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Yorodumi- SASDFY4: R4-15 human dystrophin fragment (Human dystrophin central domain ... -
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-Basic information
Entry | Database: SASBDB / ID: SASDFY4 |
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Sample | R4-15 human dystrophin fragment
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Function / homology | Function and homology information regulation of muscle system process / regulation of cellular response to growth factor stimulus / regulation of skeletal muscle contraction / syntrophin complex / synaptic signaling / cardiac muscle cell action potential / regulation of voltage-gated calcium channel activity / negative regulation of peptidyl-cysteine S-nitrosylation / positive regulation of sodium ion transmembrane transporter activity / dystrophin-associated glycoprotein complex ...regulation of muscle system process / regulation of cellular response to growth factor stimulus / regulation of skeletal muscle contraction / syntrophin complex / synaptic signaling / cardiac muscle cell action potential / regulation of voltage-gated calcium channel activity / negative regulation of peptidyl-cysteine S-nitrosylation / positive regulation of sodium ion transmembrane transporter activity / dystrophin-associated glycoprotein complex / regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / peptide biosynthetic process / cell-substrate junction / motile cilium assembly / dystroglycan binding / vinculin binding / muscle cell development / costamere / neuron projection terminus / Striated Muscle Contraction / filopodium membrane / muscle organ development / structural constituent of muscle / muscle cell cellular homeostasis / myosin binding / maintenance of blood-brain barrier / nitric-oxide synthase binding / negative regulation of peptidyl-serine phosphorylation / Non-integrin membrane-ECM interactions / neuron development / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / cardiac muscle contraction / skeletal muscle tissue development / regulation of ryanodine-sensitive calcium-release channel activity / response to muscle stretch / positive regulation of neuron differentiation / regulation of heart rate / filopodium / protein localization / structural constituent of cytoskeleton / sarcolemma / positive regulation of neuron projection development / Z disc / actin binding / protein-containing complex assembly / postsynaptic membrane / cytoskeleton / membrane raft / synapse / cell surface / protein-containing complex / zinc ion binding / nucleus / plasma membrane / cytosol Similarity search - Function |
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-Structure visualization
-Downloads & links
-Data source
SASBDB page | SASDFY4 |
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-Related structure data
Similar structure data | Similarity search - Function & homologyF&H Search |
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-External links
Related items in Molecule of the Month |
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-Models
-Sample
Sample | Name: R4-15 human dystrophin fragment |
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Buffer | Name: NaP 20 mM, NaCl 300 mM, EDTA 1 mM, Glycérol 2% / pH: 7.5 |
Entity #1556 | Type: protein / Description: Human dystrophin central domain R4-15 fragment / Formula weight: 150.486 / Num. of mol.: 1 / References: UniProt: P11532 Sequence: MSYYHHHHHH DYDIPTTENL YFOGAMGRSL VPRGSSEIRK RLDVDITELH SWITRSEAVL QSPEFAIFRK EGNFSDLKEK VNAIEREKAE KFRKLQDASR SAQALVEQMV NEGVNADSIK QASEQLNSRW IEFCQLLSER LNWLEYQNNI IAFYNQLQQL EQMTTTAENW ...Sequence: MSYYHHHHHH DYDIPTTENL YFOGAMGRSL VPRGSSEIRK RLDVDITELH SWITRSEAVL QSPEFAIFRK EGNFSDLKEK VNAIEREKAE KFRKLQDASR SAQALVEQMV NEGVNADSIK QASEQLNSRW IEFCQLLSER LNWLEYQNNI IAFYNQLQQL EQMTTTAENW LKIQPTTPSE PTAIKSQLKI CKDEVNRLSG LQPQIERLKI QSIALKEKGQ GPMFLDADFV AFTNHFKQVF SDVQAREKEL QTIFDTLPPM RYQETMSAIR TWVQQSETKL SIPQLSVTDY EIMEQRLGEL QALQSSLQEQ QSGLYYLSTT VKEMSKKAPS EISRKYQSEF EEIEGRWKKL SSQLVEHCQK LEEQMNKLRK IQNHIQTLKK WMAEVDVFLK EEWPALGDSE ILKKQLKQCR LLVSDIQTIQ PSLNSVNEGG QKIKNEAEPE FASRLETELK ELNTQWDHMC QQVYARKEAL KGGLEKTVSL QKDLSEMHEW MTQAEEEYLE RDFEYKTPDE LQKAVEEMKR AKEEAQQKEA KVKLLTESVN SVIAQAPPVA QEALKKELET LTTNYQWLCT RLNGKCKTLE EVWACWHELL SYLEKANKWL NEVEFKLKTT ENIPGGAEEI SEVLDSLENL MRHSEDNPNQ IRILAQTLTD GGVMDELINE ELETFNSRWR ELHEEAVRRQ KLLEQSIQSA QETEKSLHLI QESLTFIDKQ LAAYIADKVD AAQMPQEAQK IQSDLTSHEI SLEEMKKHNQ GKEAAQRVLS QIDVAQKKLQ DVSMKFRLFQ KPANFELRLQ ESKMILDEVK MHLPALETKS VEQEVVQSQL NHCVNLYKSL SEVKSEVEMV IKTGRQIVQK KQTENPKELD ERVTALKLHY NELGAKVTER KQQLEKCLKL SRKMRKEMNV LTEWLAATDM ELTKRSAVEG MPSNLDSEVA WGKATQKEIE KQKVHLKSIT EVGEALKTVL GKKETLVEDK LSLLNSNWIA VTSRAEEWLN LLLEYQKHME TFDQNVDHIT KWIIQADTLL DESEKKKPQQ KEDVLKRLKA ELNDIRPKVD STRDQAANLM ANRGDHCRKL VEPQISELNH RFAAISHRIK TGKASIPLKE LEQFNSDIQK LLEPLEAEIQ QGVNLKEEDF NKDMNEDNEG TVKELLQRGD NLQQRITDER KREEIKIKQQ LLQTKHNALK DLRSQRRKKA LEISHQWYQY KRQADDLLKC LDDIEKKLAS LPEPRDERKI KEIDRELQKK KEELNAVRRQ AEGLSEDGAA MAVEPTQIQL SKRWREIESK FAQFRRLNFA Q |
-Experimental information
Beam | Instrument name: SOLEIL SWING / City: Saint-Aubin / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.1033 Å / Dist. spec. to detc.: 2 mm | ||||||||||||
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Detector | Name: AVIEX PCCD170170 / Type: CCD | ||||||||||||
Scan | Title: R4-15 human dystrophin fragment / Measurement date: May 26, 2016 / Cell temperature: 20 °C / Exposure time: 1 sec. / Number of frames: 21 / Unit: 1/A /
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Distance distribution function P(R) | Sofotware P(R): GNOM 4.6 / Number of points: 444 /
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Result | Experimental MW: 150 kDa / D max: 47.5 / Type of curve: sec Comments: SEC-SAXS was performed at 20°C using the following parameters: Column: BioSEC5-500Å (4.6 mm id * 300 mm); Flow rate: 0.3 mL/min; Sample injection concentration: 4.4 mg/mL; Injection ...Comments: SEC-SAXS was performed at 20°C using the following parameters: Column: BioSEC5-500Å (4.6 mm id * 300 mm); Flow rate: 0.3 mL/min; Sample injection concentration: 4.4 mg/mL; Injection volume: 50μL. The data were collected through the SEC peak of the protein as a series of 21 x 1 second exposures. The experimental molecular weight was determined from SEC-MALS (150 kDa).
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