- EMDB-27233: Tomogram of Flublok vaccine hemagglutinin starfish complexes -
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基本情報
登録情報
データベース: EMDB / ID: EMD-27233
タイトル
Tomogram of Flublok vaccine hemagglutinin starfish complexes
マップデータ
tomogram of Flublok hemagglutinin "starfish" particles.
試料
複合体: Expressed hemagglutinin protein from these influenza viruses: A/Michigan/45/2015 A/Singapore/INFIMH-16-0019/2016 B/Maryland/15/2016 B/Phuket/3073/2013
複合体: A/Michigan/45/2015 hemagglutinin protein
複合体: A/Singapore/INFIMH-16-0019/2016 hemagglutinin protein
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
1ZIAAI001180
米国
引用
ジャーナル: Nat Commun / 年: 2023 タイトル: Commercial influenza vaccines vary in HA-complex structure and in induction of cross-reactive HA antibodies. 著者: Mallory L Myers / John R Gallagher / Alexander J Kim / Walker H Payne / Samantha Maldonado-Puga / Haralabos Assimakopoulos / Kevin W Bock / Udana Torian / Ian N Moore / Audray K Harris / 要旨: Influenza virus infects millions of people annually and can cause global pandemics. Hemagglutinin (HA) is the primary component of commercial influenza vaccines (CIV), and antibody titer to HA is a ...Influenza virus infects millions of people annually and can cause global pandemics. Hemagglutinin (HA) is the primary component of commercial influenza vaccines (CIV), and antibody titer to HA is a primary correlate of protection. Continual antigenic variation of HA requires that CIVs are reformulated yearly. Structural organization of HA complexes have not previously been correlated with induction of broadly reactive antibodies, yet CIV formulations vary in how HA is organized. Using electron microscopy to study four current CIVs, we find structures including: individual HAs, starfish structures with up to 12 HA molecules, and novel spiked-nanodisc structures that display over 50 HA molecules along the complex's perimeter. CIV containing these spiked nanodiscs elicit the highest levels of heterosubtypic cross-reactive antibodies in female mice. Here, we report that HA structural organization can be an important CIV parameter and can be associated with the induction of cross-reactive antibodies to conserved HA epitopes.
全体 : Expressed hemagglutinin protein from these influenza viruses: A/M...
全体
名称: Expressed hemagglutinin protein from these influenza viruses: A/Michigan/45/2015 A/Singapore/INFIMH-16-0019/2016 B/Maryland/15/2016 B/Phuket/3073/2013
要素
複合体: Expressed hemagglutinin protein from these influenza viruses: A/Michigan/45/2015 A/Singapore/INFIMH-16-0019/2016 B/Maryland/15/2016 B/Phuket/3073/2013
複合体: A/Michigan/45/2015 hemagglutinin protein
複合体: A/Singapore/INFIMH-16-0019/2016 hemagglutinin protein
複合体: B/Maryland/15/2016 hemagglutinin protein
複合体: B/Phuket/3073/2013 hemagglutinin protein
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超分子 #1: Expressed hemagglutinin protein from these influenza viruses: A/M...
超分子
名称: Expressed hemagglutinin protein from these influenza viruses: A/Michigan/45/2015 A/Singapore/INFIMH-16-0019/2016 B/Maryland/15/2016 B/Phuket/3073/2013 タイプ: complex / ID: 1 / キメラ: Yes / 親要素: 0