGTR TTSNNTYEVE KTLGIEAART TIINEIQYTM VNHGM SIDR RHVMLLSDLM TYKGEVLGIT RFGLAKMKES VLMLASFEKT ADHLFDAAYF GQKDSVCGVS ECIIMGIPMN IGTGLF KLL HKADRDPNPP KRPLIFDTNE FHIPLVT UniProtKB: DNA-directed RNA polymerase III subunit RPC1

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Macromolecule #5: DNA-directed RNA polymerase III subunit RPC2

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC2 / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO / EC number: DNA-directed RNA polymerase
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 127.953891 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MDVLAEEFGN LTPEQLAAPI PTVEEKWRLL PAFLKVKGLV KQHIDSFNYF INVEIKKIMK ANEKVTSDAD PMWYLKYLNI YVGLPDVEE SFNVTRPVSP HECRLRDMTY SAPITVDIEY TRGSQRIIRN ALPIGRMPIM LRSSNCVLTG KTPAEFAKLN E CPLDPGGY ...String: MDVLAEEFGN LTPEQLAAPI PTVEEKWRLL PAFLKVKGLV KQHIDSFNYF INVEIKKIMK ANEKVTSDAD PMWYLKYLNI YVGLPDVEE SFNVTRPVSP HECRLRDMTY SAPITVDIEY TRGSQRIIRN ALPIGRMPIM LRSSNCVLTG KTPAEFAKLN E CPLDPGGY FIVKGVEKVI LIQEQLSKNR IIVEADRKGA VGASVTSSTH EKKSRTNMAV KQGRFYLRHN TLSEDIPIVI IF KAMGVES DQEIVQMIGT EEHVMAAFGP SLEECQKAQI FTQMQALKYI GNKVRRQRMW GGGPKKTKIE EARELLASTI LTH VPVKEF NFRAKCIYTA VMVRRVILAQ GDNKVDDRDY YGNKRLELAG QLLSLLFEDL FKKFNSEMKK IADQVIPKQR AAQF DVVKH MRQDQITNGM VNAISTGNWS LKRFKMDRQG VTQVLSRLSY ISALGMMTRI SSQFEKTRKV SGPRSLQPSQ WGMLC PSDT PEGEACGLVK NLALMTHITT DMEDGPIVKL ASNLGVEDVN LLCGEELSYP NVFLVFLNGN ILGVIRDHKK LVNTFR LMR RAGYINEFVS ISTNLTDRCV YISSDGGRLC RPYIIVKKQK PAVTNKHMEE LAQGYRNFED FLHESLVEYL DVNEEND CN IALYEHTINK DTTHLEIEPF TLLGVCAGLI PYPHHNQSPR NTYQCAMGKQ AMGTIGYNQR NRIDTLMYLL AYPQKPMV K TKTIELIEFE KLPAGQNATV AVMSYSGYDI EDALVLNKAS LDRGFGRCLV YKNAKCTLKR YTNQTFDKVM GPMLDAATR KPIWRHEILD ADGICSPGEK VENKQVLVNK SMPTVTQIPL EGSNVPQQPQ YKDVPITYKG ATDSYIEKVM ISSNAEDAFL IKMLLRQTR RPEIGDKFSS RHGQKGVCGL IVPQEDMPFC DSGICPDIIM NPHGFPSRMT VGKLIELLAG KAGVLDGRFH Y GTAFGGSK VKDVCEDLVR HGYNYLGKDY VTSGITGEPL EAYIYFGPVY YQKLKHMVLD KMHARARGPR AVLTRQPTEG RS RDGGLRL GEMERDCLIG YGASMLLLER LMISSDAFEV DVCGQCGLLG YSGWCHYCKS SCHVSSLRIP YACKLLFQEL QSM NIIPRL KLSKYNE UniProtKB: DNA-directed RNA polymerase III subunit RPC2

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Macromolecule #6: DNA-directed RNA polymerases I and III subunit RPAC1

Macromolecule	Name: DNA-directed RNA polymerases I and III subunit RPAC1 / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 39.301672 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS LEFDMVGIDA AIANAFRRIL LAEVPTMAV EKVLVYNNTS IVQDEILAHR LGLIPIHADP RLFEYRNQGD EEGTEIDTLQ FRLQVRCTRN PHAAKDSSDP N ELYVNHKV ...String: MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS LEFDMVGIDA AIANAFRRIL LAEVPTMAV EKVLVYNNTS IVQDEILAHR LGLIPIHADP RLFEYRNQGD EEGTEIDTLQ FRLQVRCTRN PHAAKDSSDP N ELYVNHKV YTRHMTWIPL GNQADLFPEG TIRPVHDDIL IAQLRPGQEI DLLMHCVKGI GKDHAKFSPV ATASYRLLPD IT LLEPVEG EAAEELSRCF SPGVIEVQEV QGKKVARVAN PRLDTFSREI FRNEKLKKVV RLARVRDHYI FSVESTGVLP PDV LVSEAI KVLMGKCRRF LDELDAVQMD UniProtKB: DNA-directed RNA polymerases I and III subunit RPAC1

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Macromolecule #7: DNA-directed RNA polymerase III subunit RPC9

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC9 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 16.89399 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH QSPEIVREFL TALKSHKLTK AEKLQLLNH RPVTAVEIQL MVEESEERLT EEQIEALLHT VTSILPAEPE AEQKKNTNSN VAMDEEDPA UniProtKB: DNA-directed RNA polymerase III subunit RPC9

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Macromolecule #8: DNA-directed RNA polymerases I, II, and III subunit RPABC1

