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- EMDB-33684: The nucleosome-bound human PBAF complex -

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基本情報

登録情報
データベース: EMDB / ID: EMD-33684
タイトルThe nucleosome-bound human PBAF complex
マップデータPBAF overall map
試料
  • 複合体: Nucleosome-bound human PBAF complex
    • タンパク質・ペプチド: x 16種
    • DNA: x 2種
  • タンパク質・ペプチド: x 4種
  • リガンド: x 3種
キーワードchromatin remodeling complexes / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex
機能・相同性
機能・相同性情報


single stranded viral RNA replication via double stranded DNA intermediate / positive regulation of glucose mediated signaling pathway / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / bBAF complex / npBAF complex / nBAF complex / brahma complex / neural retina development ...single stranded viral RNA replication via double stranded DNA intermediate / positive regulation of glucose mediated signaling pathway / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / bBAF complex / npBAF complex / nBAF complex / brahma complex / neural retina development / negative regulation of androgen receptor signaling pathway / N-acetyltransferase activity / histone H3K14ac reader activity / GBAF complex / blastocyst hatching / EGR2 and SOX10-mediated initiation of Schwann cell myelination / nucleosome array spacer activity / regulation of G0 to G1 transition / hepatocyte differentiation / Tat protein binding / coronary artery morphogenesis / XY body / RSC-type complex / Ino80 complex / blastocyst formation / regulation of nucleotide-excision repair / RNA polymerase I preinitiation complex assembly / regulation of double-strand break repair / ATP-dependent chromatin remodeler activity / cellular response to fatty acid / host-mediated activation of viral transcription / nucleosome disassembly / germ cell nucleus / SWI/SNF complex / regulation of mitotic metaphase/anaphase transition / positive regulation of T cell differentiation / nuclear androgen receptor binding / positive regulation of double-strand break repair / nuclear chromosome / negative regulation of G1/S transition of mitotic cell cycle / homeostatic process / spinal cord development / NuA4 histone acetyltransferase complex / regulation of chromosome organization / positive regulation of stem cell population maintenance / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / Regulation of MITF-M-dependent genes involved in pigmentation / regulation of G1/S transition of mitotic cell cycle / regulation of DNA replication / regulation of embryonic development / negative regulation of cell differentiation / positive regulation of signal transduction by p53 class mediator / positive regulation of Wnt signaling pathway / cardiac muscle cell proliferation / positive regulation of myoblast differentiation / embryonic organ development / ATP-dependent activity, acting on DNA / heart morphogenesis / positive regulation of double-strand break repair via homologous recombination / histone acetyltransferase activity / regulation of DNA repair / Chromatin modifying enzymes / Packaging Of Telomere Ends / Regulation of TP53 Activity through Acetylation / : / DNA polymerase binding / neurogenesis / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Deposition of new CENPA-containing nucleosomes at the centromere / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / telomere maintenance / Interleukin-7 signaling / Inhibition of DNA recombination at telomere / RNA Polymerase I Promoter Opening / Meiotic synapsis / transcription initiation-coupled chromatin remodeling / Assembly of the ORC complex at the origin of replication / regulation of mitotic cell cycle / positive regulation of DNA repair / Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex / negative regulation of cell migration / DNA methylation / Condensation of Prophase Chromosomes / Chromatin modifications during the maternal to zygotic transition (MZT) / SIRT1 negatively regulates rRNA expression / HCMV Late Events / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / transcription coregulator binding / nuclear receptor binding / PRC2 methylates histones and DNA / Regulation of endogenous retroelements by KRAB-ZFP proteins / Defective pyroptosis / DNA Damage Recognition in GG-NER / Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) / transcription coregulator activity / positive regulation of cell differentiation / HDACs deacetylate histones / transcription elongation by RNA polymerase II
類似検索 - 分子機能
PHD finger protein 10 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / RFX DNA-binding domain / SWIB domain / SWI complex, BAF60b domains / SMARCC, SWIRM-associated domain / SMARCC, N-terminal / : / SWIRM-associated domain at the N-terminal / SWIRM-associated domain at the C-terminal ...PHD finger protein 10 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / RFX DNA-binding domain / SWIB domain / SWI complex, BAF60b domains / SMARCC, SWIRM-associated domain / SMARCC, N-terminal / : / SWIRM-associated domain at the N-terminal / SWIRM-associated domain at the C-terminal / MarR-like, BRCT and chromo domains module profile. / : / SWI/SNF Subunit INI1, DNA binding domain / : / SWI/SNF complex subunit BRG1 / DNA-binding RFX-type winged-helix domain / RFX-type winged-helix DNA-binding domain profile. / Chromatin-remodeling complex component Sfh1/SNF5 / Protein polybromo-1, Bromodomain 5 / SMARCC, C-terminal / SWIRM-associated region 1 / SNF5/SMARCB1/INI1 / SNF5 / SMARCB1 / INI1 / BRK domain / BRK domain / BRK domain superfamily / domain in transcription and CHROMO domain helicases / Remodelling complex subunit Rsc/polybromo / Protein of unknown function DUF3512 / Domain of unknown function (DUF3512) / Glutamine-Leucine-Glutamine, QLQ / QLQ / QLQ domain profile. / QLQ / : / Snf2-ATP coupling, chromatin remodelling complex / Snf2, ATP coupling domain / Snf2-ATP coupling, chromatin remodelling complex / domain in helicases and associated with SANT domains / HSA domain / ARID DNA-binding domain / ARID DNA-binding domain superfamily / ARID/BRIGHT DNA binding domain / ARID domain profile. / BRIGHT, ARID (A/T-rich interaction domain) domain / ARID/BRIGHT DNA binding domain / Helicase/SANT-associated domain / HSA domain profile. / SWIRM domain / SWIRM domain / SWIRM domain profile. / SWIB/MDM2 domain / SWIB/MDM2 domain / SWIB/MDM2 domain profile. / Bromo adjacent homology domain / BAH domain / Bromo adjacent homology (BAH) domain / SWIB/MDM2 domain superfamily / Bromo adjacent homology (BAH) domain superfamily / BAH domain profile. / HMG (high mobility group) box / SANT domain profile. / Chromo/chromo shadow domain / Chromatin organization modifier domain / HMG boxes A and B DNA-binding domains profile. / SANT domain / high mobility group / High mobility group box domain / High mobility group box domain superfamily / Myb-like DNA-binding domain / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / BRCT domain superfamily / PHD-finger / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / Zinc finger PHD-type signature. / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Zinc finger PHD-type profile. / : / Zinc finger, PHD-finger / Histone H2B signature. / Histone H2A conserved site / Histone H2A signature. / Histone H2B / Histone H2B / Histone H2A, C-terminal domain / C-terminus of histone H2A / Zinc finger, PHD-type
類似検索 - ドメイン・相同性
Histone H3 / ACTB protein / Histone H4 / Actin-like protein 6A / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 / AT-rich interactive domain-containing protein 2 / Protein polybromo-1 / SWI/SNF complex subunit SMARCC2 / PHD finger protein 10 ...Histone H3 / ACTB protein / Histone H4 / Actin-like protein 6A / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 / AT-rich interactive domain-containing protein 2 / Protein polybromo-1 / SWI/SNF complex subunit SMARCC2 / PHD finger protein 10 / Histone H2A type 1-C / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / Bromodomain-containing protein 7 / Histone H2B
類似検索 - 構成要素
生物種Homo sapiens (ヒト)
手法単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 4.4 Å
データ登録者Wang L / Yu J / Yu Z / Wang Q / He S / Xu Y
資金援助 中国, 2件
OrganizationGrant number国
National Natural Science Foundation of China (NSFC)32030055 中国
National Natural Science Foundation of China (NSFC) 中国
引用ジャーナル: Nat Commun / 年: 2022
タイトル: Structure of nucleosome-bound human PBAF complex.
著者: Li Wang / Jiali Yu / Zishuo Yu / Qianmin Wang / Wanjun Li / Yulei Ren / Zhenguo Chen / Shuang He / Yanhui Xu /
要旨: BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation. ...BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation. Despite previous structural studies and recent advance of SWI/SNF family complexes, it remains incompletely understood how PBAF-nucleosome complex is organized. Here we determined structure of 13-subunit human PBAF in complex with acetylated nucleosome in ADP-BeF-bound state. Four PBAF-specific subunits work together with nine BAF/PBAF-shared subunits to generate PBAF-specific modular organization, distinct from that of BAF at various regions. PBAF-nucleosome structure reveals six histone-binding domains and four DNA-binding domains/modules, the majority of which directly bind histone/DNA. This multivalent nucleosome-binding pattern, not observed in previous studies, suggests that PBAF may integrate comprehensive chromatin information to target genomic loci for function. Our study reveals molecular organization of subunits and histone/DNA-binding domains/modules in PBAF-nucleosome complex and provides structural insights into PBAF-mediated nucleosome association complimentary to the recently reported PBAF-nucleosome structure.
履歴
登録2022年6月24日-
ヘッダ(付随情報) 公開2022年12月7日-
マップ公開2022年12月7日-
更新2024年7月3日-
現状2024年7月3日処理サイト: PDBj / 状態: 公開

