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- SASDG95: Phosphorylated resistance to inhibitors of cholinesterase 8 homol... -

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Basic information

Entry
Database: SASBDB / ID: SASDG95
SamplePhosphorylated resistance to inhibitors of cholinesterase 8 homolog A (Ric-8A, 1-491) and G protein complex
  • Resistance to inhibitors of cholinesterase 8 homolog A (protein), Ric-8A, Rattus norvegicus
  • Guanine nucleotide-binding protein G(i) subunit alpha-1 (protein), Gia, Rattus norvegicus
Function / homology
Function and homology information


cell-cell adhesion involved in gastrulation / cell migration involved in gastrulation / Extra-nuclear estrogen signaling / Adenylate cyclase inhibitory pathway / basement membrane organization / vasculature development / Adrenaline,noradrenaline inhibits insulin secretion / ADP signalling through P2Y purinoceptor 12 / GTPase activating protein binding / negative regulation of synaptic transmission ...cell-cell adhesion involved in gastrulation / cell migration involved in gastrulation / Extra-nuclear estrogen signaling / Adenylate cyclase inhibitory pathway / basement membrane organization / vasculature development / Adrenaline,noradrenaline inhibits insulin secretion / ADP signalling through P2Y purinoceptor 12 / GTPase activating protein binding / negative regulation of synaptic transmission / G alpha (i) signalling events / G-protein alpha-subunit binding / positive regulation of protein localization to cell cortex / regulation of cAMP-mediated signaling / D2 dopamine receptor binding / G protein-coupled serotonin receptor binding / regulation of mitotic spindle organization / cellular response to forskolin / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / guanyl-nucleotide exchange factor activity / G protein-coupled receptor binding / G-protein beta/gamma-subunit complex binding / visual learning / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / GDP binding / heterotrimeric G-protein complex / cell cortex / midbody / in utero embryonic development / cell cycle / G protein-coupled receptor signaling pathway / cell division / GTPase activity / centrosome / GTP binding / magnesium ion binding / protein-containing complex / nucleus / plasma membrane / cytoplasm
Similarity search - Function
Synembryn / Guanine nucleotide exchange factor, Ric8 / Guanine nucleotide exchange factor synembryn / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / Armadillo-like helical ...Synembryn / Guanine nucleotide exchange factor, Ric8 / Guanine nucleotide exchange factor synembryn / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / Armadillo-like helical / Armadillo-type fold / P-loop containing nucleoside triphosphate hydrolase
Similarity search - Domain/homology
Synembryn / Guanine nucleotide-binding protein G(i) subunit alpha-1
Similarity search - Component
Biological speciesRattus norvegicus (Norway rat)
Contact author
  • Tung-Chung Mou (University of Montana, Montana, USA)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #3779
Type: dummy / Radius of dummy atoms: 3.25 A / Chi-square value: 0.910 / P-value: 0.257845

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Sample

SampleName: Phosphorylated resistance to inhibitors of cholinesterase 8 homolog A (Ric-8A, 1-491) and G protein complex
Specimen concentration: 5 mg/ml / Entity id: 1891 / 1892
BufferName: 25 mM HEPES, 150 mM NaCl / pH: 8
Entity #1891Name: Ric-8A / Type: protein
Description: Resistance to inhibitors of cholinesterase 8 homolog A
Formula weight: 55.559 / Num. of mol.: 1 / Source: Rattus norvegicus / References: UniProt: B1H241
Sequence: MEPRAVADAL ETGEEDAVTE ALRSFNREHS QSFTFDDAQQ EDRKRLAKLL VSVLEQGLSP KHRVTWLQTI RILSRDRSCL DSFASRQSLH ALACYADIAI SEEPIPQPPD MDVLLESLKC LCNLVLSSPT AQMLAAEARL VVRLAERVGL YRKRSYPHEV QFFDLRLLFL ...Sequence:
MEPRAVADAL ETGEEDAVTE ALRSFNREHS QSFTFDDAQQ EDRKRLAKLL VSVLEQGLSP KHRVTWLQTI RILSRDRSCL DSFASRQSLH ALACYADIAI SEEPIPQPPD MDVLLESLKC LCNLVLSSPT AQMLAAEARL VVRLAERVGL YRKRSYPHEV QFFDLRLLFL LTALRTDVRQ QLFQELHGVR LLTDALELTL GVAPKENPLV ILPAQETERA MEILKVLFNI TYDSVKREVD EEDAALYRYL GTLLRHCVMA DAAGDRTEEF HGHTVNLLGN LPLKCLDVLL ALELHEGSLE FMGVNMDVIN ALLAFLEKRL HQTHRLKECV APVLSVLTEC ARMHRPARKF LKAQVLPPLR DVRTRPEVGD LLRNKLVRLM THLDTDVKRV AAEFLFVLCS ESVPRFIKYT GYGNAAGLLA ARGLMAGGRP EGQYSEDEDT DTEEYREAKA SINPVTGRVE EKPPNPMEGM TEEQKEHEAM KLVNMFDKLS R
Entity #1892Name: Gia / Type: protein
Description: Guanine nucleotide-binding protein G(i) subunit alpha-1
Formula weight: 37.824 / Num. of mol.: 1 / Source: Rattus norvegicus / References: UniProt: P10824
Sequence: REDGEKAARE VKLLLLGAGE SGKSTIVKQM KIIHEAGYSE EECKQYKAVV YSNTIQSIIA IIRAMGRLKI DFGDAARADD ARQLFVLAGA AEEGFMTAEL AGVIKRLWKD SGVQACFNRS REYQLNDSAA YYLNDLDRIA QPNYIPTQQD VLRTRVKTTG IVETHFTFKD ...Sequence:
REDGEKAARE VKLLLLGAGE SGKSTIVKQM KIIHEAGYSE EECKQYKAVV YSNTIQSIIA IIRAMGRLKI DFGDAARADD ARQLFVLAGA AEEGFMTAEL AGVIKRLWKD SGVQACFNRS REYQLNDSAA YYLNDLDRIA QPNYIPTQQD VLRTRVKTTG IVETHFTFKD LHFKMFDVGG QRSERKKWIH CFEGVTAIIF CVALSDYDLV LAEDEEMNRM HESMKLFDSI CNNKWFTDTS IILFLNKKDL FEEKIKKSPL TICYPEYAGS NTYEEAAAYI QCQFEDLNKR KDTKEIYTHF TCATDTKNVQ FVFDAVTDVI IKNNLKDCGL F

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Experimental information

BeamInstrument name: Advanced Photon Source (APS), Argonne National Laboratory BioCAT 18ID
City: Lemont, IL / 国: USA / Type of source: X-ray synchrotron / Wavelength: 0.1033 Å / Dist. spec. to detc.: 3.67 mm
DetectorName: Pilatus3 X 1M / Pixsize x: 0.172 mm
Scan
Title: Phosphorylated resistance to inhibitors of cholinesterase 8 homolog A (Ric-8A, 1-491) and G protein complex
Measurement date: Jul 30, 2019 / Storage temperature: 4 °C / Cell temperature: 20 °C / Exposure time: 0.5 sec. / Number of frames: 1500 / Unit: 1/A /
MinMax
Q0.0043 0.3522
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 1228 /
MinMax
Q0.00425604 0.351957
P(R) point1 1228
R0 115
Result
Type of curve: sec /
ExperimentalPorod
MW92 kDa-
Volume-120 nm3

P(R)GuinierGuinier error
Forward scattering, I00.149 0.1485 0.0001028
Radius of gyration, Rg3.53 nm3.48 nm0.01

MinMax
D-11.5
Guinier point9 114

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