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- SASDG45: Mothers against decapentaplegic homolog 2, S2MH1noE3 -

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Basic information

Entry
Database: SASBDB / ID: SASDG45
SampleMothers against decapentaplegic homolog 2, S2MH1noE3
  • Mothers against decapentaplegic homolog 2 (protein), Homo sapiens
Function / homology
Function and homology information


: / : / : / zygotic specification of dorsal/ventral axis / DNA-binding transcription factor binding => GO:0140297 / regulation of binding / paraxial mesoderm morphogenesis / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer ...: / : / : / zygotic specification of dorsal/ventral axis / DNA-binding transcription factor binding => GO:0140297 / regulation of binding / paraxial mesoderm morphogenesis / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / nodal signaling pathway / SMAD protein complex / endoderm formation / co-SMAD binding / heteromeric SMAD protein complex / secondary palate development / pericardium development / FOXO-mediated transcription of cell cycle genes / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / Transcriptional regulation of pluripotent stem cells / regulation of transforming growth factor beta receptor signaling pathway / embryonic foregut morphogenesis / primary miRNA processing / transforming growth factor beta receptor binding / type I transforming growth factor beta receptor binding / signal transduction involved in regulation of gene expression / activin receptor signaling pathway / Signaling by Activin / SMAD protein signal transduction / positive regulation of BMP signaling pathway / Signaling by NODAL / response to cholesterol / embryonic cranial skeleton morphogenesis / I-SMAD binding / pancreas development / insulin secretion / anterior/posterior pattern specification / ureteric bud development / organ growth / adrenal gland development / protein deubiquitination / SMAD binding / TGF-beta receptor signaling activates SMADs / somatic stem cell population maintenance / R-SMAD binding / transcription factor binding / mesoderm formation / phosphatase binding / anatomical structure morphogenesis / cell fate commitment / cis-regulatory region sequence-specific DNA binding / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / BMP signaling pathway / response to glucose / positive regulation of epithelial to mesenchymal transition / gastrulation / Downregulation of TGF-beta receptor signaling / transforming growth factor beta receptor signaling pathway / post-embryonic development / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / negative regulation of transforming growth factor beta receptor signaling pathway / lung development / wound healing / tau protein binding / disordered domain specific binding / double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / in utero embryonic development / transcription regulator complex / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / Ub-specific processing proteases / intracellular signal transduction / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / chromatin binding / positive regulation of gene expression / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / nucleus / metal ion binding / cytoplasm / cytosol
Similarity search - Function
MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain ...MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / SMAD/FHA domain superfamily
Similarity search - Domain/homology
Mothers against decapentaplegic homolog 2
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Tiago Lopes (IRB, Institute for Research in Biomedicine in Barcelona (IRB), Barcelona, Spain)

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Structure visualization

Downloads & links

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Models

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Sample

SampleName: Mothers against decapentaplegic homolog 2, S2MH1noE3 / Specimen concentration: 1.30-6.80
BufferName: 20 mM Tris 150 mM NaCl / pH: 7.2
Entity #1877Type: protein / Description: Mothers against decapentaplegic homolog 2 / Formula weight: 15.666 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q15796-2
Sequence:
GSSPVVKRLL GWKKSAGGSG GAGGGEQNGQ EEKWSEKAVK SLVKKLKKTG RLDELEKAIT TQNMNTKCVT IPRSLDGRLQ VSHRKGLPHV IYCRLWRWPD LHSHHELKAI ENCEYAFNLK KDEVCVNPYH YQRVETPSS

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Experimental information

BeamInstrument name: ESRF BM29 / City: Grenoble / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.099 Å
DetectorName: Pilatus 1M / Type: Dectris / Pixsize x: 172 mm
Scan
Title: Mothers against decapentaplegic homolog 2, S2MH1noE3 / Measurement date: Jul 2, 2015 / Storage temperature: 10 °C / Cell temperature: 10 °C / Unit: 1/nm /
MinMax
Q0.0562 4.9336
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 977 /
MinMax
Q0.131457 4.72194
P(R) point1 977
R0 6.6
Result
Type of curve: merged /
ExperimentalPorod
MW18.08 kDa19 kDa
Volume-30.74 nm3

P(R)GuinierGuinier error
Forward scattering, I017.04 16.9 0.017
Radius of gyration, Rg1.76 nm1.69 nm0.01

MinMax
D-6.6
Guinier point17 151

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