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構造の表示

添付画像

emd_33684.png

ダウンロードとリンク

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マップ

ファイルダウンロード / ファイル: emd_33684.map.gz / 形式: CCP4 / 大きさ: 178 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
注釈PBAF overall map
投影像・断面図

画像のコントロール

大きさ
明度
コントラスト
その他
軸Z (Sec.)Y (Row.)X (Col.)
1.33 Å/pix.
x 360 pix.
= 480.24 Å		1.33 Å/pix.
x 360 pix.
= 480.24 Å		1.33 Å/pix.
x 360 pix.
= 480.24 Å

表面

投影像

断面 (1/3)

断面 (1/2)

断面 (2/3)

画像は Spider により作成

ボクセルのサイズX=Y=Z: 1.334 Å
密度

ヒストグラム

ヒストグラム (対数)
表面レベル登録者による: 0.28
最小 - 最大-0.6439558 - 1.471982
平均 (標準偏差)-0.0019230427 (±0.053164065)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderXYZ
Origin000
サイズ360360360
Spacing360360360
セルA=B=C: 480.24 Å
α=β=γ: 90.0 °

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添付データ

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追加マップ: PBAF ARP module

ファイルemd_33684_additional_1.map
注釈PBAF ARP module
投影像・断面図
軸ZYX

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密度ヒストグラム

ヒストグラム

ヒストグラム (対数)

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追加マップ: PBAF ATPase module

ファイルemd_33684_additional_2.map
注釈PBAF ATPase module
投影像・断面図
軸ZYX

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密度ヒストグラム

ヒストグラム

ヒストグラム (対数)

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追加マップ: PBAF base module

ファイルemd_33684_additional_3.map
注釈PBAF base module
投影像・断面図
軸ZYX

投影像

断面 (1/2)
密度ヒストグラム

ヒストグラム

ヒストグラム (対数)

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ハーフマップ: PBAF overall half map

ファイルemd_33684_half_map_1.map
注釈PBAF overall half map
投影像・断面図
軸ZYX

投影像

断面 (1/2)
密度ヒストグラム

ヒストグラム

ヒストグラム (対数)

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ハーフマップ: PBAF overall half map

ファイルemd_33684_half_map_2.map
注釈PBAF overall half map
投影像・断面図
軸ZYX

投影像

断面 (1/2)
密度ヒストグラム

ヒストグラム

ヒストグラム (対数)

