BIRD-PRD_000723: PYOVERDIN C-E Fe Complex

基本情報

• 登録情報: データベース: 生物学的重要分子辞書 (BIRD) / ID: PRD_000723
• 状態: 状態: REF ONLY
• 名称: PYOVERDIN C-E Fe Complex

BIRD information

• タイプ: ポリペプチド / Metal Transport

詳細

• PYOVERDINES ARE A GROUP OF STRUCTURALLY RELATED SIDEROPHORES PRODUCED BY FLUORESCENT PSEUDOMONAS SPECIES. PYOVERDINE IS NECESSARY FOR INFECTION IN SEVERAL DIFFERENT DISEASE MODELS. THE OCCURRENCE OF PYOVERDINE-DEFECTIVE STRAINS IN CHRONIC INFECTIONS OF PATIENTS WITH CYSTIC FIBROSIS AND THE EXTREMELY HIGH SEQUENCE DIVERSITY OF GENES INVOLVED IN PYOVERDINE SYNTHESIS AND UPTAKE INDICATE THAT PYOVERDINE PRODUCTION IS SUBJECT TO HIGH EVOLUTIONARY PRESSURE. PYOVERDINE-DEPENDENT IRON TRANSPORT IS ALSO CRUCIAL FOR BIOFILM DEVELOPMENT, FURTHER EXPANDING THE IMPORTANCE OF THESE SIDEROPHORES IN PSEUDOMONAS BIOLOGY.
• IN IRON-DEFICIENT CONDITIONS, PSEUDOMONAS AERUGINOSA SECRETES A MAJOR FLUORESCENT SIDEROPHORE NAMED PYOVERDIN (PVD), WHICH AFTER CHELATING IRON(III) IS TRANSPORTED BACK INTO THE CELL VIA ITS OUTER MEMBRANE RECEPTOR FPVA. FPVA IS A TONB-DEPENDENT TRANSPORT PROTEIN AND HAS THE ABILITY TO BIND PVD IN ITS APO- OR IRON-LOADED FORM.

• ダウンロード: Molecular definition / Chemical definition / Family definition

Annotation

• 分子機能: iron binding / 情報源: PubMed: 19504741

由来

• PSEUDOMONAS AERUGINOSA, STRAIN PAO1, Norine: NOR00190

External info

• Norine: NOR00190

Family

PYOVERDINE

PYOVERDIN C-E CHROMOPHORE / PYOVERDIN C-E Fe Complex / PYOVERDIN 18-1 Fe Complex / PYOVERDIN R Fe Complex / BIRD: PRD_000726 / PYOVERDIN G173 Fe Complex / Synthetic PYOVERDINE Fe Complex

Chemical information

組成

組成式: C₅₅H₈₂FeN₁₇O₂₂ / 化学式量: 1389.185

• その他: タイプ: peptide-like

履歴

• 外部リンク: UniChem / ChemSpider / Wikipedia search / Google search

詳細

SMILES

• ACDLabs 12.01: O=C(O)CCC(=O)Nc3cc9c2cc8o[Fe+3]615(ocn(o1)CCCC7C(=O)NC(C(=O)NC(C(=O)[NH2+]CCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C4[n+]2c3NCC4)CO)CCCNC(=[NH2+])\N)CO)CCCn(o5)co6)C(=O)N7)C(O)C)C(O)C)oc8c9
• CACTVS 3.370: C[CH](O)[CH]1NC(=O)[CH]2CCC[N]3O[Fe+3]456(|O=C[N](CCC[CH](NC(=O)[CH](CO)NC(=O)[CH](CCCNC(N)=[NH2+])NC(=O)[CH](CO)NC(=O)[CH]7CCNc8c(NC(=O)CCC(O)=O)cc9cc(O4)c(O5)cc9[n+]78)C(=O)N[CH](CCCC[NH2+]C(=O)[CH](NC1=O)[CH](C)O)C(=O)N2)O6)|O=C3
• OpenEye OEToolkits 1.7.6: CC(C1C(=O)[NH2+]CCCCC2C(=O)NC(CCCN3C=O[Fe+3]456(O3)O=CN(O4)CCCC(C(=O)N2)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C7CCNc8[n+]7c9cc(c(cc9cc8NC(=O)CCC(=O)O)O5)O6)CO)CCCNC(=[NH2+])N)CO)C(=O)NC(C(=O)N1)C(C)O)O