Macromolecule	Name: DNA-directed RNA polymerases I, II, and III subunit RPABC1 type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 24.584223 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MDDEEETYRL WKIRKTIMQL CHDRGYLVTQ DELDQTLEEF KAQSGDKPSE GRPRRTDLTV LVAHNDDPTD QMFVFFPEEP KVGIKTIKV YCQRMQEENI TRALIVVQQG MTPSAKQSLV DMAPKYILEQ FLQQELLINI TEHELVPEHV VMTKEEVTEL L ARYKLREN ...String: MDDEEETYRL WKIRKTIMQL CHDRGYLVTQ DELDQTLEEF KAQSGDKPSE GRPRRTDLTV LVAHNDDPTD QMFVFFPEEP KVGIKTIKV YCQRMQEENI TRALIVVQQG MTPSAKQSLV DMAPKYILEQ FLQQELLINI TEHELVPEHV VMTKEEVTEL L ARYKLREN QLPRIQAGDP VARYFGIKRG QVVKIIRPSE TAGRYITYRL VQ UniProtKB: DNA-directed RNA polymerases I, II, and III subunit RPABC1

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Macromolecule #9: DNA-directed RNA polymerases I, II, and III subunit RPABC2

Macromolecule	Name: DNA-directed RNA polymerases I, II, and III subunit RPABC2 type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 14.491026 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MSDNEDNFDG DDFDDVEEDE GLDDLENAEE EGQENVEILP SGERPQANQK RITTPYMTKY ERARVLGTRA LQIAMCAPVM VELEGETDP LLIAMKELKA RKIPIIIRRY LPDGSYEDWG VDELIITD UniProtKB: DNA-directed RNA polymerases I, II, and III subunit RPABC2

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Macromolecule #10: DNA-directed RNA polymerase III subunit RPC8

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC8 / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 22.938846 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MFVLVEMVDT VRIPPWQFER KLNDSIAEEL NKKLANKVVY NVGLCICLFD ITKLEDAYVF PGDGASHTKV HFRCVVFHPF LDEILIGKI KGCSPEGVHV SLGFFDDILI PPESLQQPAK FDEAEQVWVW EYETEEGAHD LYMDTGEEIR FRVVDESFVD T SPTGPSSA ...String: MFVLVEMVDT VRIPPWQFER KLNDSIAEEL NKKLANKVVY NVGLCICLFD ITKLEDAYVF PGDGASHTKV HFRCVVFHPF LDEILIGKI KGCSPEGVHV SLGFFDDILI PPESLQQPAK FDEAEQVWVW EYETEEGAHD LYMDTGEEIR FRVVDESFVD T SPTGPSSA DATTSSEELP KKEAPYTLVG SISEPGLGLL SWWTSN UniProtKB: DNA-directed RNA polymerase III subunit RPC8

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Macromolecule #11: DNA-directed RNA polymerases I, II, and III subunit RPABC3

Macromolecule	Name: DNA-directed RNA polymerases I, II, and III subunit RPABC3 type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 17.162273 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MAGILFEDIF DVKDIDPEGK KFDRVSRLHC ESESFKMDLI LDVNIQIYPV DLGDKFRLVI ASTLYEDGTL DDGEYNPTDD RPSRADQFE YVMYGKVYRI EGDETSTEAA TRLSAYVSYG GLLMRLQGDA NNLHGFEVDS RVYLLMKKLA F UniProtKB: DNA-directed RNA polymerases I, II, and III subunit RPABC3

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Macromolecule #12: DNA-directed RNA polymerase III subunit RPC10

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC10 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 12.338104 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MLLFCPGCGN GLIVEEGQRC HRFACNTCPY VHNITRKVTN RKYPKLKEVD DVLGGAAAWE NVDSTAESCP KCEHPRAYFM QLQTRSADE PMTTFYKCCN AQCGHRWRD UniProtKB: DNA-directed RNA polymerase III subunit RPC10

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Macromolecule #13: DNA-directed RNA polymerases I, II, and III subunit RPABC5

Macromolecule	Name: DNA-directed RNA polymerases I, II, and III subunit RPABC5 type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 7.655123 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL AHVDLIEKLL NYAPLEK UniProtKB: DNA-directed RNA polymerases I, II, and III subunit RPABC5

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Macromolecule #14: DNA-directed RNA polymerases I and III subunit RPAC2

Macromolecule	Name: DNA-directed RNA polymerases I and III subunit RPAC2 / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 15.259222 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MEEDQELERK ISGLKTSMAE GERKTALEMV QAAGTDRHCV TFVLHEEDHT LGNSLRYMIM KNPEVEFCGY TTTHPSESKI NLRIQTRGT LPAVEPFQRG LNELMNVCQH VLDKFEASIK DYKDQKASRN ESTF UniProtKB: DNA-directed RNA polymerases I and III subunit RPAC2

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Macromolecule #15: DNA-directed RNA polymerases I, II, and III subunit RPABC4

Macromolecule	Name: DNA-directed RNA polymerases I, II, and III subunit RPABC4 type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 7.018244 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MDTQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK RLVVFDAR UniProtKB: DNA-directed RNA polymerases I, II, and III subunit RPABC4

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Macromolecule #16: DNA-directed RNA polymerase III subunit RPC5