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試料の構成要素

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全体 : Nucleosome-bound human PBAF complex

全体名称: Nucleosome-bound human PBAF complex
要素
  • 複合体: Nucleosome-bound human PBAF complex
    • タンパク質・ペプチド: Histone H3
    • タンパク質・ペプチド: Histone H4
    • タンパク質・ペプチド: Histone H2A type 1-C
    • タンパク質・ペプチド: Histone H2B
    • タンパク質・ペプチド: ACTB protein (Fragment)
    • タンパク質・ペプチド: Actin-like protein 6A
    • タンパク質・ペプチド: AT-rich interactive domain-containing protein 2
    • タンパク質・ペプチド: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
    • タンパク質・ペプチド: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
    • タンパク質・ペプチド: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
    • タンパク質・ペプチド: PHD finger protein 10
    • タンパク質・ペプチド: Bromodomain-containing protein 7
    • タンパク質・ペプチド: Unkown
    • タンパク質・ペプチド: Protein polybromo-1
    • タンパク質・ペプチド: Unknown
    • DNA: DNA (213-MER)
    • DNA: DNA (213-MER)
    • タンパク質・ペプチド: Unknown
  • タンパク質・ペプチド: Unknown
  • タンパク質・ペプチド: Transcription activator BRG1
  • タンパク質・ペプチド: SWI/SNF complex subunit SMARCC2
  • タンパク質・ペプチド: Unknown
  • リガンド: ADENOSINE-5'-DIPHOSPHATE
  • リガンド: MAGNESIUM ION
  • リガンド: BERYLLIUM TRIFLUORIDE ION

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超分子 #1: Nucleosome-bound human PBAF complex

超分子名称: Nucleosome-bound human PBAF complex / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1-#4, #7-#10, #13-#22
由来(天然)生物種: Homo sapiens (ヒト)

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分子 #1: Histone H3

分子名称: Histone H3 / タイプ: protein_or_peptide / ID: 1 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 15.305969 KDa
組換発現生物種: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (大腸菌)
配列文字列:
ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA

UniProtKB: Histone H3

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分子 #2: Histone H4

分子名称: Histone H4 / タイプ: protein_or_peptide / ID: 2 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 11.263231 KDa
組換発現生物種: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (大腸菌)
配列文字列:
SGRGKGGKGL GKGGAKRHRK VLRDNIQGIT KPAIRRLARR GGVKRISGLI YEETRGVLKV FLENVIRDAV TYTEHAKRKT VTAMDVVYA LKRQGRTLYG FGG

UniProtKB: Histone H4

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分子 #3: Histone H2A type 1-C

分子名称: Histone H2A type 1-C / タイプ: protein_or_peptide / ID: 3 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 14.004329 KDa
組換発現生物種: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (大腸菌)
配列文字列:
SGRGKQGGKA RAKAKSRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK TESHHKAKGK

UniProtKB: Histone H2A type 1-C

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分子 #4: Histone H2B

分子名称: Histone H2B / タイプ: protein_or_peptide / ID: 4 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 13.806018 KDa
組換発現生物種: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (大腸菌)
配列文字列:
PEPAKSAPAP KKGSKKAVTK AQKKDGKKRK RSRKESYSVY VYKVLKQVHP DTGISSKAMG IMNSFVNDIF ERIAGEASRL AHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK

UniProtKB: Histone H2B

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分子 #5: Unknown

分子名称: Unknown / タイプ: protein_or_peptide / ID: 5 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 2.486056 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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分子 #6: Transcription activator BRG1

分子名称: Transcription activator BRG1 / タイプ: protein_or_peptide / ID: 6 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 184.923828 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG PGGYPQDNMH QMHKPMESMH EKGMSDDPR YNQMKGMGMR SGGHAGMGPP PSPMDQHSQG YPSPLGGSEH ASSPVPASGP SSGPQMSSGP GGAPLDGADP Q ALGQQNRG ...文字列:
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG PGGYPQDNMH QMHKPMESMH EKGMSDDPR YNQMKGMGMR SGGHAGMGPP PSPMDQHSQG YPSPLGGSEH ASSPVPASGP SSGPQMSSGP GGAPLDGADP Q ALGQQNRG PTPFNQNQLH QLRAQIMAYK MLARGQPLPD HLQMAVQGKR PMPGMQQQMP TLPPPSVSAT GPGPGPGPGP GP GPGPAPP NYSRPHGMGG PNMPPPGPSG VPPGMPGQPP GGPPKPWPEG PMANAAAPTS TPQKLIPPQP TGRPSPAPPA VPP AASPVM PPQTQSPGQP AQPAPMVPLH QKQSRITPIQ KPRGLDPVEI LQEREYRLQA RIAHRIQELE NLPGSLAGDL RTKA TIELK ALRLLNFQRQ LRQEVVVCMR RDTALETALN AKAYKRSKRQ SLREARITEK LEKQQKIEQE RKRRQKHQEY LNSIL QHAK DFKEYHRSVT GKIQKLTKAV ATYHANTERE QKKENERIEK ERMRRLMAED EEGYRKLIDQ KKDKRLAYLL QQTDEY VAN LTELVRQHKA AQVAKEKKKK KKKKKAENAE GQTPAIGPDG EPLDETSQMS DLPVKVIHVE SGKILTGTDA PKAGQLE AW LEMNPGYEVA PRSDSEESGS EEEEEEEEEE QPQAAQPPTL PVEEKKKIPD PDSDDVSEVD ARHIIENAKQ DVDDEYGV S QALARGLQSY YAVAHAVTER VDKQSALMVN GVLKQYQIKG LEWLVSLYNN NLNGILADEM GLGKTIQTIA LITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNH HCKLTQVLNT HYVAPRRLLL TGTPLQNKLP ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGEKVDLNEE E TILIIRRL HKVLRPFLLR RLKKEVEAQL PEKVEYVIKC DMSALQRVLY RHMQAKGVLL TDGSEKDKKG KGGTKTLMNT IM QLRKICN HPYMFQHIEE SFSEHLGFTG GIVQGLDLYR ASGKFELLDR ILPKLRATNH KVLLFCQMTS LMTIMEDYFA YRG FKYLRL DGTTKAEDRG MLLKTFNEPG SEYFIFLLST RAGGLGLNLQ SADTVIIFDS DWNPHQDLQA QDRAHRIGQQ NEVR VLRLC TVNSVEEKIL AAAKYKLNVD QKVIQAGMFD QKSSSHERRA FLQAILEHEE QDESRHCSTG SGSASFAHTA PPPAG VNPD LEEPPLKEED EVPDDETVNQ MIARHEEEFD LFMRMDLDRR REEARNPKRK PRLMEEDELP SWIIKDDAEV ERLTCE EEE EKMFGRGSRH RKEVDYSDSL TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR KRDSDAGSST PTTSTRSRDK DDESKKQ KK RGRPPAEKLS PNPPNLTKKM KKIVDAVIKY KDSSSGRQLS EVFIQLPSRK ELPEYYELIR KPVDFKKIKE RIRNHKYR S LNDLEKDVML LCQNAQTFNL EGSLIYEDSI VLQSVFTSVR QKIEKEDDSE GEESEEEEEG EEEGSESESR SVKVKIKLG RKEKAQDRLK GGRRRPSRGS RAKPVVSDDD SEEEQEEDRS GSGSEED

