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- SASDGM2: R16-24 del44-54 human dystrophin fragment (Human dystrophin centr... -

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Basic information

Entry
Database: SASBDB / ID: SASDGM2
SampleR16-24 del44-54 human dystrophin fragment
  • Human dystrophin central domain R16-24 del44-54 fragment (protein), Homo sapiens
Function / homology
Function and homology information


regulation of muscle system process / regulation of cellular response to growth factor stimulus / regulation of skeletal muscle contraction / syntrophin complex / synaptic signaling / cardiac muscle cell action potential / regulation of voltage-gated calcium channel activity / negative regulation of peptidyl-cysteine S-nitrosylation / positive regulation of sodium ion transmembrane transporter activity / dystrophin-associated glycoprotein complex ...regulation of muscle system process / regulation of cellular response to growth factor stimulus / regulation of skeletal muscle contraction / syntrophin complex / synaptic signaling / cardiac muscle cell action potential / regulation of voltage-gated calcium channel activity / negative regulation of peptidyl-cysteine S-nitrosylation / positive regulation of sodium ion transmembrane transporter activity / dystrophin-associated glycoprotein complex / regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / peptide biosynthetic process / cell-substrate junction / motile cilium assembly / dystroglycan binding / vinculin binding / muscle cell development / costamere / neuron projection terminus / Striated Muscle Contraction / filopodium membrane / muscle organ development / structural constituent of muscle / muscle cell cellular homeostasis / maintenance of blood-brain barrier / myosin binding / nitric-oxide synthase binding / Non-integrin membrane-ECM interactions / neuron development / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / negative regulation of peptidyl-serine phosphorylation / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / skeletal muscle tissue development / cardiac muscle contraction / regulation of ryanodine-sensitive calcium-release channel activity / response to muscle stretch / positive regulation of neuron differentiation / regulation of heart rate / filopodium / sarcolemma / protein localization / structural constituent of cytoskeleton / Z disc / positive regulation of neuron projection development / actin binding / postsynaptic membrane / protein-containing complex assembly / cytoskeleton / membrane raft / synapse / cell surface / protein-containing complex / zinc ion binding / nucleus / plasma membrane / cytosol
Similarity search - Function
Dystrophin/utrophin / EF-hand domain, type 1 / EF-hand domain, type 2 / EF hand / EF-hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. ...Dystrophin/utrophin / EF-hand domain, type 1 / EF-hand domain, type 2 / EF hand / EF-hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Spectrin repeats / Actinin-type actin-binding domain, conserved site / Calponin homology domain / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Calponin homology (CH) domain / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / EF-hand domain pair
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
Contact author
  • Raphael Dos Santos Morais (University of Lorraine, France)

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Structure visualization

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Models

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Sample

SampleName: R16-24 del44-54 human dystrophin fragment / Specimen concentration: 5 mg/ml
BufferName: 20 mM Na-phosphate, 300 mM NaCl, 1 mM EDTA, 2% glycerol,
pH: 7.5
Entity #1795Type: protein
Description: Human dystrophin central domain R16-24 del44-54 fragment
Formula weight: 56.982 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P11532
Sequence: TENLYFOGAM GRSLVPRGSL EISYVPSTYL TEITHVSQAL LEVEQLLNAP DLCAKDFEDL FKQEESLKNI KDSLQQSSGR IDIIHSKKTA ALQSATPVER VKLQEALSQL DFQWEKVNKM YKDRQGVSER EAALEETHRL LQQFPLDLEK FLAWLTEAET TANVLQDATR ...Sequence:
TENLYFOGAM GRSLVPRGSL EISYVPSTYL TEITHVSQAL LEVEQLLNAP DLCAKDFEDL FKQEESLKNI KDSLQQSSGR IDIIHSKKTA ALQSATPVER VKLQEALSQL DFQWEKVNKM YKDRQGVSER EAALEETHRL LQQFPLDLEK FLAWLTEAET TANVLQDATR KERLLEDSKG VKELMKQWQD LQGEIEAHTD VYHNLDENSQ KILRSLEGSD DAVLLQRRLD NMNFKWSELR KKSLNIRSHL EASSDQWKRL HLSLQELLVW LQLKDDELSR QAPIGGDFPA VQKQNDVHRA FKRELKTKEP VIMSTLETVR IFLTEQPLEG LEKLYQEPRE LPPEERAQNV TRLLRKQAEE VNTEWEKLNL HSADWQRKID ETLERLQELQ EATDELDLKL RQAEVIKGSW QPVGDLLIDS LQDHLEKVKA LRGEIAPLKE NVSHVNDLAR QLTTLGIQLS PYNLSTLEDL NTRWKLLQVA VEDRVRQLHE

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Experimental information

BeamInstrument name: SOLEIL SWING / City: Saint-Aubin / 国: France / Type of source: X-ray synchrotronSynchrotron / Wavelength: 0.1033 Å / Dist. spec. to detc.: 2 mm
DetectorName: Eiger 4M / Pixsize x: 75 mm
Scan
Title: R16-24 del44-54 human dystrophin fragment / Measurement date: Jul 8, 2019 / Cell temperature: 15 °C / Exposure time: 1 sec. / Number of frames: 31 / Unit: 1/A /
MinMax
Q0.0032 0.5253
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 481 /
MinMax
Q0.0118586 0.230662
P(R) point1 481
R0 250
Result
Type of curve: sec /
ExperimentalPorod
MW52 kDa100 kDa
Volume-159 nm3

P(R)GuinierGuinier error
Forward scattering, I00.01822 0.01877 -
Radius of gyration, Rg6.39 nm6.41 nm0.1

MinMax
D-25
Guinier point20 30

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