[English] 日本語
![](img/lk-miru.gif)
- SASDGN9: Mutant Apolipoprotein E4 (K143A K146A) bound to 1 mg/mL heparin (... -
+
Open data
-
Basic information
Entry | ![]() |
---|---|
![]() | Mutant Apolipoprotein E4 (K143A K146A) bound to 1 mg/mL heparin (SEC-SAXS)
|
Function / homology | ![]() chylomicron remnant / lipid transport involved in lipid storage / triglyceride-rich lipoprotein particle clearance / intermediate-density lipoprotein particle clearance / positive regulation of lipid transport across blood-brain barrier / positive regulation of heparan sulfate proteoglycan binding / regulation of cellular response to very-low-density lipoprotein particle stimulus / metal chelating activity / Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors / discoidal high-density lipoprotein particle ...chylomicron remnant / lipid transport involved in lipid storage / triglyceride-rich lipoprotein particle clearance / intermediate-density lipoprotein particle clearance / positive regulation of lipid transport across blood-brain barrier / positive regulation of heparan sulfate proteoglycan binding / regulation of cellular response to very-low-density lipoprotein particle stimulus / metal chelating activity / Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors / discoidal high-density lipoprotein particle / chylomicron remnant clearance / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function |
Biological species | ![]() ![]() |
![]() |
|
-
Structure visualization
-
Downloads & links
-Data source
SASBDB page | ![]() |
---|
-Related structure data
Similar structure data | Similarity search - Function & homology ![]() |
---|
-
External links
Related items in Molecule of the Month |
---|
-Models
-
Sample
![]() | Name: Mutant Apolipoprotein E4 (K143A K146A) bound to 1 mg/mL heparin (SEC-SAXS) Specimen concentration: 10 mg/ml / Entity id: 1633 / 1634 |
---|---|
Buffer | Name: 20 mM HEPES, 300 mM NaCl, 1 mM TCEP / pH: 8 |
Entity #1633 | Type: other / Description: Heparin![]() Sequence: (C12H19NO20S3)n |
Entity #1634 | Name: ApoE4 (K143A K146A) / Type: protein / Description: Apolipoprotein E4 (K143A K146A) mutant / Formula weight: 34.598 / Num. of mol.: 4 / Source: Homo sapiens / References: UniProt: P02649 Sequence: GPHMKVEQAV ETEPEPELRQ QTEWQSGQRW ELALGRFWDY LRWVQTLSEQ VQEELLSSQV TQELRALMDE TMKELKAYKS ELEEQLTPVA EETRARLSKE LQAAQARLGA DMEDVRGRLV QYRGEVQAML GQSTEELRVR LASHLRALRA RLLRDADDLQ KRLAVYQAGA ...Sequence: GPHMKVEQAV ETEPEPELRQ QTEWQSGQRW ELALGRFWDY LRWVQTLSEQ VQEELLSSQV TQELRALMDE TMKELKAYKS ELEEQLTPVA EETRARLSKE LQAAQARLGA DMEDVRGRLV QYRGEVQAML GQSTEELRVR LASHLRALRA RLLRDADDLQ KRLAVYQAGA REGAERGLSA IRERLGPLVE QGRVRAATVG SLAGQPLQER AQAWGERLRA RMEEMGSRTR DRLDEVKEQV AEVRAKLEEQ AQQIRLQAEA FQARLKSWFE PLVEDMQRQW AGLVEKVQAA VGTSAAPVPS DNH |
-Experimental information
Beam | Instrument name: Diamond Light Source B21 / City: Didcot / 国: UK ![]() ![]() ![]() | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Detector | Name: Pilatus 2M | |||||||||||||||||||||
Scan | Measurement date: Jul 21, 2018 / Storage temperature: 20 °C / Cell temperature: 20 °C / Exposure time: 3 sec. / Number of frames: 11 / Unit: 1/A /
| |||||||||||||||||||||
Distance distribution function P(R) |
| |||||||||||||||||||||
Result | Comments: Mutant ApoE4 (K143A K146A) at 10 mg/mL was gel-filtered in 20 mM HEPES, 300 mM NaCl, 1 mM TCEP, 1 mg/mL heparin, pH 8.0.
|