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

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分子 #7: ACTB protein (Fragment)

分子名称: ACTB protein (Fragment) / タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 41.78266 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV T HTVPIYEG ...文字列:
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV T HTVPIYEG YALPHAILRL DLAGRDLTDY LMKILTERGY SFTTTAEREI VRDIKEKLCY VALDFEQEMA TAASSSSLEK SY ELPDGQV ITIGNERFRC PEALFQPSFL GMESCGIHET TFNSIMKCDV DIRKDLYANT VLSGGTTMYP GIADRMQKEI TAL APSTMK IKIIAPPERK YSVWIGGSIL ASLSTFQQMW ISKQEYDESG PSIVHRKCF

UniProtKB: ACTB protein

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分子 #8: Actin-like protein 6A

分子名称: Actin-like protein 6A / タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 47.509812 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP VLMSEAPWNT RAKREKLTEL MFEHYNIPAF FLCKTAVLTA F ANGRSTGL ...文字列:
MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP VLMSEAPWNT RAKREKLTEL MFEHYNIPAF FLCKTAVLTA F ANGRSTGL ILDSGATHTT AIPVHDGYVL QQGIVKSPLA GDFITMQCRE LFQEMNIELV PPYMIASKEA VREGSPANWK RK EKLPQVT RSWHNYMCNC VIQDFQASVL QVSDSTYDEQ VAAQMPTVHY EFPNGYNCDF GAERLKIPEG LFDPSNVKGL SGN TMLGVS HVVTTSVGMC DIDIRPGLYG SVIVAGGNTL IQSFTDRLNR ELSQKTPPSM RLKLIANNTT VERRFSSWIG GSIL ASLGT FQQMWISKQE YEEGGKQCVE RKCP

UniProtKB: Actin-like protein 6A

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分子 #9: AT-rich interactive domain-containing protein 2

分子名称: AT-rich interactive domain-containing protein 2 / タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 197.581094 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFAL KQYYLRYLEK YEKVHHFGED DDEVPPGNPK PQLPIGAIPS SYNYQQHSVS DYLRQSYGLS MDFNSPNDYN K LVLSLLSG ...文字列:
MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFAL KQYYLRYLEK YEKVHHFGED DDEVPPGNPK PQLPIGAIPS SYNYQQHSVS DYLRQSYGLS MDFNSPNDYN K LVLSLLSG LPNEVDFAIN VCTLLSNESK HVMQLEKDPK IITLLLANAG VFDDTLGSFS TVFGEEWKEK TDRDFVKFWK DI VDDNEVR DLISDRNKSH EGTSGEWIWE SLFHPPRKLG INDIEGQRVL QIAVILRNLS FEEGNVKLLA ANRTCLRFLL LSA HSHFIS LRQLGLDTLG NIAAELLLDP VDFKTTHLMF HTVTKCLMSR DRFLKMRGME ILGNLCKAED NGVLICEYVD QDSY REIIC HLTLPDVLLV ISTLEVLYML TEMGDVACTK IAKVEKSIDM LVCLVSMDIQ MFGPDALAAV KLIEHPSSSH QMLSE IRPQ AIEQVQTQTH VASAPASRAV VAQHVAPPPG IVEIDSEKFA CQWLNAHFEV NPDCSVSRAE MYSEYLSTCS KLARGG ILT STGFYKCLRT VFPNHTVKRV EDSSSNGQAH IHVVGVKRRA IPLPIQMYYQ QQPVSTSVVR VDSVPDVSPA PSPAGIP HG SQTIGNHFQR TPVANQSSNL TATQMSFPVQ GVHTVAQTVS RIPQNPSPHT HQQQNAPVTV IQSKAPIPCE VVKATVIQ N SIPQTGVPVS IAVGGGPPQS SVVQNHSTGP QPVTVVNSQT LLHHPSVIPQ QSPLHTVVPG QIPSGTPVTV IQQAVPQSH MFGRVQNIPA CTSTVSQGQQ LITTSPQPVQ TSSQQTSAGS QSQDTVIIAP PQYVTTSASN IVSATSVQNF QVATGQMVTI AGVPSPQAS RVGFQNIAPK PLPSQQVSST VVQQPIQQPQ QPTQQSVVIV SQPAQQGQTY APAIHQIVLA NPAALPAGQT V QLTGQPNI TPSSSPSPVP ATNNQVPTAM SSSSTPQSQG PPPTVSQMLS VKRQQQQQHS PAPPPQQVQV QVQQPQQVQM QV QPQQSNA GVGQPASGES SLIKQLLLPK RGPSTPGGKL ILPAPQIPPP NNARAPSPQV VYQVASNQAA GFGVQGQTPA QQL LVGQQN VQLVPSAMPP SGGVQTVPIS NLQILPGPLI SNSPATIFQG TSGNQVTITV VPNTSFAPAT VSQGNATQLI APAG ITMSG TQTGVGLPVQ TLPATQASPA GQSSCTTATP PFKGDKIICQ KEEEAKEATG LHVHERKIEV MENPSCRRGA TNTSN GDTK ENEMHVGSLL NGRKYSDSSL PPSNSGKIQS ETNQCSLISN GPSLELGENG ASGKQNSEQI DMQDIKSDLR KPLVNG ICD FDKGDGSHLS KNIPNHKTSN HVGNGEISPM EPQGTLDITQ QDTAKGDQLE RISNGPVLTL GGSSVSSIQE ASNAATQ QF SGTDLLNGPL ASSLNSDVPQ QRPSVVVSPH STTSVIQGHQ IIAVPDSGSK VSHSPALSSD VRSTNGTAEC KTVKRPAE D TDRETVAGIP NKVGVRIVTI SDPNNAGCSA TMVAVPAGAD PSTVAKVAIE SAVQQKQQHP PTYVQNVVPQ NTPMPPSPA VQVQGQPNSS QPSPFSGSSQ PGDPMRKPGQ NFMCLWQSCK KWFQTPSQVF YHAATEHGGK DVYPGQCLWE GCEPFQRQRF SFITHLQDK HCSKDALLAG LKQDEPGQAG SQKSSTKQPT VGGTSSTPRA QKAIVNHPSA ALMALRRGSR NLVFRDFTDE K EGPITKHI RLTAALILKN IGKYSECGRR LLKRHENNLS VLAISNMEAS STLAKCLYEL NFTVQSKEQE KDSEMLQ

