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- SASDFH5: DPCD His-RuvBl1/RuvBl2 hexamer complex (Protein DPCD + RuvB-like ... -

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Open data


ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDFH5
SampleDPCD His-RuvBl1/RuvBl2 hexamer complex
  • Protein DPCD (protein), Homo sapiens
  • RuvB-like 1 (protein), Homo sapiens
  • RuvB-like 2 (protein), Homo sapiens
Function / homology
Function and homology information


third ventricle development / lateral ventricle development / epithelial cilium movement involved in extracellular fluid movement / promoter-enhancer loop anchoring activity / telomerase RNA localization to Cajal body / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / establishment of protein localization to chromatin / R2TP complex / dynein axonemal particle ...third ventricle development / lateral ventricle development / epithelial cilium movement involved in extracellular fluid movement / promoter-enhancer loop anchoring activity / telomerase RNA localization to Cajal body / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / establishment of protein localization to chromatin / R2TP complex / dynein axonemal particle / Swr1 complex / RPAP3/R2TP/prefoldin-like complex / flagellated sperm motility / Ino80 complex / regulation of double-strand break repair / determination of left/right symmetry / box C/D snoRNP assembly / protein folding chaperone complex / regulation of chromosome organization / NuA4 histone acetyltransferase complex / regulation of DNA replication / TFIID-class transcription factor complex binding / MLL1 complex / regulation of embryonic development / Telomere Extension By Telomerase / positive regulation of double-strand break repair via homologous recombination / RNA polymerase II core promoter sequence-specific DNA binding / regulation of DNA repair / Deposition of new CENPA-containing nucleosomes at the centromere / telomere maintenance / DNA helicase activity / positive regulation of DNA repair / TBP-class protein binding / cellular response to estradiol stimulus / establishment of localization in cell / negative regulation of canonical Wnt signaling pathway / Formation of the beta-catenin:TCF transactivating complex / euchromatin / DNA Damage Recognition in GG-NER / ADP binding / beta-catenin binding / chromatin DNA binding / nuclear matrix / cellular response to UV / transcription corepressor activity / UCH proteinases / positive regulation of canonical Wnt signaling pathway / unfolded protein binding / nucleosome / protein folding / HATs acetylate histones / ATPase binding / single-stranded 3'-5' DNA helicase activity / double-stranded DNA helicase activity / forked DNA-dependent helicase activity / four-way junction helicase activity / spermatogenesis / regulation of apoptotic process / DNA recombination / DNA helicase / transcription coactivator activity / regulation of cell cycle / Ub-specific processing proteases / protein stabilization / nuclear speck / ciliary basal body / cadherin binding / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / ribonucleoprotein complex / cell division / DNA repair / centrosome / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / ATP hydrolysis activity / extracellular exosome / extracellular region / nucleoplasm / ATP binding / identical protein binding / nucleus / membrane / cytosol / cytoplasm
Similarity search - Function
Protein DPCD / DPCD protein family / RuvB-like / RuvB-like, AAA-lid domain / RuvBL1/2, DNA/RNA binding domain / TIP49 P-loop domain / TIP49 AAA-lid domain / TIP49, P-loop domain / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase
Similarity search - Domain/homology
Protein DPCD / RuvB-like 2 / RuvB-like 1
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Raphael Dos Santos Morais (University of Lorraine)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #2935
Type: dummy / Radius of dummy atoms: 2.90 A / Chi-square value: 1.507 / P-value: 0.347397

