BIRD-PRD_000298: N-[(2R)-3-phenyl-2-{[L-prolyl-L-phenylalanyl-3-(1H-imidazol-3-ium...

Basic information

• Entry: Database: Biologically Interesting Molecule Reference Dictionary (BIRD) / ID: PRD_000298
• Status: Status: REF ONLY
• Name: N-[(2R)-3-phenyl-2-{[L-prolyl-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}propyl]-L-phenylalanyl-L-valylty rosine

BIRD information

• Type: Peptide-like / Inhibitor
• Downloads: Molecular definition / Chemical definition / Family definition

Synonyms

• D-His-Pro-Phe-His-Phe psi [CH2-NH]Phe-Val-Tyr (PDB)

Annotation

• Function: Compound D-His-Pro-Phe-His-Phe psi [CH2-NH]Phe-Val-Tyr, with a reduced bond between the two adjacent phenylalanines, inhibits Rhizopuspepsin (EC 3.4.23.6), an aspartic proteinase from Rhizopus chinensis / Info source: PubMed: 3313384

Family

PFHFrFVY reduced peptide inhibitor

N-[(2R)-3-phenyl-2-{[L-prolyl-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}propyl]-L-phenylalanyl-L-valylty rosine

Chemical information

Composition

Formula: C₅₈H₇₂N₁₂O₉ / Formula weight: 1081.267

• Others: Type: peptide-like

History

• External links: UniChem / ChemSpider / Wikipedia search / Google search

Details

SMILES

• ACDLabs 12.01: O=C(NC(C(=O)NC(C(=O)NC(Cc1ccccc1)CNC(C(=O)NC(C(=O)NC(C(=O)O)Cc2ccc(O)cc2)C(C)C)Cc3ccccc3)Cc4[nH+]cnc4)Cc5ccccc5)C7N(C(=O)C(N)Cc6[nH+]cnc6)CCC7
• CACTVS 3.370: CC(C)[CH](NC(=O)[CH](Cc1ccccc1)NC[CH](Cc2ccccc2)NC(=O)[CH](Cc3c[nH]c[nH+]3)NC(=O)[CH](Cc4ccccc4)NC(=O)[CH]5CCCN5C(=O)C(N)Cc6c[nH]c[nH+]6)C(=O)NC(Cc7ccc(O)cc7)C(O)=O
• OpenEye OEToolkits 1.7.6: CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)O)NC(=O)C(Cc2ccccc2)NCC(Cc3ccccc3)NC(=O)C(Cc4c[nH]c[nH+]4)NC(=O)C(Cc5ccccc5)NC(=O)C6CCCN6C(=O)C(Cc7c[nH]c[nH+]7)N

SMILES CANONICAL

• CACTVS 3.370: CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3c[nH]c[nH+]3)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H]5CCCN5C(=O)C(N)Cc6c[nH]c[nH+]6)C(=O)NC(Cc7ccc(O)cc7)C(O)=O
• OpenEye OEToolkits 1.7.6: CC(C)[C@@H](C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC[C@H](Cc3ccccc3)NC(=O)[C@H](Cc4c[nH]c[nH+]4)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H]6CCCN6C(=O)[C@H](Cc7c[nH]c[nH+]7)N

InChI

• InChI 1.03: InChI=1S/C58H70N12O9/c1-36(2)51(56(76)68-49(58(78)79)28-40-20-22-44(71)23-21-40)69-52(72)46(26-38-15-8-4-9-16-38)62-33-43(25-37-13-6-3-7-14-37)65-53(73)48(30-42-32-61-35-64-42)66-54(74)47(27-39-17-10-5-11-18-39)67-55(75)50-19-12-24-70(50)57(77)45(59)29-41-31-60-34-63-41/h3-11,13-18,20-23,31-32,34-36,43,45-51,62,71H,12,19,24-30,33,59H2,1-2H3,(H,60,63)(H,61,64)(H,65,73)(H,66,74)(H,67,75)(H,68,76)(H,69,72)(H,78,79)/p+2

InChIKey

• InChI 1.03: YPXOZWHSLYDQHQ-UHFFFAOYSA-P

SYSTEMATIC NAME

• ACDLabs 12.01: 3-(1H-imidazol-3-ium-4-yl)alanyl-L-prolyl-L-phenylalanyl-N-[(2R)-1-{[(2S)-1-{[(2R)-1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]amino}-3-methyl-1-oxobutan-2-yl]amino}-1-oxo-3-phenylpropan-2-yl]amino}-3-phenylpropan-2-yl]-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide
• OpenEye OEToolkits 1.7.6: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-azanyl-3-(1H-imidazol-3-ium-4-yl)propanoyl]pyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoyl]amino]-3-(1H-imidazol-3-ium-4-yl)propanoyl]amino]-3-phenyl-propyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-butanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid

PDB entries

Showing all 1 items

PDB-3apr:
BINDING OF A REDUCED PEPTIDE INHIBITOR TO THE ASPARTIC PROTEINASE FROM RHIZOPUS CHINENSIS. IMPLICATIONS FOR A MECHANISM OF ACTION