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- EMDB-31465: human delta-METTL18 60S ribosome -

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基本情報

登録情報
データベース: EMDB / ID: EMD-31465
タイトルhuman delta-METTL18 60S ribosome
マップデータ
試料
  • 複合体: 60S
    • タンパク質・ペプチド: x 42種
    • RNA: x 3種
  • リガンド: x 3種
機能・相同性
機能・相同性情報


translation at presynapse / embryonic brain development / exit from mitosis / eukaryotic 80S initiation complex / negative regulation of protein neddylation / optic nerve development / response to insecticide / regulation of translation involved in cellular response to UV / axial mesoderm development / negative regulation of formation of translation preinitiation complex ...translation at presynapse / embryonic brain development / exit from mitosis / eukaryotic 80S initiation complex / negative regulation of protein neddylation / optic nerve development / response to insecticide / regulation of translation involved in cellular response to UV / axial mesoderm development / negative regulation of formation of translation preinitiation complex / regulation of G1 to G0 transition / ribosomal protein import into nucleus / 90S preribosome assembly / protein-DNA complex disassembly / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / retinal ganglion cell axon guidance / GAIT complex / positive regulation of DNA damage response, signal transduction by p53 class mediator / TORC2 complex binding / alpha-beta T cell differentiation / G1 to G0 transition / middle ear morphogenesis / cytoplasmic side of rough endoplasmic reticulum membrane / negative regulation of ubiquitin protein ligase activity / homeostatic process / macrophage chemotaxis / lung morphogenesis / positive regulation of natural killer cell proliferation / Protein hydroxylation / Peptide chain elongation / Selenocysteine synthesis / Formation of a pool of free 40S subunits / Eukaryotic Translation Termination / ubiquitin ligase inhibitor activity / blastocyst development / cellular response to actinomycin D / Response of EIF2AK4 (GCN2) to amino acid deficiency / SRP-dependent cotranslational protein targeting to membrane / negative regulation of ubiquitin-dependent protein catabolic process / positive regulation of signal transduction by p53 class mediator / Viral mRNA Translation / Maturation of protein E / Maturation of protein E / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / protein localization to nucleus / GTP hydrolysis and joining of the 60S ribosomal subunit / ER Quality Control Compartment (ERQC) / Myoclonic epilepsy of Lafora / FLT3 signaling by CBL mutants / Prevention of phagosomal-lysosomal fusion / L13a-mediated translational silencing of Ceruloplasmin expression / IRAK2 mediated activation of TAK1 complex / Alpha-protein kinase 1 signaling pathway / Glycogen synthesis / positive regulation of protein binding / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / Membrane binding and targetting of GAG proteins / Endosomal Sorting Complex Required For Transport (ESCRT) / Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 / Negative regulation of FLT3 / PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 / Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation / Constitutive Signaling by NOTCH1 HD Domain Mutants / IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation / NOTCH2 Activation and Transmission of Signal to the Nucleus / Major pathway of rRNA processing in the nucleolus and cytosol / TICAM1,TRAF6-dependent induction of TAK1 complex / protein targeting / TICAM1-dependent activation of IRF3/IRF7 / APC/C:Cdc20 mediated degradation of Cyclin B / Regulation of FZD by ubiquitination / Downregulation of ERBB4 signaling / p75NTR recruits signalling complexes / APC-Cdc20 mediated degradation of Nek2A / InlA-mediated entry of Listeria monocytogenes into host cells / protein-RNA complex assembly / Regulation of pyruvate metabolism / TRAF6-mediated induction of TAK1 complex within TLR4 complex / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / Regulation of innate immune responses to cytosolic DNA / NF-kB is activated and signals survival / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / Downregulation of ERBB2:ERBB3 signaling / NRIF signals cell death from the nucleus / Pexophagy / VLDLR internalisation and degradation / maturation of LSU-rRNA / Regulation of PTEN localization / Activated NOTCH1 Transmits Signal to the Nucleus / Regulation of BACH1 activity / MAP3K8 (TPL2)-dependent MAPK1/3 activation / rough endoplasmic reticulum / Translesion synthesis by REV1 / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / InlB-mediated entry of Listeria monocytogenes into host cell / Translesion synthesis by POLK / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / translation regulator activity / Downregulation of TGF-beta receptor signaling
類似検索 - 分子機能
Ribosomal protein L6, N-terminal / Ribosomal protein L6, N-terminal domain / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Ribosomal protein L30e / Ribosomal protein L28e / Ribosomal L15/L27a, N-terminal / Ribosomal protein L13e / Ribosomal protein L23 / Ribosomal protein L2, archaeal-type ...Ribosomal protein L6, N-terminal / Ribosomal protein L6, N-terminal domain / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Ribosomal protein L30e / Ribosomal protein L28e / Ribosomal L15/L27a, N-terminal / Ribosomal protein L13e / Ribosomal protein L23 / Ribosomal protein L2, archaeal-type / Ribosomal protein L30e signature 1. / Ribosomal L28e/Mak16 / Ribosomal L28e protein family / Ribosomal protein L30e signature 2. / Ribosomal protein L30e, conserved site / Ribosomal protein L13e / Ribosomal protein L30/YlxQ / metallochaperone-like domain / TRASH domain / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein L29e / Ribosomal L29e protein family / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein L27e, conserved site / Ribosomal protein L27e signature. / Ribosomal protein L10e, conserved site / Ribosomal protein L10e signature. / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal L38e protein family / Ribosomal protein L10e / Ribosomal protein L44e signature. / Ribosomal protein L24e, conserved site / Ribosomal protein L24e signature. / Ribosomal protein L19/L19e conserved site / Ribosomal protein L19, eukaryotic / Ribosomal protein L19e signature. / : / 60S ribosomal protein L18a/ L20, eukaryotes / Ribosomal protein L6e signature. / : / Ribosomal protein L44e / Ribosomal protein L44 / Ribosomal protein L34e, conserved site / Ribosomal protein L34e signature. / Ribosomal protein L5 eukaryotic, C-terminal / 50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a / Ribosomal L18 C-terminal region / Ribosomal L40e family / Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A / Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A / Ribosomal protein 60S L18 and 50S L18e / Ribosomal_L40e / Ribosomal protein L40e / Ribosomal protein L40e superfamily / Ribosomal protein L18/L18-A/B/e, conserved site / Ribosomal protein L18e signature. / Ribosomal protein L23/L25, N-terminal / : / Ribosomal protein L23, N-terminal domain / Eukaryotic Ribosomal Protein L27, KOW domain / Ribosomal Protein L6, KOW domain / Ribosomal protein L36e signature. / Ribosomal protein L35Ae, conserved site / Ribosomal protein L35Ae signature. / Ribosomal protein L27e / Ribosomal protein L27e superfamily / Ribosomal L27e protein family / Ribosomal protein L39e, conserved site / Ribosomal protein L39e signature. / 60S ribosomal protein L19 / : / Ribosomal protein L13, eukaryotic/archaeal / Ribosomal protein L6e / Ribosomal protein L34Ae / Ribosomal protein L34e / Ribosomal protein L7A/L8 / 60S ribosomal protein L6E / 60S ribosomal protein L35 / Ribosomal protein L18e / Ribosomal protein L19e, C-terminal domain / Ribosomal_L19e / 60S ribosomal protein L4, C-terminal domain / 60S ribosomal protein L4 C-terminal domain / Ribosomal protein L19/L19e / Ribosomal protein L7, eukaryotic / Ribosomal protein L19/L19e, domain 1 / Ribosomal protein L31e, conserved site / Ribosomal protein L19/L19e superfamily / Ribosomal protein L19e, N-terminal domain / Ribosomal protein L31e signature. / Ribosomal protein L30, N-terminal / Ribosomal L30 N-terminal domain / Ribosomal protein L37ae / Ribosomal L37ae protein family / Ribosomal protein L36e / Ribosomal protein L36e domain superfamily
類似検索 - ドメイン・相同性
Large ribosomal subunit protein eL33 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein uL22 / Large ribosomal subunit protein eL13 / Large ribosomal subunit protein uL16 / Large ribosomal subunit protein uL6 / Large ribosomal subunit protein eL22 / Large ribosomal subunit protein uL4 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein uL13 ...Large ribosomal subunit protein eL33 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein uL22 / Large ribosomal subunit protein eL13 / Large ribosomal subunit protein uL16 / Large ribosomal subunit protein uL6 / Large ribosomal subunit protein eL22 / Large ribosomal subunit protein uL4 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein uL13 / Large ribosomal subunit protein uL29 / Large ribosomal subunit protein uL15 / Large ribosomal subunit protein uL18 / Large ribosomal subunit protein eL21 / Large ribosomal subunit protein eL28 / Large ribosomal subunit protein eL29 / Large ribosomal subunit protein eL34 / Large ribosomal subunit protein eL14 / Large ribosomal subunit protein uL24 / Large ribosomal subunit protein eL15 / Large ribosomal subunit protein eL27 / Large ribosomal subunit protein eL43 / Large ribosomal subunit protein eL37 / Large ribosomal subunit protein eL8 / Large ribosomal subunit protein uL23 / Large ribosomal subunit protein uL14 / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein eL31 / Large ribosomal subunit protein eL32 / Large ribosomal subunit protein uL5 / Large ribosomal subunit protein uL2 / Small ribosomal subunit protein eS32 / Ubiquitin-ribosomal protein eL40 fusion protein / Large ribosomal subunit protein eL38 / Large ribosomal subunit protein eL24 / Large ribosomal subunit protein eL42 / Large ribosomal subunit protein eL19 / Large ribosomal subunit protein eL20 / Large ribosomal subunit protein eL6 / Large ribosomal subunit protein eL18 / Large ribosomal subunit protein eL36
類似検索 - 構成要素
生物種Homo sapiens (ヒト) / Human (ヒト)
手法単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.72 Å
データ登録者Takahashi M / Kashiwagi K / Ito T
資金援助 日本, 2件
OrganizationGrant number国
Japan Society for the Promotion of Science (JSPS)JP16H04756 日本
Japan Agency for Medical Research and Development (AMED)JP20gm1410001 日本
引用ジャーナル: Elife / 年: 2022
タイトル: METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance.
著者: Eriko Matsuura-Suzuki / Tadahiro Shimazu / Mari Takahashi / Kaoru Kotoshiba / Takehiro Suzuki / Kazuhiro Kashiwagi / Yoshihiro Sohtome / Mai Akakabe / Mikiko Sodeoka / Naoshi Dohmae / ...著者: Eriko Matsuura-Suzuki / Tadahiro Shimazu / Mari Takahashi / Kaoru Kotoshiba / Takehiro Suzuki / Kazuhiro Kashiwagi / Yoshihiro Sohtome / Mai Akakabe / Mikiko Sodeoka / Naoshi Dohmae / Takuhiro Ito / Yoichi Shinkai / Shintaro Iwasaki /
要旨: Protein methylation occurs predominantly on lysine and arginine residues, but histidine also serves as a methylation substrate. However, a limited number of enzymes responsible for this modification ...Protein methylation occurs predominantly on lysine and arginine residues, but histidine also serves as a methylation substrate. However, a limited number of enzymes responsible for this modification have been reported. Moreover, the biological role of histidine methylation has remained poorly understood to date. Here, we report that human METTL18 is a histidine methyltransferase for the ribosomal protein RPL3 and that the modification specifically slows ribosome traversal on Tyr codons, allowing the proper folding of synthesized proteins. By performing an in vitro methylation assay with a methyl donor analog and quantitative mass spectrometry, we found that His245 of RPL3 is methylated at the τ- position by METTL18. Structural comparison of the modified and unmodified ribosomes showed stoichiometric modification and suggested a role in translation reactions. Indeed, genome-wide ribosome profiling and an in vitro translation assay revealed that translation elongation at Tyr codons was suppressed by RPL3 methylation. Because the slower elongation provides enough time for nascent protein folding, RPL3 methylation protects cells from the cellular aggregation of Tyr-rich proteins. Our results reveal histidine methylation as an example of a ribosome modification that ensures proteome integrity in cells.
履歴
登録2021年6月22日-
ヘッダ(付随情報) 公開2022年6月22日-
マップ公開2022年6月22日-
更新2022年6月22日-
現状2022年6月22日処理サイト: PDBj / 状態: 公開

