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Yorodumi- ChemComp-YP1: 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan... -
+Open data
-Basic information
Entry | Database: PDB chemical components / ID: YP1 | ||||
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Name | Name: Wikipedia | Wikipedia - NPS-2143: NPS-2143 is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents... | Comment | antagonist, hormone*YM | |
-Chemical information
Composition | Formula: C24H25ClN2O2 / Number of atoms: 54 / Formula weight: 408.921 / Formal charge: 0 | ||||
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Others | Type: non-polymer / PDB classification: HETAIN / Three letter code: YP1 / Ideal coordinates details: Corina | ||||
History |
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External links | UniChem / BindingDB / ChEMBL / ChemicalBook / CompTox / DrugBank / GtoPharmacology / Nikkaji / PubChem / PubChem_TPharma / SureChEMBL / ZINC / ChemSpider / Wikipedia search / Google search |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Details
-SMILES
ACDLabs 12.01 | CACTVS 3.385 | OpenEye OEToolkits 2.0.7 | |
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-SMILES CANONICAL
CACTVS 3.385 | OpenEye OEToolkits 2.0.7 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-SYSTEMATIC NAME
ACDLabs 12.01 | OpenEye OEToolkits 2.0.7 | |
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-PDB entries
Showing all 4 items
PDB-7dd5:
Structure of Calcium-Sensing Receptor in complex with NPS-2143
PDB-7m3e:
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
PDB-7m3j:
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
PDB-7sin:
Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor