登録情報 | データベース: EMDB / ID: EMD-14083 |
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タイトル | 26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS) |
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マップデータ | |
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試料 | - 複合体: 26S proteasome WT-Ubp6-UbVS complex in the si state
- 複合体: yeast WT 26S proteasome body2 (ATPase, Rpn1)
- 複合体: Ubp6-UbVS
- リガンド: x 3種
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機能・相同性 | 機能・相同性情報
proteasome regulatory particle assembly / proteasome-activating activity / proteasome regulatory particle, base subcomplex / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / KEAP1-NFE2L2 pathway / CDK-mediated phosphorylation and removal of Cdc6 / Neddylation ...proteasome regulatory particle assembly / proteasome-activating activity / proteasome regulatory particle, base subcomplex / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / KEAP1-NFE2L2 pathway / CDK-mediated phosphorylation and removal of Cdc6 / Neddylation / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / regulation of protein catabolic process / Orc1 removal from chromatin / protein deubiquitination / MAPK6/MAPK4 signaling / proteasome storage granule / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / enzyme regulator activity / Neutrophil degranulation / proteasome complex / modification-dependent protein catabolic process / protein tag activity / protein-macromolecule adaptor activity / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / protein ubiquitination / ubiquitin protein ligase binding / endoplasmic reticulum / ATP hydrolysis activity / ATP binding / nucleus / cytoplasm類似検索 - 分子機能 26S Proteasome regulatory subunit 7 / 26S Proteasome regulatory subunit 6A / 26S proteasome regulatory subunit 8 / 26S Proteasome regulatory subunit 6B / 26S proteasome regulatory subunit P45-like / Ubiquitin carboxyl-terminal hydrolase 14-like / 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit / RPN1, N-terminal / 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal / RPN1 N-terminal domain ...26S Proteasome regulatory subunit 7 / 26S Proteasome regulatory subunit 6A / 26S proteasome regulatory subunit 8 / 26S Proteasome regulatory subunit 6B / 26S proteasome regulatory subunit P45-like / Ubiquitin carboxyl-terminal hydrolase 14-like / 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit / RPN1, N-terminal / 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal / RPN1 N-terminal domain / 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal / Proteasome/cyclosome repeat / Proteasome/cyclosome repeat / Proteasomal ATPase OB C-terminal domain / Proteasomal ATPase OB C-terminal domain / Ubiquitin specific protease (USP) domain signature 2. / Ubiquitin specific protease (USP) domain signature 1. / Ubiquitin specific protease, conserved site / Peptidase C19, ubiquitin carboxyl-terminal hydrolase / Ubiquitin carboxyl-terminal hydrolase / Ubiquitin specific protease domain / Ubiquitin specific protease (USP) domain profile. / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / Papain-like cysteine peptidase superfamily / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Ubiquitin domain signature. / Ubiquitin conserved site / Ubiquitin domain / Armadillo-like helical / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Armadillo-type fold / Ubiquitin-like domain superfamily / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Nucleic acid-binding, OB-fold / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 RPT1 isoform 1 / RPT6 isoform 1 / Ubiquitin carboxyl-terminal hydrolase / RPT3 isoform 1 / RPT2 isoform 1 / RPT5 isoform 1 / RPT4 isoform 1 / Ubiquitin B / 26S proteasome regulatory subunit RPN1類似検索 - 構成要素 |
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生物種 | ![](img/tx_yeast.gif) Saccharomyces cerevisiae (パン酵母) / ![](img/tx_yeast.gif) baker's yeast (パン酵母) / Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 7.0 Å |
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データ登録者 | Hung KYS / Klumpe S / Eisele MR / Elsasser S / Geng TT / Cheng C / Joshi T / Rudack T / Sakata E / Finley D |
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資金援助 | ドイツ, 5件 Organization | Grant number | 国 |
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German Research Foundation (DFG) | EXC 2067/1- 390729940 | ドイツ | German Research Foundation (DFG) | SFB1035/Project A01 | ドイツ | German Research Foundation (DFG) | CRC889/Project A11 | ドイツ | Other government | Foundation for the National Institutes of Health R01 GM043601 | | Other government | Marie Curie Career Integration grant (PCIG14-GA-2013-631577) | |
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引用 | ジャーナル: Nat Commun / 年: 2022 タイトル: Allosteric control of Ubp6 and the proteasome via a bidirectional switch. 著者: Hung KYS / Klumpe S / Eisele MR / Elsasser S / Tian G / Sun S / Moroco JA / Cheng TC / Joshi T / Seibel T / Van Dalen D / Feng XH / Lu Y / Ovaa H / Engen JR / Lee BH / Rudack T / Sakata E / Finley D |
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履歴 | 登録 | 2021年12月23日 | - |
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ヘッダ(付随情報) 公開 | 2022年6月1日 | - |
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マップ公開 | 2022年6月1日 | - |
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更新 | 2022年6月1日 | - |
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現状 | 2022年6月1日 | 処理サイト: PDBe / 状態: 公開 |
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