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構造の表示

添付画像

emd_31465.png

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マップ

ファイルダウンロード / ファイル: emd_31465.map.gz / 形式: CCP4 / 大きさ: 476.8 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
投影像・断面図

画像のコントロール

大きさ
明度
コントラスト
その他
軸X (Sec.)Y (Row.)Z (Col.)
0.97 Å/pix.
x 500 pix.
= 485. Å		0.97 Å/pix.
x 500 pix.
= 485. Å		0.97 Å/pix.
x 500 pix.
= 485. Å

表面

投影像

断面 (1/3)

断面 (1/2)

断面 (2/3)

画像は Spider により作成

ボクセルのサイズX=Y=Z: 0.97 Å
密度

ヒストグラム

ヒストグラム (対数)
表面レベル登録者による: 2.5
最小 - 最大-7.796678 - 32.788944
平均 (標準偏差)1.5573725e-12 (±1.0)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderZYX
Origin000
サイズ500500500
Spacing500500500
セルA=B=C: 485.0 Å
α=β=γ: 90.0 °

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添付データ

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試料の構成要素

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全体 : 60S

全体名称: 60S
要素
  • 複合体: 60S
    • タンパク質・ペプチド: 60S ribosomal protein L8
    • タンパク質・ペプチド: 60S ribosomal protein L3
    • RNA: 28S rRNA
    • RNA: 5S rRNA
    • RNA: 5.8S rRNA
    • タンパク質・ペプチド: 60S ribosomal protein L4
    • タンパク質・ペプチド: 60S ribosomal protein L5
    • タンパク質・ペプチド: 60S ribosomal protein L6
    • タンパク質・ペプチド: 60S ribosomal protein L7
    • タンパク質・ペプチド: 60S ribosomal protein L7a
    • タンパク質・ペプチド: 60S ribosomal protein L9
    • タンパク質・ペプチド: 60S ribosomal protein L10
    • タンパク質・ペプチド: 60S ribosomal protein L11
    • タンパク質・ペプチド: 60S ribosomal protein L13
    • タンパク質・ペプチド: 60S ribosomal protein L14
    • タンパク質・ペプチド: 60S ribosomal protein L15
    • タンパク質・ペプチド: 60S ribosomal protein L13a
    • タンパク質・ペプチド: 60S ribosomal protein L17
    • タンパク質・ペプチド: 60S ribosomal protein L18
    • タンパク質・ペプチド: 60S ribosomal protein L19
    • タンパク質・ペプチド: 60S ribosomal protein L18a
    • タンパク質・ペプチド: 60S ribosomal protein L21
    • タンパク質・ペプチド: 60S ribosomal protein L22
    • タンパク質・ペプチド: 60S ribosomal protein L23
    • タンパク質・ペプチド: 60S ribosomal protein L24
    • タンパク質・ペプチド: 60S ribosomal protein L23a
    • タンパク質・ペプチド: 60S ribosomal protein L26
    • タンパク質・ペプチド: 60S ribosomal protein L27
    • タンパク質・ペプチド: 60S ribosomal protein L27a
    • タンパク質・ペプチド: 60S ribosomal protein L29
    • タンパク質・ペプチド: 60S ribosomal protein L30
    • タンパク質・ペプチド: 60S ribosomal protein L31
    • タンパク質・ペプチド: 60S ribosomal protein L32
    • タンパク質・ペプチド: 60S ribosomal protein L35a
    • タンパク質・ペプチド: 60S ribosomal protein L34
    • タンパク質・ペプチド: 60S ribosomal protein L35
    • タンパク質・ペプチド: 60S ribosomal protein L36
    • タンパク質・ペプチド: 60S ribosomal protein L37
    • タンパク質・ペプチド: 60S ribosomal protein L38
    • タンパク質・ペプチド: 60S ribosomal protein L39
    • タンパク質・ペプチド: Ubiquitin-60S ribosomal protein L40
    • タンパク質・ペプチド: 60S ribosomal protein L41
    • タンパク質・ペプチド: 60S ribosomal protein L36a
    • タンパク質・ペプチド: 60S ribosomal protein L37a
    • タンパク質・ペプチド: 60S ribosomal protein L28
  • リガンド: MAGNESIUM ION
  • リガンド: ZINC ION
  • リガンド: water

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超分子 #1: 60S

超分子名称: 60S / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1-#45
由来(天然)生物種: Homo sapiens (ヒト)

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分子 #1: 60S ribosomal protein L8

分子名称: 60S ribosomal protein L8 / タイプ: protein_or_peptide / ID: 1 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 28.088863 KDa
配列文字列: MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVY CGKKAQLNIG NVLPVGTMPE GTIVCCLEEK PGDRGKLARA SGNYATVISH NPETKKTRVK LPSGSKKVIS S ANRAVVGV ...文字列:
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVY CGKKAQLNIG NVLPVGTMPE GTIVCCLEEK PGDRGKLARA SGNYATVISH NPETKKTRVK LPSGSKKVIS S ANRAVVGV VAGGGRIDKP ILKAGRAYHK YKAKRNCWPR VRGVAMNPVE HPFGGGNHQH IGKPSTIRRD APAGRKVGLI AA RRTGRLR GTKTVQEKEN

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分子 #2: 60S ribosomal protein L3

分子名称: 60S ribosomal protein L3 / タイプ: protein_or_peptide / ID: 2 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 46.211113 KDa
配列文字列: MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGI VGYVETPRGL RTFKTVFAEH ISDECKRRFY KNWHKSKKKA FTKYCKKWQD EDGKKQLEKD FSSMKKYCQV I RVIAHTQM ...文字列:
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGI VGYVETPRGL RTFKTVFAEH ISDECKRRFY KNWHKSKKKA FTKYCKKWQD EDGKKQLEKD FSSMKKYCQV I RVIAHTQM RLLPLRQKKA HLMEIQVNGG TVAEKLDWAR ERLEQQVPVN QVFGQDEMID VIGVTKGKGY KGVTSRWHTK KL PRKTHRG LRKVACIGAW HPARVAFSVA RAGQKGYHHR TEINKKIYKI GQGYLIKDGK LIKNNASTDY DLSDKSINPL GGF VHYGEV TNDFVMLKGC VVGTKKRVLT LRKSLLVQTK RRALEKIDLK FIDTTSKFGH GRFQTMEEKK AFMGPLKKDR IAKE EGA

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分子 #6: 60S ribosomal protein L4

分子名称: 60S ribosomal protein L4 / タイプ: protein_or_peptide / ID: 6 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 47.817641 KDa
配列文字列: MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQ GAFGNMCRGG RMFAPTKTWR RWHRRVNTTQ KRYAICSALA ASALPALVMS KGHRIEEVPE LPLVVEDKVE G YKKTKEAV ...文字列:
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQ GAFGNMCRGG RMFAPTKTWR RWHRRVNTTQ KRYAICSALA ASALPALVMS KGHRIEEVPE LPLVVEDKVE G YKKTKEAV LLLKKLKAWN DIKKVYASQR MRAGKGKMRN RRRIQRRGPC IIYNEDNGII KAFRNIPGIT LLNVSKLNIL KL APGGHVG RFCIWTESAF RKLDELYGTW RKAASLKSNY NLPMHKMINT DLSRILKSPE IQRALRAPRK KIHRRVLKKN PLK NLRIML KLNPYA(MLZ)TMR RNTILRQARN HKLRVDKAAA AAAALQAKSD EKAAVAGKKP VVGKKGKKAA VGVKKQKKPL VGKKAAATK KPAPEKKPAE KKPTTEEKKP AA

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分子 #7: 60S ribosomal protein L5

分子名称: 60S ribosomal protein L5 / タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 34.426789 KDa
配列文字列: MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI ICQIAYARIE GDMIVCAAYA HELPKYGVK VGLTNYAAAY CTGLLLARRL LNRFGMDKIY EGQVEVTGDE YNVESIDGQP GAFTCYLDAG LARTTTGNKV F GALKGAVD ...文字列:
MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI ICQIAYARIE GDMIVCAAYA HELPKYGVK VGLTNYAAAY CTGLLLARRL LNRFGMDKIY EGQVEVTGDE YNVESIDGQP GAFTCYLDAG LARTTTGNKV F GALKGAVD GGLSIPHSTK RFPGYDSESK EFNAEVHRKH IMGQNVADYM RYLMEEDEDA YKKQFSQYIK NSVTPDMMEE MY KKAHAAI RENPVYEKKP KKEVKKKRWN RPKMSLAQKK DRVAQKKASF LRAQERAAES

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分子 #8: 60S ribosomal protein L6

分子名称: 60S ribosomal protein L6 / タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 32.810176 KDa
配列文字列: MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVL ATVTKPVGGD KNGGTRVVKL RKMPRYYPTE DVPRKLLSHG KKPFSQHVRK LRASITPGTI LIILTGRHRG K RVVFLKQL ...文字列:
MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVL ATVTKPVGGD KNGGTRVVKL RKMPRYYPTE DVPRKLLSHG KKPFSQHVRK LRASITPGTI LIILTGRHRG K RVVFLKQL ASGLLLVTGP LVLNRVPLRR THQKFVIATS TKIDISNVKI PKHLTDAYFK KKKLRKPRHQ EGEIFDTEKE KY EITEQRK IDQKAVDSQI LPKIKAIPQL QGYLRSVFAL TNGIYPHKLV F