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC5 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 80.004031 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADET STYSSKLMDK QTFCSSQTTS NTSRYAAALY RQGELHLTPL HGILQLRPSF SYLDKADAKH REREAANEAG D SSQDEAED ...String: MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADET STYSSKLMDK QTFCSSQTTS NTSRYAAALY RQGELHLTPL HGILQLRPSF SYLDKADAKH REREAANEAG D SSQDEAED DVKQITVRFS RPESEQARQR RVQSYEFLQK KHAEEPWVHL HYYGLRDSRS EHERQYLLCP GSSGVENTEL VK SPSEYLM MLMPPSQEEE KDKPVAPSNV LSMAQLRTLP LADQIKILMK NVKVMPFANL MSLLGPSIDS VAVLRGIQKV AML VQGNWV VKSDILYPKD SSSPHSGVPA EVLCRGRDFV MWKFTQSRWV VRKEVATVTK LCAEDVKDFL EHMAVVRINK GWEF ILPYD GEFIKKHPDV VQRQHMLWTG IQAKLEKVYN LVKETMPKKP DAQSGPAGLV CGDQRIQVAK TKAQQNHALL ERELQ RRKE QLRVPAVPPG VRIKEEPVSE EGEEDEEQEA EEEPMDTSPS GLHSKLANGL PLGRAAGTDS FNGHPPQGCA STPVAR ELK AFVEATFQRQ FVLTLSELKR LFNLHLASLP PGHTLFSGIS DRMLQDTVLA AGCKQILVPF PPQTAASPDE QKVFALW ES GDMSDQHRQV LLEIFSKNYR VRRNMIQSRL TQECGEDLSK QEVDKVLKDC CVSYGGMWYL KGTVQS UniProtKB: DNA-directed RNA polymerase III subunit RPC5

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Macromolecule #17: DNA-directed RNA polymerase III subunit RPC4

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC4 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 35.195559 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MSEGNAAGEP STPGGPRPLL TGARGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP NIISRKIKEE PKEEVTVKKE KRERDRDRQ REGHGRGRGR PEVIQSHSIF EQGPAEMMKK KGNWDKTVDV SDMGPSHIIN IKKEKRETDE ETKQILRMLE K TPGLPKDV ...String: MSEGNAAGEP STPGGPRPLL TGARGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP NIISRKIKEE PKEEVTVKKE KRERDRDRQ REGHGRGRGR PEVIQSHSIF EQGPAEMMKK KGNWDKTVDV SDMGPSHIIN IKKEKRETDE ETKQILRMLE K TPGLPKDV SVAELLRELS LTKEEELLFL QLPDTLPGQP PTQDIKPIKT EVQGEDGQVV LIKQEKDREA KLAENACTLA DL TEGQVGK LLIRKSGRVQ LLLGKVTLDV TMGTACSFLQ ELVSVGLGDS RTGEMTVLGH VKHKLVCSPD FESLLDHKHR

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Macromolecule #18: DNA-directed RNA polymerase III subunit RPC3

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC3 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 60.692555 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYP RYIYTTKTLY SDTGELIVEE LLLNGKLTMS AVVKKVADRL TETMEDGKTM DYAEVSNTFV RLADTHFVQR C PSVPTTEN ...String: MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYP RYIYTTKTLY SDTGELIVEE LLLNGKLTMS AVVKKVADRL TETMEDGKTM DYAEVSNTFV RLADTHFVQR C PSVPTTEN SDPGPPPPAP TLVINEKDMY LVPKLSLIGK GKRRRSSDED AAGEPKAKRP KYTTDNKEPI PDDGIYWQAN LD RFHQHFR DQAIVSAVAN RMDQTSSEIV RTMLRMSEIT TSSSAPFTQP LSSNEIFRSL PVGYNISKQV LDQYLTLLAD DPL EFVGKS GDSGGGMYVI NLHKALASLA TATLESVVQE RFGSRCARIF RLVLQKKHIE QKQVEDFAMI PAKEAKDMLY KMLS ENFMS LQEIPKTPDH APSRTFYLYT VNILSAARML LHRCYKSIAN LIERRQFETK ENKRLLEKSQ RVEAIIASMQ ATGAE EAQL QEIEEMITAP ERQQLETLKR NVNKLDASEI QVDETIFLLE SYIECTMKRQ UniProtKB: DNA-directed RNA polymerase III subunit RPC3

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Macromolecule #19: DNA-directed RNA polymerase III subunit RPC6

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC6 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 35.726914 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MAEVKVKVQP PDADPVEIEN RIIELCHQFP HGITDQVIQN EMPHIEAQQR AVAINRLLSM GQLDLLRSNT GLLYRIKDSQ NAGKMKGSD NQEKLVYQII EDAGNKGIWS RDIRYKSNLP LTEINKILKN LESKKLIKAV KSVAASKKKV YMLYNLQPDR S VTGGAWYS ...String: MAEVKVKVQP PDADPVEIEN RIIELCHQFP HGITDQVIQN EMPHIEAQQR AVAINRLLSM GQLDLLRSNT GLLYRIKDSQ NAGKMKGSD NQEKLVYQII EDAGNKGIWS RDIRYKSNLP LTEINKILKN LESKKLIKAV KSVAASKKKV YMLYNLQPDR S VTGGAWYS DQDFESEFVE VLNQQCFKFL QSKAETARES KQNPMIQRNS SFASSHEVWK YICELGISKV ELSMEDIETI LN TLIYDGK VEMTIIAAKE GTVGSVDGHM KLYRAVNPII PPTGLVRAPC GLCPVFDDCH EGGEISPSNC IYMTEWLEF UniProtKB: DNA-directed RNA polymerase III subunit RPC6

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Macromolecule #20: DNA-directed RNA polymerase III subunit RPC7

