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Open data
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Basic information
Entry | ![]() | |||||||||
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Title | Human MUC5B amino acids 26-1435 | |||||||||
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![]() | Mucin / Filament / D assemblies / disulfide bonds / STRUCTURAL PROTEIN | |||||||||
Function / homology | ![]() Defective GALNT3 causes HFTC / Defective C1GALT1C1 causes TNPS / Defective GALNT12 causes CRCS1 / Termination of O-glycan biosynthesis / O-linked glycosylation of mucins / Dectin-2 family / extracellular matrix / Golgi lumen / intracellular membrane-bounded organelle / extracellular space ...Defective GALNT3 causes HFTC / Defective C1GALT1C1 causes TNPS / Defective GALNT12 causes CRCS1 / Termination of O-glycan biosynthesis / O-linked glycosylation of mucins / Dectin-2 family / extracellular matrix / Golgi lumen / intracellular membrane-bounded organelle / extracellular space / extracellular exosome / metal ion binding / plasma membrane Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | single particle reconstruction / cryo EM / Resolution: 3.0 Å | |||||||||
![]() | Khmelnitsky L / Javitt G / Elad N / Fass D | |||||||||
Funding support | ![]()
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![]() | ![]() Title: Pulmonary Fibrosis Mutation impairs Mucin 5B Supramolecular Assembly Authors: Khmelnitsky L / Javitt G / Reznik N / Yeshaya N / Elad N / Anikster Y / Shalva N / Barel O / Pode-Shakked B / Greenberg LJ / Segel MJ / Fass D | |||||||||
History |
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Structure visualization
Supplemental images |
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Downloads & links
-EMDB archive
Map data | ![]() | 1.2 GB | ![]() | |
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Header (meta data) | ![]() ![]() | 14.2 KB 14.2 KB | Display Display | ![]() |
Images | ![]() | 63.1 KB | ||
Filedesc metadata | ![]() | 5.4 KB | ||
Others | ![]() ![]() | 1.2 GB 1.2 GB | ||
Archive directory | ![]() ![]() | HTTPS FTP |
-Validation report
Summary document | ![]() | 1.3 MB | Display | ![]() |
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Full document | ![]() | 1.3 MB | Display | |
Data in XML | ![]() | 23.7 KB | Display | |
Data in CIF | ![]() | 28.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 8oerM ![]() 8oesM M: atomic model generated by this map |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
EMDB pages | ![]() ![]() |
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Related items in Molecule of the Month |
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Map
File | ![]() | ||||||||||||||||||||
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Voxel size | X=Y=Z: 0.8264 Å | ||||||||||||||||||||
Density |
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Symmetry | Space group: 1 | ||||||||||||||||||||
Details | EMDB XML:
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-Supplemental data
-Half map: #1
File | emd_16808_half_map_1.map | ||||||||||||
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Projections & Slices |
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Density Histograms |
-Half map: #2
File | emd_16808_half_map_2.map | ||||||||||||
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Projections & Slices |
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Density Histograms |
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Sample components
-Entire : MUC5B amino acids 26-1435
Entire | Name: MUC5B amino acids 26-1435 |
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Components |
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-Supramolecule #1: MUC5B amino acids 26-1435
