National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
1R35GM138301
United States
Welch Foundation
AU-1953-20180324
United States
Citation
Journal: Proc Natl Acad Sci U S A / Year: 2022 Title: A unique bacterial secretion machinery with multiple secretion centers. Authors: Liqiang Song / John D Perpich / Chenggang Wu / Thierry Doan / Zuzanna Nowakowska / Jan Potempa / Peter J Christie / Eric Cascales / Richard J Lamont / Bo Hu / Abstract: The Porphyromonas gingivalis type IX secretion system (T9SS) promotes periodontal disease by secreting gingipains and other virulence factors. By in situ cryoelectron tomography, we report that the P. ...The Porphyromonas gingivalis type IX secretion system (T9SS) promotes periodontal disease by secreting gingipains and other virulence factors. By in situ cryoelectron tomography, we report that the P. gingivalis T9SS consists of 18 PorM dimers arranged as a large, caged ring in the periplasm. Near the outer membrane, PorM dimers interact with a PorKN ring complex of ∼52 nm in diameter. PorMKN translocation complexes of a given T9SS adopt distinct conformations energized by the proton motive force, suggestive of different activation states. At the inner membrane, PorM associates with a cytoplasmic complex that exhibits 12-fold symmetry and requires both PorM and PorL for assembly. Activated motors deliver substrates across the outer membrane via one of eight Sov translocons arranged in a ring. The T9SSs are unique among known secretion systems in bacteria and eukaryotes in their assembly as supramolecular machines composed of apparently independently functioning translocation motors and export pores.
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