Biotechnology and Biological Sciences Research Council (BBSRC)
BB/S000917/1
United Kingdom
Biotechnology and Biological Sciences Research Council (BBSRC)
BB/W005581/1
United Kingdom
Wellcome Trust
210701/Z/18/Z
United Kingdom
Wellcome Trust
202904/Z/16/Z
United Kingdom
Wellcome Trust
206181/Z/17/Z
United Kingdom
Biotechnology and Biological Sciences Research Council (BBSRC)
BB/L01386X1
United Kingdom
Citation
Journal: Sci Adv / Year: 2022 Title: Molecular architecture of the autoinhibited kinesin-1 lambda particle. Authors: Johannes F Weijman / Sathish K N Yadav / Katherine J Surridge / Jessica A Cross / Ufuk Borucu / Judith Mantell / Derek N Woolfson / Christiane Schaffitzel / Mark P Dodding / Abstract: Despite continuing progress in kinesin enzyme mechanochemistry and emerging understanding of the cargo recognition machinery, it is not known how these functions are coupled and controlled by the α- ...Despite continuing progress in kinesin enzyme mechanochemistry and emerging understanding of the cargo recognition machinery, it is not known how these functions are coupled and controlled by the α-helical coiled coils encoded by a large component of kinesin protein sequences. Here, we combine computational structure prediction with single-particle negative-stain electron microscopy to reveal the coiled-coil architecture of heterotetrameric kinesin-1 in its compact state. An unusual flexion in the scaffold enables folding of the complex, bringing the kinesin heavy chain-light chain interface into close apposition with a tetrameric assembly formed from the region of the molecule previously assumed to be the folding hinge. This framework for autoinhibition is required to uncover how engagement of cargo and other regulatory factors drives kinesin-1 activation.
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