UniProtKB: AT-rich interactive domain-containing protein 2

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分子 #10: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

分子名称: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 44.199188 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MMMMALSKTF GQKPVKFQLE DDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER KKIVASSHGK KTKPNTKDHG YTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST TINRNRMGRD K KRTFPLCF ...文字列:
MMMMALSKTF GQKPVKFQLE DDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER KKIVASSHGK KTKPNTKDHG YTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST TINRNRMGRD K KRTFPLCF DDHDPAVIHE NASQPEVLVP IRLDMEIDGQ KLRDAFTWNM NEKLMTPEMF SEILCDDLDL NPLTFVPAIA SA IRQQIES YPTDSILEDQ SDQRVIIKLN IHVGNISLVD QFEWDMSEKE NSPEKFALKL CSELGLGGEF VTTIAYSIRG QLS WHQKTY AFSENPLPTV EIAIRNTGDA DQWCPLLETL TDAEMEKKIR DQDRNTRRMR RLANTAPAW

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

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分子 #11: SWI/SNF complex subunit SMARCC2

分子名称: SWI/SNF complex subunit SMARCC2 / タイプ: protein_or_peptide / ID: 11 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 133.048109 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGS LCHILAAAYK FKSDQGWRRY DFQNPSRMDR NVEMFMTIEK SLVQNNCLSR PNIFLCPEIE PKLLGKLKDI I KRHQGTVT ...文字列:
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGS LCHILAAAYK FKSDQGWRRY DFQNPSRMDR NVEMFMTIEK SLVQNNCLSR PNIFLCPEIE PKLLGKLKDI I KRHQGTVT EDKNNASHVV YPVPGNLEEE EWVRPVMKRD KQVLLHWGYY PDSYDTWIPA SEIEASVEDA PTPEKPRKVH AK WILDTDT FNEWMNEEDY EVNDDKNPVS RRKKISAKTL TDEVNSPDSD RRDKKGGNYK KRKRSPSPSP TPEAKKKNAK KGP STPYTK SKRGHREEEQ EDLTKDMDEP SPVPNVEEVT LPKTVNTKKD SESAPVKGGT MTDLDEQEDE SMETTGKDED ENST GNKGE QTKNPDLHED NVTEQTHHII IPSYAAWFDY NSVHAIERRA LPEFFNGKNK SKTPEIYLAY RNFMIDTYRL NPQEY LTST ACRRNLAGDV CAIMRVHAFL EQWGLINYQV DAESRPTPMG PPPTSHFHVL ADTPSGLVPL QPKTPQQTSA SQQMLN FPD KGKEKPTDMQ NFGLRTDMYT KKNVPSKSKA AASATREWTE QETLLLLEAL EMYKDDWNKV SEHVGSRTQD ECILHFL RL PIEDPYLEDS EASLGPLAYQ PIPFSQSGNP VMSTVAFLAS VVDPRVASAA AKSALEEFSK MKEEVPTALV EAHVRKVE E AAKVTGKADP AFGLESSGIA GTTSDEPERI EESGNDEARV EGQATDEKKE PKEPREGGGA IEEEAKEKTS EAPKKDEEK GKEGDSEKES EKSDGDPIVD PEKEKEPKEG QEEVLKEVVE SEGERKTKVE RDIGEGNLST AAAAALAAAA VKAKHLAAVE ERKIKSLVA LLVETQMKKL EIKLRHFEEL ETIMDREREA LEYQRQQLLA DRQAFHMEQL KYAEMRARQQ HFQQMHQQQQ Q PPPALPPG SQPIPPTGAA GPPAVHGLAV APASVVPAPA GSGAPPGSLG PSEQIGQAGS TAGPQQQQPA GAPQPGAVPP GV PPPGPHG PSPFPNQQTP PSMMPGAVPG SGHPGVAGNA PLGLPFGMPP PPPPPAPSII PFGSLADSIS INLPAPPNLH GHH HHLPFA PGTLPPPNLP VSMANPLHPN LPATTTMPSS LPLGPGLGSA AAQSPAIVAA VQGNLLPSAS PLPDPGTPLP PDPT APSPG TVTPVPPPQ