Macromolecule	Name: DNA-directed RNA polymerase III subunit RPC7 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 25.95351 KDa
Recombinant expression	Organism: Homo sapiens (human)
Sequence	String: MAGNKGRGRA AYTFNIEAVG FSKGEKLPDV VLKPPPLFPD TDYKPVPLKT GEGEEYMLAL KQELRETMKR MPYFIETPEE RQDIERYSK RYMKVYKEEW IPDWRRLPRE MMPRNKCKKA GPKPKKAKDA GKGTPLTNTE DVLKKMEELE KRGDGEKSDE E NEEKEGSK ...String: MAGNKGRGRA AYTFNIEAVG FSKGEKLPDV VLKPPPLFPD TDYKPVPLKT GEGEEYMLAL KQELRETMKR MPYFIETPEE RQDIERYSK RYMKVYKEEW IPDWRRLPRE MMPRNKCKKA GPKPKKAKDA GKGTPLTNTE DVLKKMEELE KRGDGEKSDE E NEEKEGSK EKSKEGDDDD DDDAAEQEEY DEEEQEEEND YINSYFEDGD DFGADSDDNM DEATY UniProtKB: DNA-directed RNA polymerase III subunit RPC7

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Macromolecule #21: TATA-box-binding protein

Macromolecule	Name: TATA-box-binding protein / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 37.729938 KDa
Recombinant expression	Organism: Escherichia coli (E. coli)
Sequence	String: MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQ QQQQQQAVAA AAVQQSTSQQ ATQGTSGQAP QLFHSQTLTT APLPGTTPLY PSPMTPMTPI TPATPASESS G IVPQLQNI ...String: MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQ QQQQQQAVAA AAVQQSTSQQ ATQGTSGQAP QLFHSQTLTT APLPGTTPLY PSPMTPMTPI TPATPASESS G IVPQLQNI VSTVNLGCKL DLKTIALRAR NAEYNPKRFA AVIMRIREPR TTALIFSSGK MVCTGAKSEE QSRLAARKYA RV VQKLGFP AKFLDFKIQN MVGSCDVKFP IRLEGLVLTH QQFSSYEPEL FPGLIYRMIK PRIVLLIFVS GKVVLTGAKV RAE IYEAFE NIYPILKGFR KTT UniProtKB: TATA-box-binding protein

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Macromolecule #22: Transcription factor IIIB 50 kDa subunit

Macromolecule	Name: Transcription factor IIIB 50 kDa subunit / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 46.587355 KDa
Recombinant expression	Organism: Escherichia coli (E. coli)
Sequence	String: MPGRGRCPDC GSTELVEDSH YSQSQLVCSD CGCVVTEGVL TTTFSDEGNL REVTYSRSTG ENEQVSRSQQ RGLRRVRDLC RVLQLPPTF EDTAVAYYQQ AYRHSGIRAA RLQKKEVLVG CCVLITCRQH NWPLTMGAIC TLLYADLDVF SSTYMQIVKL L GLDVPSLC ...String: MPGRGRCPDC GSTELVEDSH YSQSQLVCSD CGCVVTEGVL TTTFSDEGNL REVTYSRSTG ENEQVSRSQQ RGLRRVRDLC RVLQLPPTF EDTAVAYYQQ AYRHSGIRAA RLQKKEVLVG CCVLITCRQH NWPLTMGAIC TLLYADLDVF SSTYMQIVKL L GLDVPSLC LAELVKTYCS SFKLFQASPS VPAKYVEDKE KMLSRTMQLV ELANETWLVT GRHPLPVITA ATFLAWQSLQ PA DRLSCSL ARFCKLANVD LPYPASSRLQ ELLAVLLRMA EQLAWLRVLR LDKRSVVKHI GDLLQHRQSL VRSAFRDGTA EVE TREKEP PGWGQGQGEG EVGNNSLGLP QGKRPASPAL LLPPCMLKSP KRICPVPPVS TVTGDENISD SEIEQYLRTP QEVR DFQRA QAARQAATSV PNPP UniProtKB: Transcription factor IIIB 50 kDa subunit

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Macromolecule #23: Transcription factor TFIIIB component B'' homolog