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分子 #9: 60S ribosomal protein L7

分子名称: 60S ribosomal protein L7 / タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 29.290973 KDa
配列文字列: MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI YEKAKHYHKE YRQMYRTEIR MARMARKAGN FYVPAEPKL AFVIRIRGIN GVSPKVRKVL QLLRLRQIFN GTFVKLNKAS INMLRIVEPY IAWGYPNLKS VNELIYKRGY G KINKKRIA ...文字列:
MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI YEKAKHYHKE YRQMYRTEIR MARMARKAGN FYVPAEPKL AFVIRIRGIN GVSPKVRKVL QLLRLRQIFN GTFVKLNKAS INMLRIVEPY IAWGYPNLKS VNELIYKRGY G KINKKRIA LTDNALIARS LGKYGIICME DLIHEIYTVG KRFKEANNFL WPFKLSSPRG GMKKKTTHFV EGGDAGNRED QI NRLIRRM N

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分子 #10: 60S ribosomal protein L7a

分子名称: 60S ribosomal protein L7a / タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 30.061785 KDa
配列文字列: MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDR QTATQLLKLA HKYRPETKQE KKQRLLARAE KKAAGKGDVP TKRPPVLRAG VNTVTTLVEN KKAQLVVIAH D VDPIELVV ...文字列:
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDR QTATQLLKLA HKYRPETKQE KKQRLLARAE KKAAGKGDVP TKRPPVLRAG VNTVTTLVEN KKAQLVVIAH D VDPIELVV FLPALCRKMG VPYCIIKGKA RLGRLVHRKT CTTVAFTQVN SEDKGALAKL VEAIRTNYND RYDEIRRHWG GN VLGPKSV ARIAKLEKAK AKELATKLG

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分子 #11: 60S ribosomal protein L9

分子名称: 60S ribosomal protein L9 / タイプ: protein_or_peptide / ID: 11 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 21.899471 KDa
配列文字列: MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW WGNRKELATV RTICSHVQNM IKGVTLGFR YKMRSVYAHF PINVVIQENG SLVEIRNFLG EKYIRRVRMR PGVACSVSQA QKDELILEGN DIELVSNSAA L IQQATTVK ...文字列:
MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW WGNRKELATV RTICSHVQNM IKGVTLGFR YKMRSVYAHF PINVVIQENG SLVEIRNFLG EKYIRRVRMR PGVACSVSQA QKDELILEGN DIELVSNSAA L IQQATTVK NKDIRKFLDG IYVSEKGTVQ QADE

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分子 #12: 60S ribosomal protein L10

分子名称: 60S ribosomal protein L10 / タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 24.657084 KDa
配列文字列: MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL SSEALEAARI CANKYMVKSC GKDGFHIRV RLHPFHVIRI NKMLSCAGAD RLQTGMRGAF GKPQGTVARV HIGQVIMSIR TKLQNKEHVI EALRRAKFKF P GRQKIHIS ...文字列:
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL SSEALEAARI CANKYMVKSC GKDGFHIRV RLHPFHVIRI NKMLSCAGAD RLQTGMRGAF GKPQGTVARV HIGQVIMSIR TKLQNKEHVI EALRRAKFKF P GRQKIHIS KKWGFTKFNA DEFEDMVAEK RLIPDGCGVK YIPNRGPLDK WRALHS

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分子 #13: 60S ribosomal protein L11

分子名称: 60S ribosomal protein L11 / タイプ: protein_or_peptide / ID: 13 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 20.288465 KDa
配列文字列:
MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKV REYELRKNNF SDTGNFGFGI QEHIDLGIKY DPSIGIYGLD FYVVLGRPGF SIADKKRRTG CIGAKHRISK E EAMRWFQQ KYDGIILPGK

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分子 #14: 60S ribosomal protein L13

分子名称: 60S ribosomal protein L13 / タイプ: protein_or_peptide / ID: 14 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 24.321682 KDa
配列文字列: MAPSRNGMVL KPHFHKDWQR RVATWFNQPA RKIRRRKARQ AKARRIAPRP ASGPIRPIVR CPTVRYHTKV RAGRGFSLEE LRVAGIHKK VARTIGISVD PRRRNKSTES LQANVQRLKE YRSKLILFPR KPSAPKKGDS SAEELKLATQ LTGPVMPVRN V YKKEKARV ...文字列:
MAPSRNGMVL KPHFHKDWQR RVATWFNQPA RKIRRRKARQ AKARRIAPRP ASGPIRPIVR CPTVRYHTKV RAGRGFSLEE LRVAGIHKK VARTIGISVD PRRRNKSTES LQANVQRLKE YRSKLILFPR KPSAPKKGDS SAEELKLATQ LTGPVMPVRN V YKKEKARV ITEEEKNFKA FASLRMARAN ARLFGIRAKR AKEAAEQDVE KKK

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分子 #15: 60S ribosomal protein L14

分子名称: 60S ribosomal protein L14 / タイプ: protein_or_peptide / ID: 15 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 23.485016 KDa
配列文字列: MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM PFKCMQLTDF ILKFPHSAHQ KYVRQAWQKA DINTKWAAT RWAKKIEARE RKAKMTDFDR FKVMKAKKMR NRIIKNEVKK LQKAALLKAS PKKAPGTKGT AAAAAAAAAA K VPAKKITA ...文字列:
MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM PFKCMQLTDF ILKFPHSAHQ KYVRQAWQKA DINTKWAAT RWAKKIEARE RKAKMTDFDR FKVMKAKKMR NRIIKNEVKK LQKAALLKAS PKKAPGTKGT AAAAAAAAAA K VPAKKITA ASKKAPAQKV PAQKATGQKA APAPKAQKGQ KAPAQKAPAP KASGKKA

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分子 #16: 60S ribosomal protein L15

分子名称: 60S ribosomal protein L15 / タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 24.207285 KDa
配列文字列: MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR LGYKAKQGYV IYRIRVRRGG RKRPVPKGAT YGKPVHHGV NQLKFARSLQ SVAEERAGRH CGALRVLNSY WVGEDSTYKF FEVILIDPFH KAIRRNPDTQ WITKPVHKHR E MRGLTSAG ...文字列:
MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR LGYKAKQGYV IYRIRVRRGG RKRPVPKGAT YGKPVHHGV NQLKFARSLQ SVAEERAGRH CGALRVLNSY WVGEDSTYKF FEVILIDPFH KAIRRNPDTQ WITKPVHKHR E MRGLTSAG RKSRGLGKGH KFHHTIGGSR RAAWRRRNTL QLHRYR

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分子 #17: 60S ribosomal protein L13a