UniProtKB: SWI/SNF complex subunit SMARCC2

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分子 #12: Unknown

分子名称: Unknown / タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 1.039273 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)

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分子 #13: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

分子名称: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
タイプ: protein_or_peptide / ID: 13 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 58.311391 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRP GLAQSGMDQS RKRPAPQQIQ QVQQQAVQNR NHNAKKKKMA DKILPQRIRE LVPESQAYMD LLAFERKLDQ T IMRKRLDI ...文字列:
MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRP GLAQSGMDQS RKRPAPQQIQ QVQQQAVQNR NHNAKKKKMA DKILPQRIRE LVPESQAYMD LLAFERKLDQ T IMRKRLDI QEALKRPIKQ KRKLRIFISN TFNPAKSDAE DGEGTVASWE LRVEGRLLED SALSKYDATK QKRKFSSFFK SL VIELDKD LYGPDNHLVE WHRTATTQET DGFQVKRPGD VNVRCTVLLM LDYQPPQFKL DPRLARLLGI HTQTRPVIIQ ALW QYIKTH KLQDPHEREF VICDKYLQQI FESQRMKFSE IPQRLHALLM PPEPIIINHV ISVDPNDQKK TACYDIDVEV DDTL KTQMN SFLLSTASQQ EIATLDNKIH ETIETINQLK TQREFMLSFA RDPQGFINDW LQSQCRDLKT MTDVVGNPEE ERRAE FYFQ PWAQEAVCRY FYSKVQQRRQ ELEQALGIRN T

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

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分子 #14: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

分子名称: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
タイプ: protein_or_peptide / ID: 14 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 46.710371 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNP DLKLWEIGKI IGGMWRDLTD EEKQEYLNEY EAEKIEYNES MKAYHNSPAY LAYINAKSRA EAALEEESRQ R QSRMEKGE ...文字列:
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNP DLKLWEIGKI IGGMWRDLTD EEKQEYLNEY EAEKIEYNES MKAYHNSPAY LAYINAKSRA EAALEEESRQ R QSRMEKGE PYMSIQPAED PDDYDDGFSM KHTATARFQR NHRLISEILS ESVVPDVRSV VTTARMQVLK RQVQSLMVHQ RK LEAELLQ IEERHQEKKR KFLESTDSFN NELKRLCGLK VEVDMEKIAA EIAQAEEQAR KRQEEREKEA AEQAERSQSS IVP EEEQAA NKGEEKKDDE NIPMETEETH LEETTESQQN GEEGTSTPED KESGQEGVDS MAEEGTSDSN TGSESNSATV EEPP TDPIP EDEKKE

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

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分子 #15: PHD finger protein 10

分子名称: PHD finger protein 10 / タイプ: protein_or_peptide / ID: 15 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 56.131855 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS SQDLGFSYYP AENLIEYKWP PDETGEYYM LQEQVSEYLG VTSFKRKYPD LERRDLSHKE KLYLRELNVI TETQCTLGLT ALRSDEVIDL MIKEYPAKHA E YSVILQEK ...文字列:
MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS SQDLGFSYYP AENLIEYKWP PDETGEYYM LQEQVSEYLG VTSFKRKYPD LERRDLSHKE KLYLRELNVI TETQCTLGLT ALRSDEVIDL MIKEYPAKHA E YSVILQEK ERQRITDHYK EYSQMQQQNT QKVEASKVPE YIKKAAKKAA EFNSNLNRER MEERRAYFDL QTHVIQVPQG KY KVLPTER TKVSSYPVAL IPGQFQEYYK RYSPDELRYL PLNTALYEPP LDPELPALDS DGDSDDGEDG RGDEKRKNKG TSD SSSGNV SEGESPPDSQ EDSFQGRQKS KDKAATPRKD GPKRSVLSKS VPGYKPKVIP NAICGICLKG KESNKKGKAE SLIH CSQCE NSGHPSCLDM TMELVSMIKT YPWQCMECKT CIICGQPHHE EEMMFCDMCD RGYHTFCVGL GAIPSGRWIC DCCQR APPT PRKVGRRGKN SKEG

UniProtKB: PHD finger protein 10

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分子 #16: Bromodomain-containing protein 7

分子名称: Bromodomain-containing protein 7 / タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 74.257688 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP V TDFIAPGY ...文字列:
MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP V TDFIAPGY SMIIKHPMDF STMKEKIKNN DYQSIEELKD NFKLMCTNAM IYNKPETIYY KAAKKLLHSG MKILSQERIQ SL KQSIDFM ADLQKTRKQK DGTDTSQSGE DGGCWQRERE DSGDAEAHAF KSPSKENKKK DKDMLEDKFK SNNLEREQEQ LDR IVKESG GKLTRRLVNS QCEFERRKPD GTTTLGLLHP VDPIVGEPGY CPVRLGMTTG RLQSGVNTLQ GFKEDKRNKV TPVL YLNYG PYSSYAPHYD STFANISKDD SDLIYSTYGE DSDLPSDFSI HEFLATCQDY PYVMADSLLD VLTKGGHSRT LQEME MSLP EDEGHTRTLD TAKEMEITEV EPPGRLDSST QDRLIALKAV TNFGVPVEVF DSEEAEIFQK KLDETTRLLR ELQEAQ NER LSTRPPPNMI CLLGPSYREM HLAEQVTNNL KELAQQVTPG DIVSTYGVRK AMGISIPSPV MENNFVDLTE DTEEPKK TD VAECGPGGS