Macromolecule	Name: Transcription factor TFIIIB component B'' homolog / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 294.301375 KDa
Recombinant expression	Organism: Escherichia coli (E. coli)
Sequence	String: MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG AEPQEKAPRS STEKTGGDND VEESSRSSS TVSQRRKRIS STSSLVKSSV SVPSESHPLS TINQEAPQPT ATSTKEKQPC SDRYRIYKAQ KLREMLKEEL R KEKKQWKN ...String: MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG AEPQEKAPRS STEKTGGDND VEESSRSSS TVSQRRKRIS STSSLVKSSV SVPSESHPLS TINQEAPQPT ATSTKEKQPC SDRYRIYKAQ KLREMLKEEL R KEKKQWKN KYAINESQRP PDRSKMTMRD FIYYLPDNNP MTSSLEQEKK TEKPSTPVQT REQEGKSTPN AEDNEMEEET DD GPLLVPR VKVAEDGSII LDEESLTVEV LRTKGPCVVE ENDPIFERGS TTTYSSFRKN YYSKPWSNKE TDMFFLAISM VGT DFSMIG QLFPHRARIE IKNKFKREEK TNGWRIDKAF QEKRPFDFDF FAHLLQKVLA EEEKRKQKSV KNHSLKEKKS TKPR KNVKV KKVACEGVNN DPDESMSSRI SDTERSQKDA QTVEEESLTL SREDAEQVAL EVDLNQKKRR RKKQDGANEL GVNNL LENA TVQAGPSKGE KHKNKCQAIR PELKEGECSK EQMLSCTQNI DGIVGFASTE KVEKRTDPIL SLSNQQDATS VATESS ESS TSDLPSFEVG IRALCEVNNA EGSCIEERNV DLKNNSLEID QTENVKPMLR GRFQRPKPNL SRAGKKSVLS QGKTESE SK NSHSKTSVEK NHVEKDKMNT LDILRMETTE RENPEAETVS VLGEKNCLQE GSQLKALRPV QVRGRLQKPK PNAGKAAE R KEILISQEEI GANVEKNENE SCADRDTPQH MEDQSRKDFE EEDVILQPEK NDSFQNVQPD EPKVLNECLS VQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKIL DVIDDTIEME TGLKAMGREI CLREKTPEVI DATEEIDKDL EEAGRREISP QKNGPEEVKP LGEVETDLKA T GNESSPRE KTPEVTDATE EIDKNLEETG RRKISPRENG PEEVKPVDEM ETDLNATGRE SSPREKTPEV IDATEEIDLE ET EREVSPQ ENGLEEVKPL GEMETDLKAT GRDSFPRGKT PEVIDAIEEI EIDLEETERE ISPQENGLEE VKPLGEMQTD LKA TGREIS PREKTPEVID ATEEIDKDLE ETGRREISPE ENGPEEVKPV DEMETDLKTT GREGSSREKT REVIDAAEVI ETDL EETER EISPQENGPE EVKPVGKMET DLKEIREEIS QREKVLAEFS AIREKEIDLK ETGKRDIPIM EKVSGKMAVV EEMEA DLKE TGKENFRERG SEEICVTEEK VAELKQTGKT DISPRENELE ETSTSRQTDT HLMQSGSNDF SAVPSLDIQN ISSEVL SMM HTPVEEKRNS EKEVSSHFSH FKISSQTHES DKTEVQGIQS PDVPEQFSDI NLSKSLPQEQ KPLEIKPAPF VRSRFKR PK PNLARAALKR ETTESEKYIY EKKSETKKME TIVMQENNEQ TDTLPSQHDE ASLMISREKD TLGHRNEEAV ILPCTQTE R NLSPSNSCEP KEESQSAPVQ KNDSVVSVGT NNVNTFQQEM KESVIQTARQ VRGRLQRPRP NIRKTGQRQI VDKGEAKGI IKEGRTILPK DETEKKVLTV SNSQIETEIE VPSSAVPEHR MYENQSQVVL VENLHVNKTN ETIRHENKPY VPSSAQMTRR KFQKAKPNL GRAHSKKEEP VLEKVTTDQS KEGKPEDHLL QKGASNTQLL LKEKAELLTS LEVSARKDCV GSKESALAKI D AELEEVGP SRRVGEETVG DNSPSSVVEE QYLNKLTSCP QPLNETSYSK IALDGKTTIS STSEYERNRG ERRSHKKFKP NV TRGRGSK RVRGKTSKKE PRASKAMLVT LRASQEEDDD ADDFESDYEE ESYHLAPEEV NKAPVFVPVG LRSPEPVSAQ IEE TMEELE ITVNVPDVGC IAVVEHELPN TDVTTEEMKQ EENLSVPFEM TTSEHIQDEP GTNDGSTEAA ITLLTMGDLV LQSE ISSEQ GDVGVCIIPH VHSKDKSHIP SSLDNVNHKI VHECQELSSP VITTSPASFE ENKIVLEEQS SREEISLMEK VKENA TPTR NTISKVTSNL RIRSRLAKPK PNLEKTLGTN RLDDYQEVSS LCVTKGAEME TQRETEKNAS KATELENKNL GPVTTA ENK DQSKLACVHG IKGTSISSEV NLTERNENQE ESSQEVHMLS VAPVASSETG PCTLGLDRGL GENSVEEPQI KDSKGDS VL TLPVPEYTPT SIPEVQQENI INPQDLTVNL VANVPQDGED EQAFILTLVE IPANAVEEFT DATAQFMPNP LLPAPILV K SVNTEERGDM SICLPATSVG QDAMGLSISG RDNSKKPPDN LDLVSRKRFQ CRLDKNDHIP PAKKRSLTLR DDCQEYTTE VHSKELTNVF EETGESHKGQ DIFLTSGSTL TTPEPQRQQV EAAFQSRGSR SPDACMDKNV PQLPQDEMIV SDKEERTDAA PKSQQMDSR TSSSKASLSR PGRRPLGFLS LICSKNSLES DEPMQVHSKK RLKPLIPGLR KKLKRSNPFN ESQEKNRESS D LLPSPSVI TTQSENISSS ATQVSCDQPL LKEGYKSAQK RAPQGEATTV SEYFFNDIFI EVDETE UniProtKB: Transcription factor TFIIIB component B'' homolog

+
Macromolecule #24: DNA (82-MER)

