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- SASDGK2: Interleukin 11/Interleukin 11 receptor alpha complex -

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Open data


ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDGK2
SampleInterleukin 11/Interleukin 11 receptor alpha complex
  • Interleukin-11 receptor subunit alpha (protein), IL11RA, Homo sapiens
  • Interleukin 11, N-terminal truncation (protein), IL11, Homo sapiens
Function / homology
Function and homology information


interleukin-11 receptor binding / interleukin-11 receptor activity / interleukin-11 binding / head development / interleukin-11-mediated signaling pathway / developmental process / IL-6-type cytokine receptor ligand interactions / cytokine activity / growth factor activity / cytokine-mediated signaling pathway ...interleukin-11 receptor binding / interleukin-11 receptor activity / interleukin-11 binding / head development / interleukin-11-mediated signaling pathway / developmental process / IL-6-type cytokine receptor ligand interactions / cytokine activity / growth factor activity / cytokine-mediated signaling pathway / transmembrane signaling receptor activity / cell population proliferation / positive regulation of MAPK cascade / receptor complex / external side of plasma membrane / positive regulation of cell population proliferation / extracellular region / plasma membrane / cytoplasm
Similarity search - Function
Interleukin-11, mammalian / Interleukin-11 / Interleukin 11 / Long hematopoietin receptor, soluble alpha chain, conserved site / Long hematopoietin receptor, soluble alpha chains family signature. / : / Four-helical cytokine-like, core / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III ...Interleukin-11, mammalian / Interleukin-11 / Interleukin 11 / Long hematopoietin receptor, soluble alpha chain, conserved site / Long hematopoietin receptor, soluble alpha chains family signature. / : / Four-helical cytokine-like, core / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
Interleukin 11 / Interleukin-11 receptor subunit alpha
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Riley D. Metcalfe (Bio21 Institute, The University of Melbourne, Melbourne, Australia)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #3567
Type: atomic / Comment: Model generated using RosettaDock server. / Chi-square value: 1.074 / P-value: 0.734138
Model #3568
Type: dummy / Radius of dummy atoms: 2.75 A / Chi-square value: 1.035 / P-value: 0.963479

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Sample

SampleName: Interleukin 11/Interleukin 11 receptor alpha complex / Specimen concentration: 2.2 mg/ml / Entity id: 1803 / 1804
BufferName: 20 mM Tris, 150 mM NaCl, 0.2% sodium azide / pH: 8.5
Entity #1803Name: IL11RA / Type: protein / Description: Interleukin-11 receptor subunit alpha / Formula weight: 32.179 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q14626
Sequence: GSSPCPQAWG PPGVQYGQPG RSVKLCCPGV TAGDPVSWFR DGEPKLLQGP DSGLGHELVL AQADSTDEGT YICQTLDGAL GGTVTLQLGY PPARPVVSCQ AADYENFSCT WSPSQISGLP TRYLTSYRKK TVLGADSQRR SPSTGPWPCP QDPLGAARCV VHGAEFWSQY ...Sequence:
GSSPCPQAWG PPGVQYGQPG RSVKLCCPGV TAGDPVSWFR DGEPKLLQGP DSGLGHELVL AQADSTDEGT YICQTLDGAL GGTVTLQLGY PPARPVVSCQ AADYENFSCT WSPSQISGLP TRYLTSYRKK TVLGADSQRR SPSTGPWPCP QDPLGAARCV VHGAEFWSQY RINVTEVNPL GASTRLLDVS LQSILRPDPP QGLRVESVPG YPRRLRASWT YPASWPSQPH FLLKFRLQYR PAQHPAWSTV EPAGLEEVIT DAVAGLPHAV RVSARDFLDA GTWSTWSPEA WGTPSTGT
Entity #1804Name: IL11 / Type: protein / Description: Interleukin 11, N-terminal truncation / Formula weight: 18.249 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: A8K3F7
Sequence:
GSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

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Experimental information

BeamInstrument name: Australian Synchrotron SAXS/WAXS / City: Melbourne / 国: Australia / Type of source: X-ray synchrotron / Wavelength: 0.1078 Å / Dist. spec. to detc.: 2.539 mm
DetectorName: Dectris/Pilatus3 S 2M / Pixsize x: 172 mm
Scan
Title: Interleukin 11/Interleukin 11 receptor alpha complex / Measurement date: Jun 8, 2019 / Cell temperature: 20 °C / Exposure time: 1 sec. / Number of frames: 6 / Unit: 1/A /
MinMax
Q0.0059 0.5341
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 197 /
MinMax
Q0.00829081 0.163005
P(R) point1 197
R0 102
Result
Type of curve: sec /
ExperimentalPorod
MW50.1 kDa53 kDa
Volume-84 nm3

P(R)GuinierGuinier error
Forward scattering, I00.009356 0.009368 6.4E-5
Radius of gyration, Rg3.34 nm3.307 nm0.037

MinMax
D-10.2
Guinier point4 43

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