分子名称: 60S ribosomal protein L13a / タイプ: protein_or_peptide / ID: 17 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 23.633412 KDa
配列文字列: MAEVQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLP HKTKRGQAAL DRLKVFDGIP PPYDKKKRMV VPAALKVVRL KPTRKFAYLG RLAHEVGWKY QAVTATLEEK R KEKAKIHY ...文字列:
MAEVQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLP HKTKRGQAAL DRLKVFDGIP PPYDKKKRMV VPAALKVVRL KPTRKFAYLG RLAHEVGWKY QAVTATLEEK R KEKAKIHY RKKKQLMRLR KQAEKNVEKK IDKYTEVLKT HGLLV

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分子 #18: 60S ribosomal protein L17

分子名称: 60S ribosomal protein L17 / タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 21.44317 KDa
配列文字列:
MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD VTLQKQCVPF RRYNGGVGRC AQAKQWGWTQ GRWPKKSAE FLLHMLKNAE SNAELKGLDV DSLVIEHIQV NKAPKMRRRT YRAHGRINPY MSSPCHIEMI LTEKEQIVPK P EEEVAQKK KISQKKLKKQ KLMARE

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分子 #19: 60S ribosomal protein L18

分子名称: 60S ribosomal protein L18 / タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 21.687676 KDa
配列文字列:
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP LSLSRMIRKM KLPGRENKTA VVVGTITDD VRVQEVPKLK VCALRVTSRA RSRILRAGGK ILTFDQLALD SPKGCGTVLL SGPRKGREVY RHFGKAPGTP H SHTKPYVR SKGRKFERAR GRRASRGYKN

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分子 #20: 60S ribosomal protein L19

分子名称: 60S ribosomal protein L19 / タイプ: protein_or_peptide / ID: 20 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 23.535281 KDa
配列文字列: MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARM PEKVTWMRRM RILRRLLRRY RESKKIDRHM YHSLYLKVKG NVFKNKRILM EHIHKLKADK ARKKLLADQA E ARRSKTKE ...文字列:
MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARM PEKVTWMRRM RILRRLLRRY RESKKIDRHM YHSLYLKVKG NVFKNKRILM EHIHKLKADK ARKKLLADQA E ARRSKTKE ARKRREERLQ AKKEEIIKTL SKEEETKK

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分子 #21: 60S ribosomal protein L18a

分子名称: 60S ribosomal protein L18a / タイプ: protein_or_peptide / ID: 21 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 20.808514 KDa
配列文字列:
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSG THNMYREYRD LTTAGAVTQC YRDMGARHRA RAHSIQIMKV EEIAASKCRR PAVKQFHDSK IKFPLPHRVL R RQHKPRFT TKRPNTFF

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分子 #22: 60S ribosomal protein L21

分子名称: 60S ribosomal protein L21 / タイプ: protein_or_peptide / ID: 22 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 18.609988 KDa
配列文字列:
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK GMPHKCYHGK TGRVYNVTQH AVGIVVNKQV KGKILAKRI NVRIEHIKHS KSRDSFLKRV KENDQKKKEA KEKGTWVQLK RQPAPPREAH FVRTNGKEPE LLEPIPYEFM A

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分子 #23: 60S ribosomal protein L22

分子名称: 60S ribosomal protein L22 / タイプ: protein_or_peptide / ID: 23 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 14.813015 KDa
配列文字列:
MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV VTIERSKSKI TVTSEVPFSK RYLKYLTKK YLKKNNLRDW LRVVANSKES YELRYFQINQ DEEEEEDED

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分子 #24: 60S ribosomal protein L23

分子名称: 60S ribosomal protein L23 / タイプ: protein_or_peptide / ID: 24 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 14.892505 KDa
配列文字列:
MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM VMATVKKGKP ELRKKVHPAV VIRQRKSYR RKDGVFLYFE DNAGVIVNNK GEMKGSAITG PVAKECADLW PRIASNAGSI A

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分子 #25: 60S ribosomal protein L24

分子名称: 60S ribosomal protein L24 / タイプ: protein_or_peptide / ID: 25 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 17.825111 KDa
配列文字列:
MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN WTVLYRRKHK KGQSEEIQKK RTRRAVKFQR AITGASLAD IMAKRNQKPE VRKAQREQAI RAAKEAKKAK QASKKTAMAA AKAPTKAAPK QKIVKPVKVS APRVGGKR

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分子 #26: 60S ribosomal protein L23a

分子名称: 60S ribosomal protein L23a / タイプ: protein_or_peptide / ID: 26 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 17.740193 KDa
配列文字列:
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKK IEDNNTLVFI VDVKANKHQI KQAVKKLYDI DVAKVNTLIR PDGEKKAYVR LAPDYDALDV ANKIGII

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分子 #27: 60S ribosomal protein L26

分子名称: 60S ribosomal protein L26 / タイプ: protein_or_peptide / ID: 27 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 17.303363 KDa
配列文字列:
MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREK ANGTTVHVGI HPSKVVITRL KLDKDRKKIL ERKAKSRQVG KEKGKYKEET IEKMQE

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分子 #28: 60S ribosomal protein L27

分子名称: 60S ribosomal protein L27 / タイプ: protein_or_peptide / ID: 28 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 15.835831 KDa
配列文字列:
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDI PLDKTVVNKD VFRDPALKRK ARREAKVKFE ERYKTGKNKW FFQKLRF

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分子 #29: 60S ribosomal protein L27a

分子名称: 60S ribosomal protein L27a / タイプ: protein_or_peptide / ID: 29 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 16.604535 KDa
配列文字列:
MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH YHLKRNQSFC PTVNLDKLWT LVSEQTRVN AAKNKTGAAP IIDVVRSGYY KVLGKGKLPK QPVIVKAKFF SRRAEEKIKS VGGACVLVA

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分子 #30: 60S ribosomal protein L29

分子名称: 60S ribosomal protein L29 / タイプ: protein_or_peptide / ID: 30 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 17.804275 KDa
配列文字列:
MAKSKNHTTH NQSRKWHRNG IKKPRSQRYE SLKGVDPKFL RNMRFAKKHN KKGLKKMQAN NAKAMSARAE AIKALVKPKE VKPKIPKGV SRKLDRLAYI AHPKLGKRAR ARIAKGLRLC RPKAKAKAKA KDQTKAQAAA PASVPAQAPK RTQAPTKASE

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分子 #31: 60S ribosomal protein L30

分子名称: 60S ribosomal protein L30 / タイプ: protein_or_peptide / ID: 31 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 12.805092 KDa
配列文字列:
MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN NCPALRKSEI EYYAMLAKTG VHHYSGNNIE LGTACGKYY RVCTLAIIDP GDSDIIRSMP EQTGEK

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分子 #32: 60S ribosomal protein L31

分子名称: 60S ribosomal protein L31 / タイプ: protein_or_peptide / ID: 32 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 14.494938 KDa
配列文字列:
MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP DVRIDTRLNK AVWAKGIRNV PYRIRVRLS RKRNEDEDSP NKLYTLVTYV PVTTFKNLQT VNVDEN

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分子 #33: 60S ribosomal protein L32

分子名称: 60S ribosomal protein L32 / タイプ: protein_or_peptide / ID: 33 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 15.898932 KDa
配列文字列:
MAALRPLVKP KIVKKRTKKF IRHQSDRYVK IKRNWRKPRG IDNRVRRRFK GQILMPNIGY GSNKKTKHML PSGFRKFLVH NVKELEVLL MCNKSYCAEI AHNVSSKNRK AIVERAAQLA IRVTNPNARL RSEENE