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Sample

SampleName: DPCD His-RuvBl1/RuvBl2 hexamer complex / Specimen concentration: 4 mg/ml / Entity id: 1607 / 1611 / 1612
BufferName: HEPES 20 mM, NaCl 150 mM, Glycerol 1%, TCEP 5 mM / pH: 7.5
Entity #1607Type: protein / Description: Protein DPCD / Formula weight: 23.505 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q9BVM2
Sequence: GPHMAVTGWL ESLRTAQKTA LLQDGRRKVH YLFPDGKEMA EEYDEKTSEL LVRKWRVKSA LGAMGQWQLE VGDPAPLGAG NLGPELIKES NANPIFMRKD TKMSFQWRIR NLPYPKDVYS VSVDQKERCI IVRTTNKKYY KKFSIPDLDR HQLPLDDASL SFAHANCTLI ...Sequence:
GPHMAVTGWL ESLRTAQKTA LLQDGRRKVH YLFPDGKEMA EEYDEKTSEL LVRKWRVKSA LGAMGQWQLE VGDPAPLGAG NLGPELIKES NANPIFMRKD TKMSFQWRIR NLPYPKDVYS VSVDQKERCI IVRTTNKKYY KKFSIPDLDR HQLPLDDASL SFAHANCTLI ISYQKPKEVV VAESELQKEL KKVKTAHSND GDCKTQ
Entity #1611Type: protein / Description: RuvB-like 1 / Formula weight: 51.759 / Num. of mol.: 3 / Source: Homo sapiens / References: UniProt: Q9Y265
Sequence: MVHHHHHHLV PRGSKIEEVK STTKTQRIAS HSHVKGLGLD ESGLAKQAAS GLVGQENARE ACGVIVELIK SKKMAGRAVL LAGPPGTGKT ALALAIAQEL GSKVPFCPMV GSEVYSTEIK KTEVLMENFR RAIGLRIKET KEVYEGEVTE LTPCETENPM GGYGKTISHV ...Sequence:
MVHHHHHHLV PRGSKIEEVK STTKTQRIAS HSHVKGLGLD ESGLAKQAAS GLVGQENARE ACGVIVELIK SKKMAGRAVL LAGPPGTGKT ALALAIAQEL GSKVPFCPMV GSEVYSTEIK KTEVLMENFR RAIGLRIKET KEVYEGEVTE LTPCETENPM GGYGKTISHV IIGLKTAKGT KQLKLDPSIF ESLQKERVEA GDVIYIEANS GAVKRQGRCD TYATEFDLEA EEYVPLPKGD VHKKKEIIQD VTLHDLDVAN ARPQGGQDIL SMMGQLMKPK KTEITDKLRG EINKVVNKYI DQGIAELVPG VLFVDEVHML DIECFTYLHR ALESSIAPIV IFASNRGNCV IRGTEDITSP HGIPLDLLDR VMIIRTMLYT PQEMKQIIKI RAQTEGINIS EEALNHLGEI GTKTTLRYSV QLLTPANLLA KINGKDSIEK EHVEEISELF YDAKSSAKIL ADQQDKYMK
Entity #1612Type: protein / Description: RuvB-like 2 / Formula weight: 51.886 / Num. of mol.: 3 / Source: Homo sapiens / References: UniProt: Q9Y230
Sequence: MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET ...Sequence:
MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTSLEVLFQ

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Experimental information

BeamInstrument name: SOLEIL SWING / City: Saint-Aubin / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.1033 Å / Dist. spec. to detc.: 2 mm
DetectorName: Eiger 4M / Pixsize x: 75 mm
Scan
Title: DPCD His-RuvBl1/RuvBl2 hexamer complex / Measurement date: Mar 21, 2019 / Cell temperature: 15 °C / Exposure time: 1 sec. / Number of frames: 41 / Unit: 1/A /
MinMax
Q0.0041 0.5782
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 442 /
MinMax
Q0.00775358 0.208798
P(R) point1 442
R0 159
Result
Type of curve: sec
Comments: The experimental molecular weight was determined from SEC-RALS/LALS experiment (370 kDa).
ExperimentalPorod
MW370 kDa-
Volume-856 nm3

P(R)GuinierGuinier error
Forward scattering, I00.09084 0.09066 5.0E-5
Radius of gyration, Rg5.33 nm5.39 nm0.04

MinMax
D-15.9
Guinier point5 44

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