UniProtKB: Bromodomain-containing protein 7

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分子 #17: Unkown

分子名称: Unkown / タイプ: protein_or_peptide / ID: 17 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 1.890321 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)

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分子 #18: Protein polybromo-1

分子名称: Protein polybromo-1 / タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 184.157281 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVS QPIDLMKIQQ KLKMEEYDDV NLLTADFQLL FNNAKSYYKP DSPEYKAACK LWDLYLRTRN EFVQKGEADD E DDDEDGQD ...文字列:
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVS QPIDLMKIQQ KLKMEEYDDV NLLTADFQLL FNNAKSYYKP DSPEYKAACK LWDLYLRTRN EFVQKGEADD E DDDEDGQD NQGTVTEGSS PAYLKEILEQ LLEAIVVATN PSGRLISELF QKLPSKVQYP DYYAIIKEPI DLKTIAQRIQ NG SYKSIHA MAKDIDLLAK NAKTYNEPGS QVFKDANSIK KIFYMKKAEI EHHEMAKSSL RMRTPSNLAA ARLTGPSHSK GSL GEERNP TSKYYRNKRA VQGGRLSAIT MALQYGSESE EDAALAAARY EEGESEAESI TSFMDVSNPF YQLYDTVRSC RNNQ GQLIA EPFYHLPSKK KYPDYYQQIK MPISLQQIRT KLKNQEYETL DHLECDLNLM FENAKRYNVP NSAIYKRVLK LQQVM QAKK KELARRDDIE DGDSMISSAT SDTGSAKRKR NTHDSEMLGL RRLSSKKNIR KQRMKILFNV VLEAREPGSG RRLCDL FMV KPSKKDYPDY YKIILEPMDL KIIEHNIRND KYAGEEGMIE DMKLMFRNAR HYNEEGSQVY NDAHILEKLL KEKRKEL GP LPDDDDMASP KLKLSRKSGI SPKKSKYMTP MQQKLNEVYE AVKNYTDKRG RRLSAIFLRL PSRSELPDYY LTIKKPMD M EKIRSHMMAN KYQDIDSMVE DFVMMFNNAC TYNEPESLIY KDALVLHKVL LETRRDLEGD EDSHVPNVTL LIQELIHNL FVSVMSHQDD EGRCYSDSLA EIPAVDPNFP NKPPLTFDII RKNVENNRYR RLDLFQEHMF EVLERARRMN RTDSEIYEDA VELQQFFIK IRDELCKNGE ILLSPALSYT TKHLHNDVEK ERKEKLPKEI EEDKLKREEE KREAEKSEDS SGAAGLSGLH R TYSQDCSF KNSMYHVGDY VYVEPAEANL QPHIVCIERL WEDSAGEKWL YGCWFYRPNE TFHLATRKFL EKEVFKSDYY NK VPVSKIL GKCVVMFVKE YFKLCPENFR DEDVFVCESR YSAKTKSFKK IKLWTMPISS VRFVPRDVPL PVVRVASVFA NAD KGDDEK NTDNSEDSRA EDNFNLEKEK EDVPVEMSNG EPGCHYFEQL HYNDMWLKVG DCVFIKSHGL VRPRVGRIEK VWVR DGAAY FYGPIFIHPE ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP ENDILLCESR YNESD KQMK KFKGLKRFSL SAKVVDDEIY YFRKPIVPQK EPSPLLEKKI QLLEAKFAEL EGGDDDIEEM GEEDSEVIEP PSLPQL QTP LASELDLMPY TPPQSTPKSA KGSAKKEGSK RKINMSGYIL FSSEMRAVIK AQHPDYSFGE LSRLVGTEWR NLETAKK AE YEGVMNQGVA PMVGTPAPGG SPYGQQVGVL GPPGQQAPPP YPGPHPAGPP VIQQPTTPMF VAPPPKTQRL LHSEAYLK Y IEGLSAESNS ISKWDQTLAA RRRDVHLSKE QESRLPSHWL KSKGAHTTMA DALWRLRDLM LRDTLNIRQA YNLENV

UniProtKB: Protein polybromo-1

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分子 #19: Unknown

分子名称: Unknown / タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 8.698714 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) ...文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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分子 #22: Unknown

分子名称: Unknown / タイプ: protein_or_peptide / ID: 22 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 2.060531 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)

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分子 #20: DNA (213-MER)

分子名称: DNA (213-MER) / タイプ: dna / ID: 20 / コピー数: 1 / 分類: DNA
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 65.534699 KDa
配列文字列: (DA)(DT)(DC)(DC)(DT)(DG)(DG)(DG)(DG)(DA) (DA)(DT)(DT)(DC)(DC)(DC)(DT)(DG)(DG)(DA) (DG)(DA)(DA)(DT)(DC)(DC)(DC)(DG)(DG) (DT)(DG)(DC)(DC)(DG)(DA)(DG)(DG)(DC)(DC) (DG) (DC)(DT)(DC)(DA)(DA) ...文字列:
(DA)(DT)(DC)(DC)(DT)(DG)(DG)(DG)(DG)(DA) (DA)(DT)(DT)(DC)(DC)(DC)(DT)(DG)(DG)(DA) (DG)(DA)(DA)(DT)(DC)(DC)(DC)(DG)(DG) (DT)(DG)(DC)(DC)(DG)(DA)(DG)(DG)(DC)(DC) (DG) (DC)(DT)(DC)(DA)(DA)(DT)(DT)(DG) (DG)(DT)(DC)(DG)(DT)(DA)(DG)(DA)(DC)(DA) (DG)(DC) (DT)(DC)(DT)(DA)(DG)(DC)(DA) (DC)(DC)(DG)(DC)(DT)(DT)(DA)(DA)(DA)(DC) (DG)(DC)(DA) (DC)(DG)(DT)(DA)(DC)(DG) (DC)(DG)(DC)(DT)(DG)(DT)(DC)(DC)(DC)(DC) (DC)(DG)(DC)(DG) (DT)(DT)(DT)(DT)(DA) (DA)(DC)(DC)(DG)(DC)(DC)(DA)(DA)(DG)(DG) (DG)(DG)(DA)(DT)(DT) (DA)(DC)(DT)(DC) (DC)(DC)(DT)(DA)(DG)(DT)(DC)(DT)(DC)(DC) (DA)(DG)(DG)(DC)(DA)(DC) (DG)(DT)(DG) (DT)(DC)(DA)(DC)(DA)(DT)(DA)(DT)(DA)(DT) (DA)(DC)(DA)(DT)(DC)(DC)(DT) (DG)(DT) (DT)(DC)(DC)(DA)(DG)(DT)(DG)(DC)(DC)(DG) (DG)(DT)(DG)(DT)(DC)(DG)(DC)(DT) (DT) (DG)(DG)(DG)(DT)(DC)(DC)(DC)(DG)(DA)(DG) (DG)(DA)(DT)(DT)(DA)(DC)(DA)(DA)(DG) (DC)(DT)(DT)(DA)(DT)(DC)(DG)(DA)(DT)(DA) (DG)(DA)(DT)

