- EMDB-14750: Delta SARS-CoV-2 spike protein in complex with REGN10987 Fab homo... -
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Basic information
Entry
Database: EMDB / ID: EMD-14750
Title
Delta SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue.
Map data
Composite map created with locally sharpened RBD-FAB structure after local refinement and a C1 map of the complex. See a C1 map with the half-maps attached.
Sample
Complex: Delta SARS-CoV-2 S-protein + REGN10987 Fab homologue
Complex: Delta SARS-CoV-2 S-protein
Protein or peptide: Spike glycoproteinSpike protein
Complex: REGN10987 Fab homologue
Protein or peptide: REGN10987 Fab homologue (Light chain)
Protein or peptide: REGN10987 Fab homologue (Heavy chain)
Function / homology
Function and homology information
Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / host cell endoplasmic reticulum-Golgi intermediate compartment membrane ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / entry receptor-mediated virion attachment to host cell / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / membrane / identical protein binding / plasma membrane Similarity search - Function
#259 - Jul 2021 Designed Proteins and Citizen Science similarity (1)
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Map
File
Download / File: emd_14750.map.gz / Format: CCP4 / Size: 216 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Annotation
Composite map created with locally sharpened RBD-FAB structure after local refinement and a C1 map of the complex. See a C1 map with the half-maps attached.
Film or detector model: FEI FALCON IV (4k x 4k) / Average electron dose: 50.0 e/Å2
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company
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Image processing
Initial angle assignment
Type: MAXIMUM LIKELIHOOD / Software - Name: RELION (ver. 3.1)
Final angle assignment
Type: MAXIMUM LIKELIHOOD / Software - Name: crYOLO (ver. 3.3.1)
Final reconstruction
Resolution.type: BY AUTHOR / Resolution: 2.6 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: crYOLO (ver. 3.3.1) Details: FSC is reported for C1 map after global refinement and doesn't represent the resolution of the RBD-FAB areas. Number images used: 44323
FSC plot (resolution estimation)
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