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- SASDFS7: Talin-1 head amino acids 1-405(Δ139-168) (Talin-1 (Δ139-168), hum... -

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Basic information

Entry
Database: SASBDB / ID: SASDFS7
SampleTalin-1 head amino acids 1-405(Δ139-168)
  • Talin-1 (Δ139-168), human (protein), TLN1, Homo sapiens
Function / homology
Function and homology information


LIM domain binding / XBP1(S) activates chaperone genes / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / vinculin binding / integrin activation / cell-substrate junction assembly / cell-cell junction assembly / cortical actin cytoskeleton organization / regulation of focal adhesion assembly / p130Cas linkage to MAPK signaling for integrins ...LIM domain binding / XBP1(S) activates chaperone genes / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / vinculin binding / integrin activation / cell-substrate junction assembly / cell-cell junction assembly / cortical actin cytoskeleton organization / regulation of focal adhesion assembly / p130Cas linkage to MAPK signaling for integrins / phosphatidylserine binding / GRB2:SOS provides linkage to MAPK signaling for Integrins / Smooth Muscle Contraction / ruffle / Integrin signaling / phosphatidylinositol binding / integrin-mediated signaling pathway / adherens junction / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / structural constituent of cytoskeleton / platelet aggregation / cell-cell adhesion / ruffle membrane / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / actin filament binding / integrin binding / Platelet degranulation / cytoskeleton / cadherin binding / focal adhesion / cell surface / extracellular exosome / extracellular region / plasma membrane / cytosol
Similarity search - Function
Vinculin-binding site-containing domain / Talin, central / Talin, central domain superfamily / Talin-1/2, rod-segment / : / : / : / Vinculin Binding Site / Talin, middle domain / Talin, R4 domain ...Vinculin-binding site-containing domain / Talin, central / Talin, central domain superfamily / Talin-1/2, rod-segment / : / : / : / Vinculin Binding Site / Talin, middle domain / Talin, R4 domain / Talin 1-like, rod segment domain / Talin IBS2B domain / Talin, N-terminal F0 domain / N-terminal or F0 domain of Talin-head FERM / I/LWEQ domain / I/LWEQ domain superfamily / I/LWEQ domain / I/LWEQ domain profile. / I/LWEQ domain / Phosphotyrosine-binding domain / IRS-type PTB domain / PTB domain (IRS-1 type) / Alpha-catenin/vinculin-like superfamily / FERM domain signature 1. / FERM conserved site / FERM domain signature 2. / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / PH-like domain superfamily / Ubiquitin-like domain superfamily
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
Contact author
  • Sampo Kukkurainen (Tampere University, Tampere, Finland)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #3064
Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.642 / P-value: 0.823578
Model #3065
Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.642 / P-value: 0.823578
Model #3066
Type: mix / Software: (2.1 online) / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.642 / P-value: 0.823578

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Sample

SampleName: Talin-1 head amino acids 1-405(Δ139-168) / Specimen concentration: 13.6 mg/ml
BufferName: 50 mM sodium phosphate, 150mM NaCl / pH: 7.2
Entity #1684Name: TLN1 / Type: protein / Description: Talin-1 (Δ139-168), human / Formula weight: 47.667 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q9Y490
Sequence: GGSHHHHHHG MASMTGGQQM GRDLYDDDDK DRWIRPRAMV ALSLKISIGN VVKTMQFEPS TMVYDACRII RERIPEAPAG PPSDFGLFLS DDDPKKGIWL EAGKALDYYM LRNGDTMEYR KKQRPLKIRM LDGTVKTIMV DDSKTVTDML MTICARIGIT NHDEYSLVRE ...Sequence:
GGSHHHHHHG MASMTGGQQM GRDLYDDDDK DRWIRPRAMV ALSLKISIGN VVKTMQFEPS TMVYDACRII RERIPEAPAG PPSDFGLFLS DDDPKKGIWL EAGKALDYYM LRNGDTMEYR KKQRPLKIRM LDGTVKTIMV DDSKTVTDML MTICARIGIT NHDEYSLVRE LMEEKKDELN WLDHGRTLRE QGVEEHETLL LRRKFFYSDQ NVDSRDPVQL NLLYVQARDD ILNGSHPVSF DKACEFAGFQ CQIQFGPHNE QKHKAGFLDL KDFLPKEYVK QKGERKIFQA HKNCGQMSEI EAKVRYVKLA RSLKTYGVSF FLVKEKMKGK NKLVPRLLGI TKECVMRVDE KTKEVIQEWN LTNIKRWAAS PKSFTLDFGD YQDGYYSVQT TEGEQIAQLI AGYIDIILKK KKS

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Experimental information

BeamInstrument name: PETRA III EMBL P12 / City: Hamburg / 国: Germany / Type of source: X-ray synchrotron / Wavelength: 0.12399 Å / Dist. spec. to detc.: 3 mm
DetectorName: Pilatus 2M
Scan
Title: Talin-1 head amino acids 1-405(Δ139-168) / Measurement date: Sep 24, 2015 / Storage temperature: 4 °C / Cell temperature: 10 °C / Exposure time: 0.995 sec. / Number of frames: 20 / Unit: 1/nm /
MinMax
Q0.0252 4.8124
Distance distribution function P(R)
Sofotware P(R): GNOM 4.5a / Number of points: 409 /
MinMax
Q0.1455 4.458
P(R) point1 409
R0 13.25
Result
Type of curve: sec
ExperimentalStandardPorod
MW47.666 kDa63.235 kDa48 kDa
Volume--77 nm3

P(R)GuinierGuinier error
Forward scattering, I03916 3836.63 15.23
Radius of gyration, Rg3.48 nm3.28 nm0.08

MinMax
D-13.25
Guinier point45 141

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