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- BIRD-PRD_000194: ACTAGARDINE -

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ID or keywords:

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Basic information

EntryDatabase: Biologically Interesting Molecule Reference Dictionary (BIRD) / ID: PRD_000194
StatusStatus: REF ONLY
NameACTAGARDINE

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BIRD information

TypeOligopeptide / Lantibiotic
Details
  • ACTAGARDINE IS A TRICYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR AND SER INTO DEHYDRATED AMINO ACIDS AND THE FORMATION OF THIOETHER BONDS WITH CYSTEINE. THE THIOETHER BONDS WITH CYSTEINE RESULT IN THREE RING STRUCTURES. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE MODIFIED PRECURSOR.
DownloadsMolecular definition / Chemical definition / Family definition
Synonyms
  • ACTAGARDINE (PDB)
  • AIDS 187911 (PubChem)
  • Actagardine (SciFinder, PubChem)
  • Antibiotic A 3802-IV-3 (SciFinder)
  • GardimycinActagardin (SciFinder, UniProt, PubChem)
  • lantibiotic actagardine (UniProt)
Annotation
  • Function: AntibacterialAntibiotic / Info source: NovelAntibiotics
  • Function: lantibioticLantibiotics / Info source: Bactibase
  • Function: creates aqueous pores in membrane / Info source: Bactibase
  • Function: antibacterial activity against Gram-positive bacteria / Info source: UniProt
  • Function: good antistreptococcal activity / Info source: UniProt
  • Function: murein-biosynthesis-inhibitor / Info source: PubMed: 9219543
Source
External info
FamilyLantibioticLantibiotics

ACTAGARDINE / Cinnamycin / EPILANCIN 15X ...ACTAGARDINE / Cinnamycin / EPILANCIN 15X / BIRD: PRD_000197 / BETA LICHENICIDIN PREPEPTIDE / Mersacidin / Nisin A

Related structures
  • cysteinyl-(alpha-aminobutyryl)-phenylalanyl-(alpha-aminobutyryl)-leucyl-prolyl-glycyl-glycyl-glycyl-glycyl-valyl-cysteinyl-(alpha-aminobutyryl)-leucyl-(alpha-aminobutyryl)-(dehydroalanyl)-glutamyl-cysteinyl-isoleucine 2-sulfanylethenylamide methanol solvate hydrate, Mersacidin methanol solvate hydrate, seqres C9 CYS*!,GLY!-LEU-PRO-GLY-GLY-GLY-GLY-VAL-, C6 ALA!,CYS*!-LEU-CYS*-ALA*-GLU-, C2 CYS*-GLY!, A3 GLY!-PHE-GLY!, A2 ALA!-ILE, A2 CYS*!-CYS*! / CCDC: WOPCAF / Reference

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Chemical information

Composition
Formula: C81H124N20O23S4 / Formula weight: 1874.231
OthersType: peptide-like
History
External linksUniChem / ChemSpider / Wikipedia search / Google search

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Details

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SMILES

ACDLabs 12.01Too many bonds
CACTVS 3.370CC[CH](C)[CH]1NC(=O)[CH](NC(=O)[CH]2NC(=O)CNC(=O)[CH]3CS[CH](C)[CH](NC(=O)[CH]4CSC[CH](N)C(=O)N[CH](CO)C(=O)NCC(=O)N[CH](Cc5c[nH]c6ccccc56)C(=O)N[CH](C(C)C)C(=O)N4)C(=O)N[CH](CC(C)C)C(=O)N[CH]([CH](C)SC[CH](NC1=O)C(=O)N[CH](C)C(=O)N[CH](CS[CH]2C)C(O)=O)C(=O)N[CH]([CH](C)CC)C(=O)N[CH](CCC(O)=O)C(=O)N3)C(C)C
OpenEye OEToolkits 1.7.6CCC(C)C1C(=O)NC(C(=O)NC2CSC(C(C(=O)NC(C(=O)NC(C(SCC3C(=O)NC(C(=O)NC(CSC(C(C(=O)NC(C(=O)NC(C(=O)N3)C(C)CC)C(C)C)NC(=O)CNC2=O)C)C(=O)O)C)C)C(=O)N1)CC(C)C)NC(=O)C4CSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N4)C(C)C)Cc5c[nH]c6c5cccc6)CO)N)C)CCC(=O)O