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分子 #34: 60S ribosomal protein L35a

分子名称: 60S ribosomal protein L35a / タイプ: protein_or_peptide / ID: 34 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 12.564743 KDa
配列文字列:
MSGRLWSKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV YKAKNNTVTP GGKPNKTRVI WGKVTRAHGN SGMVRAKFR SNLPAKAIGH RIRVMLYPSR I

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分子 #35: 60S ribosomal protein L34

分子名称: 60S ribosomal protein L34 / タイプ: protein_or_peptide / ID: 35 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 13.326074 KDa
配列文字列:
MVQRLTYRRR LSYNTASNKT RLSRTPGNRI VYLYTKKVGK APKSACGVCP GRLRGVRAVR PKVLMRLSKT KKHVSRAYGG SMCAKCVRD RIKRAFLIEE QKIVVKVLKA QAQSQKAK

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分子 #36: 60S ribosomal protein L35

分子名称: 60S ribosomal protein L35 / タイプ: protein_or_peptide / ID: 36 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 14.593624 KDa
配列文字列:
MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV RKSIARVLTV INQTQKENLR KFYKGKKYKP LDLRPKKTR AMRRRLNKHE ENLKTKKQQR KERLYPLRKY AVKA

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分子 #37: 60S ribosomal protein L36

分子名称: 60S ribosomal protein L36 / タイプ: protein_or_peptide / ID: 37 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 12.290859 KDa
配列文字列:
MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF APYERRAMEL LKVSKDKRAL KFIKKRVGTH IRAKRKREE LSNVLAAMRK AAAKKD

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分子 #38: 60S ribosomal protein L37

分子名称: 60S ribosomal protein L37 / タイプ: protein_or_peptide / ID: 38 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 11.111032 KDa
配列文字列:
MTKGTSSFGK RRNKTHTLCR RCGSKAYHLQ KSTCGKCGYP AKRKRKYNWS AKAKRRNTTG TGRMRHLKIV YRRFRHGFRE GTTPKPKRA AVAASSSS

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分子 #39: 60S ribosomal protein L38

分子名称: 60S ribosomal protein L38 / タイプ: protein_or_peptide / ID: 39 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 8.238948 KDa
配列文字列:
MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL PPGLAVKELK

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分子 #40: 60S ribosomal protein L39

分子名称: 60S ribosomal protein L39 / タイプ: protein_or_peptide / ID: 40 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 6.426759 KDa
配列文字列:
MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG L

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分子 #41: Ubiquitin-60S ribosomal protein L40

分子名称: Ubiquitin-60S ribosomal protein L40 / タイプ: protein_or_peptide / ID: 41 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 14.771411 KDa
配列文字列:
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGIIEP SLRQLAQKY NCDKMICR(MLZ)C YARLHPRAVN CRKKKCGHTN NLRPKKKVK

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分子 #42: 60S ribosomal protein L41

分子名称: 60S ribosomal protein L41 / タイプ: protein_or_peptide / ID: 42 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 3.473451 KDa
配列文字列:
MRAKWRKKRM RRLKRKRRKM RQRSK

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分子 #43: 60S ribosomal protein L36a

分子名称: 60S ribosomal protein L36a / タイプ: protein_or_peptide / ID: 43 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 12.476973 KDa
配列文字列:
MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGKRR YDRKQSGYGG QTKPIFRKKA KTTKKIVLRL ECVEPNCRSK RMLAIKRCK HFELGGDKKR KGQVIQF

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分子 #44: 60S ribosomal protein L37a

分子名称: 60S ribosomal protein L37a / タイプ: protein_or_peptide / ID: 44 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 10.29935 KDa
配列文字列:
MAKRTKKVGI VGKYGTRYGA SLRKMVKKIE ISQHAKYTCS FCGKTKMKRR AVGIWHCGSC MKTVAGGAWT YNTTSAVTVK SAIRRLKEL KDQ

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分子 #45: 60S ribosomal protein L28

分子名称: 60S ribosomal protein L28 / タイプ: protein_or_peptide / ID: 45 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Human (ヒト)
分子量理論値: 15.784622 KDa
配列文字列:
MSAHLQWMVV RNCSSFLIKR NKQTYSTEPN NLKARNSFRY NGLIHRKTVG VEPAADGKGV VVVIKRRSGQ RKPATSYVRT TINKNARAT LSSIRHMIRK NKYRPDLRMA AIRRASAILR SQKPVMVKRK RTRPTKSS

