登録情報 データベース : EMDB / ID : EMD-16718 ダウンロードとリンクタイトル Drosophila melanogaster insulin receptor ectodomain in complex with DILP5 マップデータPrimary Map masked 詳細 試料複合体 : Drosophila insulin receptor ectodomain with DILP-5複合体 : Drosophila insulin-like peptide 5タンパク質・ペプチド : Probable insulin-like peptide 5 A chainタンパク質・ペプチド : Probable insulin-like peptide 5タンパク質・ペプチド : Insulin-like receptor 詳細 キーワード DILP5 hormone / Drosophila insulin-like signalling receptor / disulfide linked ectodomain / SIGNALING PROTEIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
primary spermatocyte growth / negative regulation of peptide hormone secretion / Extra-nuclear estrogen signaling / germ-line stem-cell niche homeostasis / negative regulation of entry into reproductive diapause / Insulin signaling pathway / Insulin receptor recycling / female mating behavior / response to anoxia / male germ-line stem cell asymmetric division ... primary spermatocyte growth / negative regulation of peptide hormone secretion / Extra-nuclear estrogen signaling / germ-line stem-cell niche homeostasis / negative regulation of entry into reproductive diapause / Insulin signaling pathway / Insulin receptor recycling / female mating behavior / response to anoxia / male germ-line stem cell asymmetric division / female germ-line stem cell population maintenance / germ-band shortening / embryonic development via the syncytial blastoderm / carbohydrate homeostasis / negative regulation of circadian sleep/wake cycle, sleep / imaginal disc growth / open tracheal system development / germ-line stem cell division / positive regulation of neuron remodeling / follicle cell of egg chamber development / lymph gland development / intestinal stem cell homeostasis / female germ-line stem cell asymmetric division / positive regulation of border follicle cell migration / positive regulation of fat cell proliferation / positive regulation of organ growth / positive regulation of lipid storage / insulin receptor complex / insulin receptor activity / regulation of organ growth / sleep / positive regulation of multicellular organism growth / lipid homeostasis / triglyceride homeostasis / embryo development ending in birth or egg hatching / insulin binding / positive regulation of wound healing / negative regulation of feeding behavior / positive regulation of neuroblast proliferation / female gonad development / positive regulation of cell size / insulin receptor substrate binding / regulation of multicellular organism growth / developmental growth / phosphatidylinositol 3-kinase binding / cell surface receptor protein tyrosine kinase signaling pathway / cellular response to starvation / negative regulation of autophagy / response to cocaine / cholesterol homeostasis / axon guidance / locomotory behavior / determination of adult lifespan / receptor protein-tyrosine kinase / insulin receptor binding / circadian rhythm / multicellular organism growth / hormone activity / SH3 domain binding / glucose homeostasis / insulin receptor signaling pathway / nervous system development / positive regulation of cell growth / regulation of cell population proliferation / protein tyrosine kinase activity / protein autophosphorylation / response to oxidative stress / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / protein phosphorylation / axon / positive regulation of cell population proliferation / extracellular space / extracellular region / ATP binding / identical protein binding / metal ion binding / plasma membrane 類似検索 - 分子機能 Insulin-related peptide, invertebrates / Long hematopoietin receptor, single chain family signature. / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Tyrosine-protein kinase, receptor class II, conserved site ... Insulin-related peptide, invertebrates / Long hematopoietin receptor, single chain family signature. / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin-like superfamily / Growth factor receptor cysteine-rich domain superfamily / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 Insulin-like receptor / Probable insulin-like peptide 5 類似検索 - 構成要素生物種 Drosophila melanogaster (キイロショウジョウバエ)手法 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 4.0 Å 詳細 データ登録者Viola CM / Brzozowski AM / Shafi T 資金援助 英国, 2件 詳細 詳細を隠すOrganization Grant number 国 Medical Research Council (MRC, United Kingdom) MR/R009066/1 英国 Biotechnology and Biological Sciences Research Council (BBSRC) BB/W003783/1 英国
引用ジャーナル : Nat Commun / 年 : 2023タイトル : Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.著者 : Cristina M Viola / Orsolya Frittmann / Huw T Jenkins / Talha Shafi / Pierre De Meyts / Andrzej M Brzozowski / 要旨 : The insulin-related hormones regulate key life processes in Metazoa, from metabolism to growth, lifespan and aging, through an evolutionarily conserved insulin signalling axis (IIS). In humans the ... The insulin-related hormones regulate key life processes in Metazoa, from metabolism to growth, lifespan and aging, through an evolutionarily conserved insulin signalling axis (IIS). In humans the IIS axis is controlled by insulin, two insulin-like growth factors, two isoforms of the insulin receptor (hIR-A and -B), and its homologous IGF-1R. In Drosophila, this signalling engages seven insulin-like hormones (DILP1-7) and a single receptor (dmIR). This report describes the cryoEM structure of the dmIR ectodomain:DILP5 complex, revealing high structural homology between dmIR and hIR. The excess of DILP5 yields dmIR complex in an asymmetric 'T' conformation, similar to that observed in some complexes of human IRs. However, dmIR binds three DILP5 molecules in a distinct arrangement, showing also dmIR-specific features. This work adds structural support to evolutionary conservation of the IIS axis at the IR level, and also underpins a better understanding of an important model organism. 履歴 登録 2023年2月17日 - ヘッダ(付随情報) 公開 2023年12月20日 - マップ公開 2023年12月20日 - 更新 2023年12月20日 - 現状 2023年12月20日 処理サイト : PDBe / 状態 : 公開
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