Supramolecule | Name: MUC5B amino acids 26-1435 / type: complex / ID: 1 / Parent: 0 / Macromolecule list: all |
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Source (natural) | Organism: ![]() |
-Macromolecule #1: MUC5B
Macromolecule | Name: MUC5B / type: protein_or_peptide / ID: 1 / Enantiomer: LEVO |
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Source (natural) | Organism: ![]() |
Recombinant expression | Organism: ![]() |
Sequence | String: QGPVEPSWEN AGHTMDGGAP TSSPTRRVSF VPPVTVFPSL SPLNPAHNGR VCSTWGDFHY KTFDGDVFRF PGLCNYVFSE HCRAAYEDFN VQLRRGLVGS RPVVTRVVIK AQGLVLEASN GSVLINGQRE ELPYSRTGLL VEQSGDYIKV SIRLVLTFLW NGEDSALLEL ...String: QGPVEPSWEN AGHTMDGGAP TSSPTRRVSF VPPVTVFPSL SPLNPAHNGR VCSTWGDFHY KTFDGDVFRF PGLCNYVFSE HCRAAYEDFN VQLRRGLVGS RPVVTRVVIK AQGLVLEASN GSVLINGQRE ELPYSRTGLL VEQSGDYIKV SIRLVLTFLW NGEDSALLEL DPKYANQTCG LCGDFNGLPA FNEFYAHNAR LTPLQFGNLQ KLDGPTEQCP DPLPLPAGNC TDEEGICHRT LLGPAFAECH ALVDSTAYLA ACAQDLCRCP TCPCATFVEY SRQCAHAGGQ PRNWRCPELC PRTCPLNMQH QECGSPCTDT CSNPQRAQLC EDHCVDGCFC PPGTVLDDIT HSGCLPLGQC PCTHGGRTYS PGTSFNTTCS SCTCSGGLWQ CQDLPCPGTC SVQGGAHIST YDEKLYDLHG DCSYVLSKKC ADSSFTVLAE LRKCGLTDNE NCLKAVTLSL DGGDTAIRVQ ADGGVFLNSI YTQLPLSAAN ITLFTPSSFF IVVQTGLGLQ LLVQLVPLMQ VFVRLDPAHQ GQMCGLCGNF NQNQADDFTA LSGVVEATGA AFANTWKAQA ACANARNSFE DPCSLSVENE NYARHWCSRL TDPNSAFSRC HSIINPKPFH SNCMFDTCNC ERSEDCLCAA LSSYVHACAA KGVQLSDWRD GVCTKYMQNC PKSQRYAYVV DACQPTCRGL SEADVTCSVS FVPVDGCTCP AGTFLNDAGA CVPAQECPCY AHGTVLAPGE VVHDEGAVCS CTGGKLSCLG ASLQKSTGCA APMVYLDCSN SSAGTPGAEC LRSCHTLDVG CFSTHCVSGC VCPPGLVSDG SGGCIAEEDC PCVHNEATYK PGETIRVDCN TCTCRNRRWE CSHRLCLGTC VAYGDGHFIT FDGDRYSFEG SCEYILAQDY CGDNTTHGTF RIVTENIPCG TTGTTCSKAI KLFVESYELI LQEGTFKAVA RGPGGDPPYK IRYMGIFLVI ETHGMAVSWD RKTSVFIRLH QDYKGRVCGL CGNFDDNAIN DFATRSRSVV GDALEFGNSW KLSPSCPDAL APKDPCTANP FRKSWAQKQC SILHGPTFAA CRSQVDSTKY YEACVNDACA CDSGGDCECF CTAVAAYAQA CHDAGLCVSW RTPDTCPLFC DFYNPHGGCE WHYQPCGAPC LKTCRNPSGH CLVDLPGLEG CYPKCPPSQP FFNEDQMKCV AQCGCYDKDG NYYDVGARVP TAENCQSCNC TPSGIQCAHS LEACTCTYED RTYSYQDVIY NTTDGLGACL IAICGSNGTI IRKAVACPGT PATTPFTFTT AWVPHSTTSP ALPVSTVCVR EVCRWSSWYN GHRPEPGLGG GDFETFENLR QRGYQVCPVL ADIECRAAQL PDMPLEELGQ QVDCDRMRGL MCANSQQSPP LCHDYELRVL CCEYVPCGPS HHHHHH |
-Experimental details
-Structure determination
Method | cryo EM |
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![]() | single particle reconstruction |
Aggregation state | filament |
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Sample preparation
Concentration | 0.45 mg/mL |
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Buffer | pH: 5.2 / Component - Concentration: 100.0 mM / Component - Formula: C6H13NO4S / Component - Name: MES |
Vitrification | Cryogen name: ETHANE / Chamber humidity: 100 % / Chamber temperature: 277 K |
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Electron microscopy
Microscope | FEI TITAN KRIOS |
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Image recording | Film or detector model: GATAN K3 BIOQUANTUM (6k x 4k) / Average electron dose: 48.0 e/Å2 |
Electron beam | Acceleration voltage: 300 kV / Electron source: ![]() |
Electron optics | Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.0 µm / Nominal defocus min: 0.5 µm |
Experimental equipment | ![]() Model: Titan Krios / Image courtesy: FEI Company |
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Image processing
Startup model | Type of model: NONE |
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Final reconstruction | Resolution.type: BY AUTHOR / Resolution: 3.0 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 88708 |
Initial angle assignment | Type: PROJECTION MATCHING |
Final angle assignment | Type: PROJECTION MATCHING |