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SMILES CANONICAL

CACTVS 3.370CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H]2NC(=O)CNC(=O)[C@@H]3CS[C@@H](C)[C@@H](NC(=O)[C@@H]4CSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc5c[nH]c6ccccc56)C(=O)N[C@@H](C(C)C)C(=O)N4)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]([C@H](C)SC[C@H](NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CS[C@H]2C)C(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N3)C(C)C
OpenEye OEToolkits 1.7.6CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CSC([C@H](C(=O)N[C@H](C(=O)N[C@H](C(SC[C@H]3C(=O)N[C@H](C(=O)N[C@@H](CSC([C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3)[C@@H](C)CC)C(C)C)NC(=O)CNC2=O)C)C(=O)O)C)C)C(=O)N1)CC(C)C)NC(=O)[C@@H]4CSC[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N4)C(C)C)Cc5c[nH]c6c5cccc6)CO)N)C)CCC(=O)O

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InChI

InChI 1.03InChI=1S/C81H124N20O23S4/c1-15-37(9)60-76(118)88-47(21-22-57(105)106)69(111)91-52-31-126-41(13)63(101-73(115)51-30-125-29-45(82)66(108)90-50(28-102)67(109)84-26-55(103)87-49(71(113)96-58(35(5)6)74(116)92-51)24-43-25-83-46-20-18-17-19-44(43)46)78(120)89-48(23-34(3)4)70(112)100-64(80(122)99-60)42(14)127-32-53-72(114)86-39(11)65(107)94-54(81(123)124)33-128-40(12)62(95-56(104)27-85-68(52)110)79(121)97-59(36(7)8)75(117)98-61(38(10)16-2)77(119)93-53/h17-20,25,34-42,45,47-54,58-64,83,102H,15-16,21-24,26-33,82H2,1-14H3,(H,84,109)(H,85,110)(H,86,114)(H,87,103)(H,88,118)(H,89,120)(H,90,108)(H,91,111)(H,92,116)(H,93,119)(H,94,107)(H,95,104)(H,96,113)(H,97,121)(H,98,117)(H,99,122)(H,100,112)(H,101,115)(H,105,106)(H,123,124)/t37-,38-,39-,40-,41-,42-,45+,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-,60-,61-,62+,63+,64+/m0/s1

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InChIKey

InChI 1.03BONKUOOMLCEDCZ-UAPKJGFDSA-N

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SYSTEMATIC NAME

ACDLabs 12.01(1R,4S,5S,8S,11S,12S,15R,21S,22S,25R,28S,33S,36S,41S,44S)-11-({[(3R,6S,9S,15S,18S)-18-amino-15-(hydroxymethyl)-9-(1H-indol-3-ylmethyl)-5,8,11,14,17-pentaoxo-6-(propan-2-yl)-1-thia-4,7,10,13,16-pentaazacyclononadecan-3-yl]carbonyl}amino)-33,44-di[(2S)-butan-2-yl]-41-(2-carboxyethyl)-4,12,22,28-tetramethyl-8-(2-methylpropyl)-7,10,16,19,27,30,32,35,38,40,43,46-dodecaoxo-36-(propan-2-yl)-3,13,23-trithia-6,9,17,20,26,29,31,34,37,39,42,45-dodecaazatricyclo[19.9.8.8~5,15~]hexatetracontane-25-carboxylic acid #

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PDB entries

Showing all 1 items

PDB-1aj1:
NMR STRUCTURE OF THE LANTIBIOTIC ACTAGARDINE

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