Type Oligopeptide / Lantibiotic Details ACTAGARDINE IS A TRICYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR AND SER INTO DEHYDRATED AMINO ACIDS AND THE FORMATION OF THIOETHER BONDS WITH CYSTEINE. THE THIOETHER BONDS WITH CYSTEINE RESULT IN THREE RING STRUCTURES. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE MODIFIED PRECURSOR. Downloads Molecular definition / Chemical definition / Family definitionSynonyms ACTAGARDINE (PDB) AIDS 187911 (PubChem) Actagardine (SciFinder, PubChem) Antibiotic A 3802-IV-3 (SciFinder) Gardimycin Actagardin (SciFinder, UniProt, PubChem) lantibiotic actagardine (UniProt) Show more 2 items Show lessAnnotation Function : Antibacterial Antibiotic / Info source : NovelAntibioticsFunction : lantibiotic Lantibiotics / Info source : BactibaseFunction : creates aqueous pores in membrane / Info source : BactibaseFunction : antibacterial activity against Gram-positive bacteria / Info source : UniProtFunction : good antistreptococcal activity / Info source : UniProtFunction : murein-biosynthesis-inhibitor / Info source : PubMed: 9219543Source External info Family Lantibiotic Lantibiotics ACTAGARDINE / Cinnamycin / EPILANCIN 15X ... ACTAGARDINE / Cinnamycin / EPILANCIN 15X / BIRD: PRD_000197 / BETA LICHENICIDIN PREPEPTIDE / Mersacidin / Nisin A
Related structures cysteinyl-(alpha-aminobutyryl)-phenylalanyl-(alpha-aminobutyryl)-leucyl-prolyl-glycyl-glycyl-glycyl-glycyl-valyl-cysteinyl-(alpha-aminobutyryl)-leucyl-(alpha-aminobutyryl)-(dehydroalanyl)-glutamyl-cysteinyl-isoleucine 2-sulfanylethenylamide methanol solvate hydrate, Mersacidin methanol solvate hydrate, seqres C9 CYS*!,GLY!-LEU-PRO-GLY-GLY-GLY-GLY-VAL-, C6 ALA!,CYS*!-LEU-CYS*-ALA*-GLU-, C2 CYS*-GLY!, A3 GLY!-PHE-GLY!, A2 ALA!-ILE, A2 CYS*!-CYS*! / CCDC: WOPCAF / Reference