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分子 #3: 28S rRNA

分子名称: 28S rRNA / タイプ: rna / ID: 3 / コピー数: 1
由来(天然)生物種: Human (ヒト)
分子量理論値: 1.641428125 MDa
配列文字列: CGCGACCUCA GAUCAGACGU GGCGACCCGC UGAAUUUAAG CAUAUUAGUC AGCGGAGGAG AAGAAACUAA CCAGGAUUCC CUCAGUAAC GGCGAGUGAA CAGGGAAGAG CCCAGCGCCG AAUCCCCGCC CCGCGGCGGG GCGCGGGACA UGUGGCGUAC G GAAGACCC ...文字列:
CGCGACCUCA GAUCAGACGU GGCGACCCGC UGAAUUUAAG CAUAUUAGUC AGCGGAGGAG AAGAAACUAA CCAGGAUUCC CUCAGUAAC GGCGAGUGAA CAGGGAAGAG CCCAGCGCCG AAUCCCCGCC CCGCGGCGGG GCGCGGGACA UGUGGCGUAC G GAAGACCC GCUCCCCGGC GCCGCUCGUG GGGGGCCCAA GUCCUUCUGA UCGAGGCCCA GCCCGUGGAC GGUGUGAGGC CG GUAGCGG CCCCCGGCGC GCCGGGCCCG GGUCUUCCCG GAGUCGGGUU GCUUGGGAAU GCAGCCCAAA GCGGGUGGUA AAC UCCAUC UAAGGCUAAA UACCGGCACG AGACCGAUAG UCAACAAGUA CCGUAA(OMG)GGA AAGUUGAAAA GAACUUUGAA G(A2M)G(A2M)GAGUU CAAGAGGGCG UGAAACCGUU AAGAGGUAAA CGGGUGGGGU CCGCGCAGUC CGCCCGGAGG AUU CAACCC GGCGGCGGGU CCGGCCGUGU CGGCGGCCCG GCGGAUCUUU CCCGCCCCCC GUUCCUCCCG ACCCCUCCAC CCGC CCUCC CUUCCCCCGC CGCCCCUCCU CCUCCUCCCC GGAGGGGGCG GGCUCCGGCG GGUGCGGGGG UGGGCGGGCG GGGCC GGGG GUGGGGUCGG CGGGGGACCG UCCCCCGACC GGCGACCGGC CGCCGCCGGG CGCAUUUCCA CCGCGGCGGU GCGCCG CGA CCGGCUCCGG GACGGCU(2MG)GG AAGGCCCGGC GGGGAAGGUG GCUCGGGGGG CCCCGUCCGU CCGUCCGUCC GUC CUCCUC CUCCCCCGUC UCCGCCCCCC GGCCCCGCGU CCUCCCUCGG GAGGGCGCGC GGGUCGGGGC GGCGGCGGCG GCGG CGGUG GCGGCGGCGG CGGCGGCGGC GGGACCGAAA CCCCCCCCGA GUGUUACAGC CCCCCCGGCA GCAGCACUCG CCGAA UCCC GGGGCCGAGG GAGCGAGACC CGUCGCCGC(2MG) CUCUCCCCCC UCCCGGCGCC CACCCCCGCG GGGAAUCCCC CG CGAGGGG GGUCUCCCCC GCGGGGGCGC GCCGGCGUCU CCUCGUGGGG GGGCCGGGCC ACCCCUCCCA CGGCGCGACC GCU CUCCCA CCCCUCCUCC CCGCGCCCCC GCCCCGGCGA CGGGGGGGGU GCCGCGCGCG GGUCGGGGGG CGGGGCGGAC UGUC CCCAG UGCGCCCCGG GCGGGUCGCG CCGUCGGGCC CGGGGGAGGU UCUCUCGGGG CCACGCGCGC GUCCCCCGAA GAGGG GGAC GGCGGAGCGA GCGCACGGGG UCGGCGGCGA CGUCGGCUAC CCACCCGACC C(OMG)UCUUG(1MA)(A2M)A C (A2M)CGGACCA AGGAGU(OMC)UAA CACGUGCGCG AGUCGGGGGC UCGCACGAAA GCCGCCGUGG CGCAAUGAAG GUGA AGGCC GGCGCGCUCG CCGGCCGAGG UGGGAUCCCG AGGCCUCUCC AGUCCGCCGA GGG(JMH)GCACCA CCGGCCCGUC U CGCCCGCC GCGCCGGGGA GGUGGAGCAC GAGCGCACGU GUUAG(2MG)ACCC (OMG)A(A2M)AGAUGGU GA(A2M)C (PSU)AUGC CUGGGCAGGG CGAAGCCAGA GGAAACUCUG GUGGAGGUCC G(PSU)AGCGGUCC UGACGUGCAA AUCGGUC GU CCGACCUGGG UAUAG(OMG)GGCG AAAGACUAAU CGAACCAUCU AGUAGCUGGU UCCCUCCGAA GUUUCCC(PSU)CA GGA(PSU)AGCUG GCGCUCUCGC AGACCCGACG CACCCCCGCC ACGCAGUUUU AUCCGGUAAA GCGAA(PSU)GAUU AGA GGUCUU GGGGCCGAAA CGAUCUCAAC C(PSU)A(PSU)(PSU)CUCAA ACUU(PSU)AAAUG GGUAAGAAGC CCGGCUCG C UGGCGUGGAG CCGGGCGUGG AAUGCGAGUG CCUAGUGGGC CAC(PSU)U(PSU)UGG(UR3) AAGC(A2M)GAACU GGC GCU(OMG)CG GGAUGAACCG AACGCCGGGU UAAGGCGCCC GAUGCCGACG CUCAUCAGAC CCCAGAAAAG GUGUUGGUUG AUAUAGACA GCAGGACGGU GGCCAUGGAA GUCGGAAUCC GCUAAGGAGU GUGUAACAAC UCACCUGCCG AAUCAACUAG C CCUGAAAA UGGAUG(OMG)CGC UGGAGCGUCG GGCCCAUACC CGGCCGUCGC CGGCAGUCGA GAGUGGACGG GAGCGGCG G GGGCGGCGCG CGCGCGCGCG CGUGUGGUGU GCGUCGGAGG GCGGCGGCGG CGGCGGCGGC GGGGGUGUGG GGUCCUUCC CCCGCCCCCC CCCCCACGCC UCCUCCCCUC CUCCCGCCCA CGCCCCGCUC CCCGCCCCCG GAGCCCCGCG GACGCUACGC CGCGACGAG UAGGAGGGCC GCUGCGGUGA GCCUUGAAGC CUAGGGCGCG GGCCCGGGUG GAGCCGCCGC AGGUGCAGAU (OMC)UUGGUGGU AGU(A2M)(OMG)(OMC)AAAU AUUCAAACGA GAACUUUGAA GGCCGAAGUG G(A2M)GAAGGGUU C CAUG(OMU)GAA CAG(OMC)A(OMG)UUGA ACAUGGGUCA GUCGGUCCUG AGAGAUGGGC GAGCGCCGUU CCGAAGGGAC GGGCGAUGG