SMILES CANONICAL

• CACTVS 3.370: C[C@@H](O)[C@@H]1NC(=O)[C@@H]2CCC[N@@]3O[Fe+3]456(|O=C[N@](CCC[C@H](NC(=O)[C@@H](CO)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H](CO)NC(=O)[C@@H]7CCNc8c(NC(=O)CCC(O)=O)cc9cc(O4)c(O5)cc9[n+]78)C(=O)N[C@@H](CCCC[NH2+]C(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N2)O6)|O=C3
• OpenEye OEToolkits 1.7.6: C[C@H]([C@H]1C(=O)[NH2+]CCCC[C@H]2C(=O)N[C@@H](CCCN3C=O[Fe+3]456(O3)O=CN(O4)CCC[C@@H](C(=O)N2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H]7CCNc8[n+]7c9cc(c(cc9cc8NC(=O)CCC(=O)O)O5)O6)CO)CCCNC(=[NH2+])N)CO)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)O

InChI

• InChI 1.03: InChI=1S/C55H81N17O22.Fe/c1-27(77)43-53(91)59-15-4-3-8-30(46(84)63-33(11-7-19-71(94)26-76)49(87)68-44(28(2)78)54(92)69-43)62-47(85)32(10-6-18-70(93)25-75)65-50(88)35(23-73)66-48(86)31(9-5-16-60-55(56)57)64-51(89)36(24-74)67-52(90)37-14-17-58-45-34(61-41(81)12-13-42(82)83)20-29-21-39(79)40(80)22-38(29)72(37)45;/h20-22,25-28,30-33,35-37,43-44,73-74,77-78H,3-19,23-24H2,1-2H3,(H17,56,57,58,59,60,61,62,63,64,65,66,67,68,69,79,80,81,82,83,84,85,86,87,88,89,90,91,92);/q-2;+7/p+1

InChIKey

• InChI 1.03: REEJEWYDVJJOLS-UHFFFAOYSA-O

SYSTEMATIC NAME

• ACDLabs 12.01: [N-{[(1R)-5-[(3-carboxypropanoyl)amino]-8,9-di(hydroxy-kappaO)-1,2,3,4-tetrahydropyrimido[1,2-a]quinolin-11-ium-1-yl]carbonyl}-D-seryl-N~5~-[amino(iminio)methyl]-L-ornithyl-D-seryl-N~5~-formyl-kappaO-N-{(3R,6S,9S,12R)-9-{3-[(formyl-kappaO)(hydroxy-kappaO)amino]propyl}-6-[(1R)-1-hydroxyethyl]-3-[(1S)-1-hydroxyethyl]-2,5,8,11-tetraoxo-4,7,10-triaza-1-azoniacyclohexadecan-12-yl}-N~5~-hydroxy-kappaO-L-ornithinamidato(4-)]iron(6+) #

PDBエントリ

全6件を表示しています

PDB-2iah:
Crystal structure of the ferripyoverdine receptor of the outer membrane of Pseudomonas aeruginosa bound to ferripyoverdine.

PDB-2iah:
Crystal structure of the ferripyoverdine receptor of the outer membrane of Pseudomonas aeruginosa bound to ferripyoverdine.

PDB-2iah:
Crystal structure of the ferripyoverdine receptor of the outer membrane of Pseudomonas aeruginosa bound to ferripyoverdine.

PDB-2w16:
Structures of FpvA bound to heterologous pyoverdines

PDB-2w16:
Structures of FpvA bound to heterologous pyoverdines

PDB-2w16:
Structures of FpvA bound to heterologous pyoverdines