Macromolecule	Name: DNA (82-MER) / type: dna / ID: 24 / Number of copies: 1 / Classification: DNA
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 143.5125 KDa
Sequence	String: (DA)(DA)(DG)(DG)(DT)(DC)(DG)(DG)(DG)(DC) (DA)(DG)(DG)(DA)(DA)(DG)(DA)(DG)(DG)(DG) (DC)(DC)(DT)(DA)(DT)(DT)(DT)(DC)(DC) (DC)(DA)(DT)(DG)(DA)(DT)(DT)(DC)(DC)(DT) (DT) (DC)(DA)(DT)(DA)(DT)(DT) ...String: (DA)(DA)(DG)(DG)(DT)(DC)(DG)(DG)(DG)(DC) (DA)(DG)(DG)(DA)(DA)(DG)(DA)(DG)(DG)(DG) (DC)(DC)(DT)(DA)(DT)(DT)(DT)(DC)(DC) (DC)(DA)(DT)(DG)(DA)(DT)(DT)(DC)(DC)(DT) (DT) (DC)(DA)(DT)(DA)(DT)(DT)(DT)(DG) (DC)(DA)(DT)(DA)(DT)(DA)(DC)(DG)(DA)(DT) (DA)(DC) (DA)(DA)(DG)(DG)(DC)(DT)(DG) (DT)(DT)(DA)(DG)(DA)(DG)(DA)(DG)(DA)(DT) (DA)(DA)(DT) (DT)(DA)(DG)(DA)(DA)(DT) (DT)(DA)(DA)(DT)(DT)(DT)(DG)(DA)(DC)(DT) (DG)(DT)(DA)(DA) (DA)(DC)(DA)(DC)(DA) (DA)(DA)(DG)(DA)(DT)(DA)(DT)(DT)(DA)(DG) (DT)(DA)(DC)(DA)(DA) (DA)(DA)(DT)(DA) (DC)(DG)(DT)(DG)(DA)(DC)(DG)(DT)(DA)(DG) (DA)(DA)(DA)(DG)(DT)(DA) (DA)(DT)(DA) (DA)(DT)(DT)(DT)(DC)(DT)(DT)(DG)(DG)(DG) (DT)(DA)(DG)(DT)(DT)(DT)(DG) (DC)(DA) (DG)(DT)(DT)(DT)(DT)(DT)(DA)(DA)(DA)(DA) (DT)(DT)(DA)(DT)(DG)(DT)(DT)(DT) (DT) (DA)(DA)(DA)(DA)(DT)(DG)(DG)(DA)(DC)(DT) (DA)(DT)(DC)(DA)(DT)(DA)(DT)(DG)(DC) (DT)(DT)(DA)(DC)(DC)(DG)(DT)(DA)(DA)(DC) (DT)(DT)(DG)(DA)(DA)(DA)(DG)(DT)(DA)(DT) (DT)(DT)(DC)(DG)(DA)(DT)(DT)(DT)(DC) (DT)(DT)(DG)(DG)(DC)(DT)(DT)(DT)(DA)(DT) (DA) (DT)(DA)(DT)(DC)(DT)(DT)(DG)(DT) (DG)(DG)(DA)(DA)(DA)(DG)(DG)(DA)(DC)(DG) (DA)(DA) (DA)(DC)(DA)(DC)(DC)(DG)(DT) (DG)(DC)(DT)(DC)(DG)(DC)(DT)(DT)(DC)(DG) (DG)(DC)(DA) (DG)(DC)(DA)(DC)(DA)(DT) (DA)(DT)(DA)(DC)(DT)(DA)(DA)(DA)(DA)(DT) (DT)(DG)(DG)(DA) (DA)(DC)(DG)(DA)(DT) (DA)(DC)(DA)(DG)(DA)(DG)(DA)(DA)(DG)(DA) (DT)(DT)(DA)(DG)(DC) (DA)(DT)(DG)(DG) (DC)(DC)(DC)(DC)(DT)(DG)(DC)(DG)(DC)(DA) (DA)(DG)(DG)(DA)(DT)(DG) (DA)(DC)(DA) (DC)(DG)(DC)(DA)(DA)(DA)(DT)(DT)(DC)(DG) (DT)(DG)(DA)(DA)(DG)(DC)(DG) (DT)(DT) (DC)(DC)(DA)(DT)(DA)(DT)(DT)(DT)(DT)(DT) (DA)(DC)(DA)(DT)(DC)(DA)(DG)(DG) (DT) (DT)(DG)(DT)(DT)(DT)(DT)(DT)(DC)(DT)(DG) (DT)(DT)(DT)(DT)(DT)(DA)(DC)(DA)(DT) (DC)(DA)(DG)(DG)(DT)(DT)(DG)(DT)(DT)(DT) (DT)(DT)(DC)(DT)(DG)(DT)(DT)(DT)(DG)(DG) (DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT) (DT)(DA)(DC)(DA)(DC)(DC)(DA)(DC)(DG)(DT) (DT) (DT)(DA)(DT)(DA)(DC)(DG)(DC)(DC) (DG)(DG)(DT)(DG)(DC)(DA)(DC)(DG)(DG)(DT) (DT)(DT) (DA)(DC)(DC)(DA) GENBANK: GENBANK: X07425.1

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Macromolecule #25: DNA (82-MER)