CCUCCGUUGC CCUCGGCCGA (PSU)CGAAAGGGA GUCGGGUUCA GAUCCCCGAA UCCGGAGUGG CGGAGAU GG GCGCCGCGAG GCGUCCAGUG CGGUAACGCG ACCGAUCCCG GAGAAGCCGG CGGGAGCCCC GGGGAGAGUU CUCUU (PSU)UCU UUGUGAAGGG CAGGGCGCCC UGGAAUGGGU UCGCCCCGAG AGAGGGGCCC GUGCCUUGGA AAGCGUCGCG GU UCCGGCG GCGUCCGGUG AGCUCUCGCU GGCCCUUGAA AAUCCGGGGG AGAGGGUGUA AAUCUCGC(OMG)C CGGGCCGUA CCC(A2M)UAUCCG CAGCAGGUCU (OMC)CAAGGUGAA C(A2M)GCCUCUGG (OMC)AUGUUGGAA CAA(OMU)G(PSU) AGG (PSU)AAGGGAAGU CGGCAAGC(OMC)G GAUCCGUAAC UUC(OMG)GGAUAA GGAUUGGCUC UAAGGGCUGG GUCGG UCGG GCUGGGGCGC GAAGCGGGGC UGGGCGCGCG CCGCGGCUGG ACGAGGCGCC GCCGCCCCCC CCACGCCCGG GGCACC CCC CUCGCGGCCC UCCCCCGCCC CACCCCGCGC GCGCCGCUCG CUCCCUCCCC GCCCCGCGCC CUCUCUCUCU CUCUCUC CC CCGCUCCCCG UCCUCCCCCC UCCCCGGGGG AGCGCCGCGU GGGGGCGGCG GCGGGGGGAG AAGGGUCGGG GCGGCAGG G GCCGGCGGCG GCCCGCCGCG GGGCCCCGGC GGCGGGGGCA CGGUCCCCCG CGAGGGGGGC CCGGGCACCC GGGGGGCCG GCGGCGGCGG CGACUCUGGA CGCGAGCCGG GCCCUUCCCG UGGAUCGCCC CAGCUGCGGC GGGCGUCGCG GCCGCCCCCG GGGAGCCCG GCGGGCGCCG GCGCGCCCCC CCCCCCACCC CACGUCUCGU CGCGCGCGCG UCCGCUGGGG GCGGGGAGCG G UCGGGCGG CGGCGGUCGG CGGGCGGCGG GGCGGGGCGG UUCGUCCCCC CGCCCUACCC CCCCGGCCCC GUCCGCCCCC CG UUCCCCC CUCCUCCUCG GCGCGCGGCG GCGGCGGCGG CAGGCGGCGG AGGGGCCGCG GGCCGGUCCC CCCCGCCGGG UCC GCCCCC GGGGCCGCGG UUCCGCGCGG CGCCUCGCCU CGGCCGGCGC CUAGCAGCCG ACUUAGAACU GGUGCGGACC AGG (OMG)GAAUC CGAC(PSU)G(PSU)UUA AUUAAAACAA AGCAUCGCGA AGGCCCGCGG CGGGUGUUGA CGCGAUGUGA UU (PSU)CUGCC(OMC) AGUGCUCUGA AUG(PSU)CA(A2M)AGU G(A2M)AGAAAU(PSU)C AA(PSU)GAAGCGC GG (OMG)UAAACG GCGGGAG(PSU)AA C(PSU)A(PSU)GAC(PSU)C(PSU) CUUAAGGUAG C(5MC)AA(A2M)UGCCU C (OMG)UCAUCUA AUUAGUGA(OMC)G CGCAUGAA(UY1)G GA(PSU)GA(A2M)CGAG (A2M)UUCCCACUG U(OMC)CC UACCU ACUAUCCAGC GAAACCAC(A2M)G (OMC)CAAGGGAAC GGGCUUGG(OMC)G GAAUCAGCGG (OMG)GAAAGAAG A(OMC)CCUGUUGA GC(PSU)UGAC(OMU)CU AGUCUGGCAC GGUGAA(OMG)AGA CAUGAGAGGU GUAGAAUAAG UGGG AGGCC CCCGGCGCCC CCCCGGUGUC CCCGCGAGGG GCCCGGGGCG GGGUCCGCCG GCCCUGCGGG CCGCCGGUGA AAUAC CACU ACUCUGAUCG UUUUUUCACU GACCCGG(5MU)GA GGCGGGGGGG CGAGCCCCGA GGGGCUCUCG CUUCUGGCGC CA AGCGCCC GGCCGCGCGC CGGCCGGGCG CGACCCGCUC CGGGGACAGU GCCAGGUGGG GA(OMG)UUUGACU G(OMG)GGC GGUA CACCUGUCAA ACGGUA(6MZ)CGC AGG(OMU)(OMG)UCCUA AGGCGAGCUC AGGGAGGACA GAAACCUCCC GUGG AGCAG AAGGGCAAAA GCUCGCUUGA (PSU)CU(PSU)GA(PSU)UUU CAG(OMU)ACGAA(PSU) ACAGACCGUG AAAGC GGGG CCU(5MC)ACGAUC CUUCUGACCU U(PSU)UGGGUUU(PSU) AAGCAGGA(OMG)G UGUCAGAAAA GUUACCACAG (OMG)GAUAACUG GC(PSU)UGUGGCG GCCA(1MA)GCGU(PSU) CA(PSU)AGCGACG (PSU)CGCUUUUUG A(PSU)C CUU(5MC)GA (PSU)GUCGG(OMC)(PSU)CU UCCUAUCAUU G(PSU)GAAGCAGA AUU(B8T)ACCAAG CGU(PSU) (OMG)GAU(OMU) (OMG)(PSU)UCACCCAC UAAUAGGGAA CG(PSU)G(A2M)GCUGG G(UR3)(PSU)(PSU)AGA (OMC)C GUCGUGAGAC AGGU(PSU)AGUUU UACCCUACUG AUG(A2M)UGUG(PSU)U G(PSU)UGCCAUGG UA(A2M)U CCUGC (UR3)CAGUACGAG AGGAACCGCA G(OMG)U(OMU)CA(OMG)ACA U(PSU)UGGUGUA(PSU) (OMG)UGCUUG GC UGAGGAGCCA AUGGGGCGAA GCUAC(B8T)A(PSU)CU GUGGGAUUAU GAC(PSU)GAACGC CUCUAAGUCA GAAUCC CGC CCAGGCGGAA CGAUACGGCA GCGCCGCGGA GCCUCGGUUG GCCUCGGAUA GCCGGUCCCC CGCCUGUCCC CGCCGGC GG GCCGCCCCCC CCCUCCACGC GCCCCGCGCG CGCGGGAGGG CGCGUGCCCC GCCGCGCGCC GGGACCGGGG UCCGGU (OMG)C(2MG) GAGUGCCCUU CGUCCUGGGA AACGGGGCGC GGCCGGAGAG GCGGCCGCCC CCUCGCCCGU CACGCACCG CACGUUCGUG GGGAACCUGG CGCUAAACCA UUCGUAGACG ACCUGCUUCU GGGUCGGGGU UUCGUACGUA GCAGAGCAGC UCCCUCGCU GCGAUCUAUU GAAAGUCAGC CCUCGACACA AGGGUUUGUC

