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- SASDG22: RuvB-like 1 and 2 dodecamer (His-RuvBL1/RuvBL2) (RuvB-like 1 + Ru... -

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ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDG22
SampleRuvB-like 1 and 2 dodecamer (His-RuvBL1/RuvBL2)
  • RuvB-like 1 (protein), Homo sapiens
  • RuvB-like 2 (protein), Homo sapiens
Function / homology
Function and homology information


promoter-enhancer loop anchoring activity / telomerase RNA localization to Cajal body / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / establishment of protein localization to chromatin / R2TP complex / dynein axonemal particle / Swr1 complex / RPAP3/R2TP/prefoldin-like complex / Ino80 complex ...promoter-enhancer loop anchoring activity / telomerase RNA localization to Cajal body / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / establishment of protein localization to chromatin / R2TP complex / dynein axonemal particle / Swr1 complex / RPAP3/R2TP/prefoldin-like complex / Ino80 complex / regulation of double-strand break repair / box C/D snoRNP assembly / protein folding chaperone complex / single-stranded 3'-5' DNA helicase activity / double-stranded DNA helicase activity / forked DNA-dependent helicase activity / regulation of chromosome organization / NuA4 histone acetyltransferase complex / regulation of DNA replication / TFIID-class transcription factor complex binding / four-way junction helicase activity / MLL1 complex / regulation of embryonic development / Telomere Extension By Telomerase / positive regulation of double-strand break repair via homologous recombination / RNA polymerase II core promoter sequence-specific DNA binding / regulation of DNA repair / Deposition of new CENPA-containing nucleosomes at the centromere / telomere maintenance / DNA helicase activity / positive regulation of DNA repair / TBP-class protein binding / DNA Damage Recognition in GG-NER / cellular response to estradiol stimulus / chromatin DNA binding / negative regulation of canonical Wnt signaling pathway / Formation of the beta-catenin:TCF transactivating complex / euchromatin / ADP binding / beta-catenin binding / nuclear matrix / UCH proteinases / transcription corepressor activity / cellular response to UV / positive regulation of canonical Wnt signaling pathway / unfolded protein binding / nucleosome / protein folding / HATs acetylate histones / ATPase binding / spermatogenesis / regulation of apoptotic process / DNA recombination / DNA helicase / transcription coactivator activity / Ub-specific processing proteases / regulation of cell cycle / protein stabilization / nuclear speck / ciliary basal body / chromatin remodeling / cadherin binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / ribonucleoprotein complex / cell division / DNA repair / centrosome / regulation of transcription by RNA polymerase II / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / ATP hydrolysis activity / extracellular exosome / nucleoplasm / ATP binding / identical protein binding / nucleus / membrane / cytosol / cytoplasm
Similarity search - Function
RuvB-like / RuvB-like, AAA-lid domain / RuvBL1/2, DNA/RNA binding domain / TIP49 P-loop domain / TIP49 AAA-lid domain / TIP49, P-loop domain / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase
Similarity search - Domain/homology
RuvB-like 2 / RuvB-like 1
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Raphael Dos Santos Morais (University of Lorraine, France)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #3561
Type: dummy / Software: (dammif (r10552)) / Radius of dummy atoms: 3.40 A / Chi-square value: 1.158 / P-value: 0.052487

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Sample

SampleName: RuvB-like 1 and 2 dodecamer (His-RuvBL1/RuvBL2) / Specimen concentration: 8.45 mg/ml / Entity id: 1608 / 1609
BufferName: 20 mM HEPES, 150 mM NaCl, 1% glycerol, 5 mM TCEP / pH: 7.5
Entity #1608Type: protein / Description: RuvB-like 1 / Formula weight: 51.759 / Num. of mol.: 6 / Source: Homo sapiens / References: UniProt: Q9Y265
Sequence: MVHHHHHHLV PRGSKIEEVK STTKTQRIAS HSHVKGLGLD ESGLAKQAAS GLVGQENARE ACGVIVELIK SKKMAGRAVL LAGPPGTGKT ALALAIAQEL GSKVPFCPMV GSEVYSTEIK KTEVLMENFR RAIGLRIKET KEVYEGEVTE LTPCETENPM GGYGKTISHV ...Sequence:
MVHHHHHHLV PRGSKIEEVK STTKTQRIAS HSHVKGLGLD ESGLAKQAAS GLVGQENARE ACGVIVELIK SKKMAGRAVL LAGPPGTGKT ALALAIAQEL GSKVPFCPMV GSEVYSTEIK KTEVLMENFR RAIGLRIKET KEVYEGEVTE LTPCETENPM GGYGKTISHV IIGLKTAKGT KQLKLDPSIF ESLQKERVEA GDVIYIEANS GAVKRQGRCD TYATEFDLEA EEYVPLPKGD VHKKKEIIQD VTLHDLDVAN ARPQGGQDIL SMMGQLMKPK KTEITDKLRG EINKVVNKYI DQGIAELVPG VLFVDEVHML DIECFTYLHR ALESSIAPIV IFASNRGNCV IRGTEDITSP HGIPLDLLDR VMIIRTMLYT PQEMKQIIKI RAQTEGINIS EEALNHLGEI GTKTTLRYSV QLLTPANLLA KINGKDSIEK EHVEEISELF YDAKSSAKIL ADQQDKYMK
Entity #1609Type: protein / Description: RuvB-like 2 / Formula weight: 51.886 / Num. of mol.: 6 / Source: Homo sapiens / References: UniProt: Q9Y230
Sequence: MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET ...Sequence:
MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTSLEVLFQ

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Experimental information

BeamInstrument name: SOLEIL SWING / City: Saint-Aubin / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.1033 Å / Dist. spec. to detc.: 2 mm
DetectorName: Eiger 4M / Pixsize x: 75 mm
Scan
Title: RuvB-like 1 and 2 dodecamer (His-RuvBL1/RuvBL2) / Measurement date: Mar 3, 2019 / Cell temperature: 15 °C / Exposure time: 1 sec. / Number of frames: 17 / Unit: 1/A /
MinMax
Q0.0041 0.5786
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 453 /
MinMax
Q0.00729749 0.213353
P(R) point1 453
R0 234
Result
Type of curve: sec /
ExperimentalPorod
MW761 kDa-
Volume-1550 nm3

P(R)GuinierGuinier error
Forward scattering, I00.3017 0.3021 -
Radius of gyration, Rg6.26 nm6.28 nm0.005

MinMax
D-23.4
Guinier point8 37

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