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分子 #21: DNA (213-MER)

分子名称: DNA (213-MER) / タイプ: dna / ID: 21 / コピー数: 1 / 分類: DNA
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 65.998055 KDa
配列文字列: (DA)(DT)(DC)(DT)(DA)(DT)(DC)(DG)(DA)(DT) (DA)(DA)(DG)(DC)(DT)(DT)(DG)(DT)(DA)(DA) (DT)(DC)(DC)(DT)(DC)(DG)(DG)(DG)(DA) (DC)(DC)(DC)(DA)(DA)(DG)(DC)(DG)(DA)(DC) (DA) (DC)(DC)(DG)(DG)(DC) ...文字列:
(DA)(DT)(DC)(DT)(DA)(DT)(DC)(DG)(DA)(DT) (DA)(DA)(DG)(DC)(DT)(DT)(DG)(DT)(DA)(DA) (DT)(DC)(DC)(DT)(DC)(DG)(DG)(DG)(DA) (DC)(DC)(DC)(DA)(DA)(DG)(DC)(DG)(DA)(DC) (DA) (DC)(DC)(DG)(DG)(DC)(DA)(DC)(DT) (DG)(DG)(DA)(DA)(DC)(DA)(DG)(DG)(DA)(DT) (DG)(DT) (DA)(DT)(DA)(DT)(DA)(DT)(DG) (DT)(DG)(DA)(DC)(DA)(DC)(DG)(DT)(DG)(DC) (DC)(DT)(DG) (DG)(DA)(DG)(DA)(DC)(DT) (DA)(DG)(DG)(DG)(DA)(DG)(DT)(DA)(DA)(DT) (DC)(DC)(DC)(DC) (DT)(DT)(DG)(DG)(DC) (DG)(DG)(DT)(DT)(DA)(DA)(DA)(DA)(DC)(DG) (DC)(DG)(DG)(DG)(DG) (DG)(DA)(DC)(DA) (DG)(DC)(DG)(DC)(DG)(DT)(DA)(DC)(DG)(DT) (DG)(DC)(DG)(DT)(DT)(DT) (DA)(DA)(DG) (DC)(DG)(DG)(DT)(DG)(DC)(DT)(DA)(DG)(DA) (DG)(DC)(DT)(DG)(DT)(DC)(DT) (DA)(DC) (DG)(DA)(DC)(DC)(DA)(DA)(DT)(DT)(DG)(DA) (DG)(DC)(DG)(DG)(DC)(DC)(DT)(DC) (DG) (DG)(DC)(DA)(DC)(DC)(DG)(DG)(DG)(DA)(DT) (DT)(DC)(DT)(DC)(DC)(DA)(DG)(DG)(DG) (DA)(DA)(DT)(DT)(DC)(DC)(DC)(DC)(DA)(DG) (DG)(DA)(DT)

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分子 #23: ADENOSINE-5'-DIPHOSPHATE

分子名称: ADENOSINE-5'-DIPHOSPHATE / タイプ: ligand / ID: 23 / コピー数: 1 / 式: ADP
分子量理論値: 427.201 Da
Chemical component information

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP / ADP, エネルギー貯蔵分子*YM

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分子 #24: MAGNESIUM ION

分子名称: MAGNESIUM ION / タイプ: ligand / ID: 24 / コピー数: 1 / 式: MG
分子量理論値: 24.305 Da

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分子 #25: BERYLLIUM TRIFLUORIDE ION

分子名称: BERYLLIUM TRIFLUORIDE ION / タイプ: ligand / ID: 25 / コピー数: 1 / 式: BEF
分子量理論値: 66.007 Da
Chemical component information

ChemComp-BEF:
BERYLLIUM TRIFLUORIDE ION

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析単粒子再構成法
試料の集合状態particle

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試料調製

緩衝液pH: 8
凍結凍結剤: ETHANE

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電子顕微鏡法

顕微鏡FEI TITAN KRIOS
撮影フィルム・検出器のモデル: GATAN K3 (6k x 4k) / 平均電子線量: 50.0 e/Å2
電子線加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
電子光学系照射モード: OTHER / 撮影モード: BRIGHT FIELD / 最大 デフォーカス（公称値）: 2.5 µm / 最小 デフォーカス（公称値）: 1.0 µm
実験機器
モデル: Titan Krios / 画像提供: FEI Company

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画像解析

初期モデルモデルのタイプ: NONE
最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 4.4 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 37528
初期 角度割当タイプ: MAXIMUM LIKELIHOOD
最終 角度割当タイプ: MAXIMUM LIKELIHOOD

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る