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分子 #4: 5S rRNA

分子名称: 5S rRNA / タイプ: rna / ID: 4 / コピー数: 1
由来(天然)生物種: Human (ヒト)
分子量理論値: 38.691914 KDa
配列文字列:
GUCUACGGCC AUACCACCCU GAACGCGCCC GAUCUCGUCU GAUCUCGGAA GCUAAGCAGG GUCGGGCCUG GUUAGUACUU GGAUGGGAG ACCGCCUGGG AAUACCGGGU GCUGUAGGCU U

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分子 #5: 5.8S rRNA

分子名称: 5.8S rRNA / タイプ: rna / ID: 5 / コピー数: 1
由来(天然)生物種: Human (ヒト)
分子量理論値: 50.157676 KDa
配列文字列:
CGACUCUUAG CGG(OMU)GGAUCA CUCGGCUCGU GCGUCGAUGA AGAACGCAGC UAGCUGCGAG AAUUAAUGUG AAUUGC AGG ACACAUUGAU CAUCGACACU UCGAACGCAC UUGCGGCCCC GGGUUCCUCC CGGGGCUACG CCUGUCUGAG CGUCGCU

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分子 #46: MAGNESIUM ION

分子名称: MAGNESIUM ION / タイプ: ligand / ID: 46 / コピー数: 279 / 式: MG
分子量理論値: 24.305 Da

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分子 #47: ZINC ION

分子名称: ZINC ION / タイプ: ligand / ID: 47 / コピー数: 5 / 式: ZN
分子量理論値: 65.409 Da

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分子 #48: water

分子名称: water / タイプ: ligand / ID: 48 / コピー数: 18 / 式: HOH
分子量理論値: 18.015 Da
Chemical component information

ChemComp-HOH:
WATER

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析単粒子再構成法
試料の集合状態particle

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試料調製

緩衝液pH: 7.5
凍結凍結剤: ETHANE

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電子顕微鏡法

顕微鏡FEI TECNAI ARCTICA
撮影フィルム・検出器のモデル: GATAN K2 SUMMIT (4k x 4k)
平均電子線量: 50.0 e/Å2
電子線加速電圧: 200 kV / 電子線源: FIELD EMISSION GUN
電子光学系照射モード: FLOOD BEAM / 撮影モード: BRIGHT FIELD
実験機器
モデル: Talos Arctica / 画像提供: FEI Company

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画像解析

最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 2.72 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 118470
初期 角度割当タイプ: MAXIMUM LIKELIHOOD
最終 角度割当タイプ: MAXIMUM LIKELIHOOD

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

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