Macromolecule	Name: DNA (82-MER) / type: dna / ID: 25 / Number of copies: 1 / Classification: DNA
Source (natural)	Organism: Homo sapiens (human)
Molecular weight	Theoretical: 143.039469 KDa
Sequence	String: (DT)(DG)(DG)(DT)(DA)(DA)(DA)(DC)(DC)(DG) (DT)(DG)(DC)(DA)(DC)(DC)(DG)(DG)(DC)(DG) (DT)(DA)(DT)(DA)(DA)(DA)(DC)(DG)(DT) (DG)(DG)(DT)(DG)(DT)(DA)(DA)(DA)(DA)(DA) (DA) (DA)(DA)(DA)(DA)(DC)(DC) ...String: (DT)(DG)(DG)(DT)(DA)(DA)(DA)(DC)(DC)(DG) (DT)(DG)(DC)(DA)(DC)(DC)(DG)(DG)(DC)(DG) (DT)(DA)(DT)(DA)(DA)(DA)(DC)(DG)(DT) (DG)(DG)(DT)(DG)(DT)(DA)(DA)(DA)(DA)(DA) (DA) (DA)(DA)(DA)(DA)(DC)(DC)(DA)(DA) (DA)(DC)(DA)(DG)(DA)(DA)(DA)(DA)(DA)(DC) (DA)(DA) (DC)(DC)(DT)(DG)(DA)(DT)(DG) (DT)(DA)(DA)(DA)(DA)(DA)(DC)(DA)(DG)(DA) (DA)(DA)(DA) (DA)(DC)(DA)(DA)(DC)(DC) (DT)(DG)(DA)(DT)(DG)(DT)(DA)(DA)(DA)(DA) (DA)(DT)(DA)(DT) (DG)(DG)(DA)(DA)(DC) (DG)(DC)(DT)(DT)(DC)(DA)(DC)(DG)(DA)(DA) (DT)(DT)(DT)(DG)(DC) (DG)(DT)(DG)(DT) (DC)(DA)(DT)(DC)(DC)(DT)(DT)(DG)(DC)(DG) (DC)(DA)(DG)(DG)(DG)(DG) (DC)(DC)(DA) (DT)(DG)(DC)(DT)(DA)(DA)(DT)(DC)(DT)(DT) (DC)(DT)(DC)(DT)(DG)(DT)(DA) (DT)(DC) (DG)(DT)(DT)(DC)(DC)(DA)(DA)(DT)(DT)(DT) (DT)(DA)(DG)(DT)(DA)(DT)(DA)(DT) (DG) (DT)(DG)(DC)(DT)(DG)(DC)(DC)(DG)(DA)(DA) (DG)(DC)(DG)(DA)(DG)(DC)(DA)(DC)(DG) (DG)(DT)(DG)(DT)(DT)(DT)(DC)(DG)(DT)(DC) (DC)(DT)(DT)(DT)(DC)(DC)(DA)(DC)(DA)(DA) (DG)(DA)(DT)(DA)(DT)(DA)(DT)(DA)(DA) (DA)(DG)(DC)(DC)(DA)(DA)(DG)(DA)(DA)(DA) (DT) (DC)(DG)(DA)(DA)(DA)(DT)(DA)(DC) (DT)(DT)(DT)(DC)(DA)(DA)(DG)(DT)(DT)(DA) (DC)(DG) (DG)(DT)(DA)(DA)(DG)(DC)(DA) (DT)(DA)(DT)(DG)(DA)(DT)(DA)(DG)(DT)(DC) (DC)(DA)(DT) (DT)(DT)(DT)(DA)(DA)(DA) (DA)(DC)(DA)(DT)(DA)(DA)(DT)(DT)(DT)(DT) (DA)(DA)(DA)(DA) (DA)(DC)(DT)(DG)(DC) (DA)(DA)(DA)(DC)(DT)(DA)(DC)(DC)(DC)(DA) (DA)(DG)(DA)(DA)(DA) (DT)(DT)(DA)(DT) (DT)(DA)(DC)(DT)(DT)(DT)(DC)(DT)(DA)(DC) (DG)(DT)(DC)(DA)(DC)(DG) (DT)(DA)(DT) (DT)(DT)(DT)(DG)(DT)(DA)(DC)(DT)(DA)(DA) (DT)(DA)(DT)(DC)(DT)(DT)(DT) (DG)(DT) (DG)(DT)(DT)(DT)(DA)(DC)(DA)(DG)(DT)(DC) (DA)(DA)(DA)(DT)(DT)(DA)(DA)(DT) (DT) (DC)(DT)(DA)(DA)(DT)(DT)(DA)(DT)(DC)(DT) (DC)(DT)(DC)(DT)(DA)(DA)(DC)(DA)(DG) (DC)(DC)(DT)(DT)(DG)(DT)(DA)(DT)(DC)(DG) (DT)(DA)(DT)(DA)(DT)(DG)(DC)(DA)(DA)(DA) (DT)(DA)(DT)(DG)(DA)(DA)(DG)(DG)(DA) (DA)(DT)(DC)(DA)(DT)(DG)(DG)(DG)(DA)(DA) (DA) (DT)(DA)(DG)(DG)(DC)(DC)(DC)(DT) (DC)(DT)(DT)(DC)(DC)(DT)(DG)(DC)(DC)(DC) (DG)(DA) (DC)(DC)(DT)(DT) GENBANK: GENBANK: X07425.1

+
Macromolecule #26: ZINC ION

Macromolecule	Name: ZINC ION / type: ligand / ID: 26 / Number of copies: 7 / Formula: ZN
Molecular weight	Theoretical: 65.409 Da

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Macromolecule #27: MAGNESIUM ION

Macromolecule	Name: MAGNESIUM ION / type: ligand / ID: 27 / Number of copies: 1 / Formula: MG
Molecular weight	Theoretical: 24.305 Da

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Macromolecule #28: IRON/SULFUR CLUSTER

Macromolecule	Name: IRON/SULFUR CLUSTER / type: ligand / ID: 28 / Number of copies: 1 / Formula: SF4
Molecular weight	Theoretical: 351.64 Da
Chemical component information	ChemComp-FS1: IRON/SULFUR CLUSTER

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Experimental details

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Structure determination

Method	cryo EM
Processing	single particle reconstruction
Aggregation state	particle

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Sample preparation

Buffer	pH: 8
Vitrification	Cryogen name: ETHANE-PROPANE

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Electron microscopy

Microscope	FEI TITAN KRIOS
Image recording	Film or detector model: GATAN K3 (6k x 4k) / Average electron dose: 40.0 e/Å²
Electron beam	Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron optics	Illumination mode: OTHER / Imaging mode: BRIGHT FIELD / Nominal defocus max: 3.0 µm / Nominal defocus min: 1.5 µm
Experimental equipment	Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Startup model	Type of model: OTHER
Final reconstruction	Resolution.type: BY AUTHOR / Resolution: 3.9 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 70361
Initial angle assignment	Type: MAXIMUM LIKELIHOOD
Final angle assignment	Type: MAXIMUM LIKELIHOOD

+
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-Additional map: TFIIIB-SNAPC masked

