negative regulation of sodium ion transmembrane transport / retromer, cargo-selective complex / WNT ligand biogenesis and trafficking / plasma membrane to endosome transport / cytoplasmic sequestering of NF-kappaB / retromer complex / regulation of proteasomal ubiquitin-dependent protein catabolic process / endosome transport via multivesicular body sorting pathway / negative regulation of protein localization to cell surface / copper ion homeostasis ...negative regulation of sodium ion transmembrane transport / retromer, cargo-selective complex / WNT ligand biogenesis and trafficking / plasma membrane to endosome transport / cytoplasmic sequestering of NF-kappaB / retromer complex / regulation of proteasomal ubiquitin-dependent protein catabolic process / endosome transport via multivesicular body sorting pathway / negative regulation of protein localization to cell surface / copper ion homeostasis / Golgi to plasma membrane transport / phosphatidic acid binding / positive regulation of ubiquitin-dependent protein catabolic process / phosphatidylinositol-3,4-bisphosphate binding / endocytic recycling / sodium channel inhibitor activity / retrograde transport, endosome to Golgi / phosphatidylinositol-3,5-bisphosphate binding / Cul2-RING ubiquitin ligase complex / regulation of early endosome to late endosome transport / sodium ion transport / negative regulation of NF-kappaB transcription factor activity / phosphatidylinositol-3,4,5-trisphosphate binding / cullin family protein binding / ficolin-1-rich granule membrane / NF-kappaB binding / intracellular copper ion homeostasis / negative regulation of canonical NF-kappaB signal transduction / tumor necrosis factor-mediated signaling pathway / phosphatidylinositol-4,5-bisphosphate binding / guanyl-nucleotide exchange factor activity / positive regulation of protein ubiquitination / cholesterol homeostasis / nucleotide-excision repair / intracellular protein transport / recycling endosome / small GTPase binding / protein transport / late endosome / Neddylation / cytoplasmic vesicle / secretory granule lumen / positive regulation of canonical NF-kappaB signal transduction / ficolin-1-rich granule lumen / early endosome / endosome membrane / endosome / copper ion binding / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / centrosome / Neutrophil degranulation / Golgi apparatus / protein homodimerization activity / extracellular region / nucleoplasm / identical protein binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function
DENN domain-containing protein 10 / Stabilization of polarity axis / COMM domain-containing protein 2 / COMM domain-containing protein 3 / COMM domain-containing protein 4 / : / COMMD1 N-terminal domain / COMM domain-containing protein 1 / COMM domain-containing protein 5 / COMM domain-containing protein 7 ...DENN domain-containing protein 10 / Stabilization of polarity axis / COMM domain-containing protein 2 / COMM domain-containing protein 3 / COMM domain-containing protein 4 / : / COMMD1 N-terminal domain / COMM domain-containing protein 1 / COMM domain-containing protein 5 / COMM domain-containing protein 7 / COMM domain-containing protein 10 / Tripartite DENN domain / : / COMMD1 N-terminal domain / COMMD2-7/10, HN domain / Tripartite DENN domain profile. / Coiled-coil domain-containing protein 22 / CCDC93, coiled-coil domain / Coiled-coil domain-containing protein 93 / : / : / : / CCDC22 protein coiled-coil region / CCDC93 coiled-coil domain / CCDC93 protein N-terminal domain / CCDC22 protein N-terminal domain / COMM domain-containing protein 9 / : / COMMD9, helical N-terminal domain / COMM domain / VPS35 endosomal protein sorting factor-like / COMM domain / COMM domain profile. / Vacuolar protein sorting protein 26 related / Vacuolar protein sorting-associated protein 26 / Vacuolar protein sorting-associated protein 29 / Phosphodiesterase MJ0936/Vps29 / Calcineurin-like phosphoesterase domain, lpxH-type / Calcineurin-like phosphoesterase superfamily domain / Arrestin-like, C-terminal / Metallo-dependent phosphatase-like / Immunoglobulin E-set Similarity search - Domain/homology
Vacuolar protein sorting-associated protein 26C / Coiled-coil domain-containing protein 22 / Coiled-coil domain-containing protein 93 / VPS35 endosomal protein-sorting factor-like / COMM domain-containing protein 6 / COMM domain-containing protein 7 / COMM domain-containing protein 2 / COMM domain-containing protein 1 / DENN domain-containing protein 10 / COMM domain-containing protein 5 ...Vacuolar protein sorting-associated protein 26C / Coiled-coil domain-containing protein 22 / Coiled-coil domain-containing protein 93 / VPS35 endosomal protein-sorting factor-like / COMM domain-containing protein 6 / COMM domain-containing protein 7 / COMM domain-containing protein 2 / COMM domain-containing protein 1 / DENN domain-containing protein 10 / COMM domain-containing protein 5 / COMM domain-containing protein 4 / COMM domain-containing protein 8 / COMM domain-containing protein 9 / COMM domain-containing protein 3 / Vacuolar protein sorting-associated protein 29 / COMM domain-containing protein 10 Similarity search - Component
Biological species
Homo sapiens (human)
Method
single particle reconstruction / cryo EM / Resolution: 3.3 Å
Journal: Nat Struct Mol Biol / Year: 2024 Title: Structure and interactions of the endogenous human Commander complex. Authors: Saara Laulumaa / Esa-Pekka Kumpula / Juha T Huiskonen / Markku Varjosalo / Abstract: The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle and immune response. It consists of copper-metabolism Murr1 domain proteins (COMMD1-10), coiled-coil ...The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle and immune response. It consists of copper-metabolism Murr1 domain proteins (COMMD1-10), coiled-coil domain-containing proteins (CCDC22 and CCDC93), DENND10 and the Retriever subcomplex (VPS26C, VPS29 and VPS35L), all expressed ubiquitously in the body and linked to various diseases. Here, we report the structure and key interactions of the endogenous human Commander complex by cryogenic-electron microscopy and mass spectrometry-based proteomics. The complex consists of a stable core of COMMD1-10 and an effector containing DENND10 and Retriever, scaffolded together by CCDC22 and CCDC93. We establish the composition of Commander and reveal major interaction interfaces. These findings clarify its roles in intracellular transport, and uncover a strong association with cilium assembly, and centrosome and centriole functions.
Name: Human Commander Complex / type: complex / ID: 1 / Parent: 0 / Macromolecule list: all Details: Sample contains all components of the complex. However, only COMMD1-10, and parts of CCDC93 and CCDC22 are visible in this map.
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