-Half map: half map1

-Half map: half map2

-Sample components

+Entire : RNA polymerase III pre-initiation complex closed complex 1

+Supramolecule #1: RNA polymerase III pre-initiation complex closed complex 1

+Supramolecule #2: RNA polymerase III pre-initiation complex closed complex 1

+Supramolecule #3: RNA polymerase III pre-initiation complex closed complex 1

+Supramolecule #4: DNA

+Macromolecule #1: snRNA-activating protein complex subunit 1

+Macromolecule #2: snRNA-activating protein complex subunit 3

+Macromolecule #3: snRNA-activating protein complex subunit 4

+Macromolecule #4: DNA-directed RNA polymerase III subunit RPC1

+Macromolecule #5: DNA-directed RNA polymerase III subunit RPC2

+Macromolecule #6: DNA-directed RNA polymerases I and III subunit RPAC1

+Macromolecule #7: DNA-directed RNA polymerase III subunit RPC9

+Macromolecule #8: DNA-directed RNA polymerases I, II, and III subunit RPABC1

+Macromolecule #9: DNA-directed RNA polymerases I, II, and III subunit RPABC2

+Macromolecule #10: DNA-directed RNA polymerase III subunit RPC8

+Macromolecule #11: DNA-directed RNA polymerases I, II, and III subunit RPABC3

+Macromolecule #12: DNA-directed RNA polymerase III subunit RPC10

+Macromolecule #13: DNA-directed RNA polymerases I, II, and III subunit RPABC5

+Macromolecule #14: DNA-directed RNA polymerases I and III subunit RPAC2

+Macromolecule #15: DNA-directed RNA polymerases I, II, and III subunit RPABC4

+Macromolecule #16: DNA-directed RNA polymerase III subunit RPC5

+Macromolecule #17: DNA-directed RNA polymerase III subunit RPC4

+Macromolecule #18: DNA-directed RNA polymerase III subunit RPC3

+Macromolecule #19: DNA-directed RNA polymerase III subunit RPC6

+Macromolecule #20: DNA-directed RNA polymerase III subunit RPC7

+Macromolecule #21: TATA-box-binding protein

+Macromolecule #22: Transcription factor IIIB 50 kDa subunit

+Macromolecule #23: Transcription factor TFIIIB component B'' homolog

+Macromolecule #24: DNA (82-MER)

+Macromolecule #25: DNA (82-MER)

+Macromolecule #26: ZINC ION

+Macromolecule #27: MAGNESIUM ION

+Macromolecule #28: IRON/SULFUR CLUSTER

-Experimental details

-Structure determination

-Sample preparation

-Electron microscopy

-Image processing

+About Yorodumi

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-Feb 9, 2022. New format data for meta-information of EMDB entries

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Downloads & links

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Related structure data

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Links

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Map

-
Supplemental data

-
Additional map: TFIIIB-SNAPC masked

-
Half map: half map1

-
Half map: half map2

-
Sample components

+
Entire : RNA polymerase III pre-initiation complex closed complex 1

+
Supramolecule #1: RNA polymerase III pre-initiation complex closed complex 1

+
Supramolecule #2: RNA polymerase III pre-initiation complex closed complex 1

+
Supramolecule #3: RNA polymerase III pre-initiation complex closed complex 1

+
Supramolecule #4: DNA

+
Macromolecule #1: snRNA-activating protein complex subunit 1

+
Macromolecule #2: snRNA-activating protein complex subunit 3

+
Macromolecule #3: snRNA-activating protein complex subunit 4

+
Macromolecule #4: DNA-directed RNA polymerase III subunit RPC1

+
Macromolecule #5: DNA-directed RNA polymerase III subunit RPC2

+
Macromolecule #6: DNA-directed RNA polymerases I and III subunit RPAC1

+
Macromolecule #7: DNA-directed RNA polymerase III subunit RPC9

+
Macromolecule #8: DNA-directed RNA polymerases I, II, and III subunit RPABC1

+
Macromolecule #9: DNA-directed RNA polymerases I, II, and III subunit RPABC2

+
Macromolecule #10: DNA-directed RNA polymerase III subunit RPC8

+
Macromolecule #11: DNA-directed RNA polymerases I, II, and III subunit RPABC3

+
Macromolecule #12: DNA-directed RNA polymerase III subunit RPC10

+
Macromolecule #13: DNA-directed RNA polymerases I, II, and III subunit RPABC5

+
Macromolecule #14: DNA-directed RNA polymerases I and III subunit RPAC2

+
Macromolecule #15: DNA-directed RNA polymerases I, II, and III subunit RPABC4

+
Macromolecule #16: DNA-directed RNA polymerase III subunit RPC5

+
Macromolecule #17: DNA-directed RNA polymerase III subunit RPC4

+
Macromolecule #18: DNA-directed RNA polymerase III subunit RPC3

+
Macromolecule #19: DNA-directed RNA polymerase III subunit RPC6

+
Macromolecule #20: DNA-directed RNA polymerase III subunit RPC7

+
Macromolecule #21: TATA-box-binding protein

+
Macromolecule #22: Transcription factor IIIB 50 kDa subunit

+
Macromolecule #23: Transcription factor TFIIIB component B'' homolog

+
Macromolecule #24: DNA (82-MER)

+
Macromolecule #25: DNA (82-MER)

+
Macromolecule #26: ZINC ION

+
Macromolecule #27: MAGNESIUM ION

+
Macromolecule #28: IRON/SULFUR CLUSTER

-
Experimental details

-
Structure determination

-
Sample preparation

-
Electron microscopy

-
Image processing

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About Yorodumi

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Feb 9, 2022. New format data for meta-information of EMDB entries

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Yorodumi