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- SASDF45: Leukocidin/Integrin alpha-M complex (LukGH-huCD11b-I) in the pres... -

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Entry
Database: SASBDB / ID: SASDF45
SampleLeukocidin/Integrin alpha-M complex (LukGH-huCD11b-I) in the presence of a neutralizing antibody Fab fragment
  • Leukocidin G (protein), LukG, Staphylococcus aureus
  • Leukocidin H (protein), LukH, Staphylococcus aureus
  • LukGH neutralizing antibody (protein), Fab, Homo sapiens
  • Integrin alpha-M (protein), huCD11b-I, Homo sapiens
Biological speciesStaphylococcus aureus (bacteria)
Homo sapiens (human)

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Structure visualization

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Models

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Sample

SampleName: Leukocidin/Integrin alpha-M complex (LukGH-huCD11b-I) in the presence of a neutralizing antibody Fab fragment
Specimen concentration: 4.2 mg/ml / Entity id: 1577 / 1578 / 1579 / 1581
BufferName: 20 mM Hepes, 300 mM NaCl, 1 mM MgCl2 / pH: 7.5
Entity #1577Name: LukG / Type: protein / Description: Leukocidin G / Formula weight: 35.573 / Num. of mol.: 1 / Source: Staphylococcus aureus
Sequence: KINSEIKQVS EKNLDGDTKM YTRTATTSDS QKNITQSLQF NFLTEPNYDK ETVFIKAKGT IGSGLRILDP NGYWNSTLRW PGSYSVSIQN VDDNNNTNVT DFAPKNQDES REVKYTYGYK TGGDFSINRG GLTGNITKES NYSETISYQQ PSYRTLLDQS TSHKGVGWKV ...Sequence:
KINSEIKQVS EKNLDGDTKM YTRTATTSDS QKNITQSLQF NFLTEPNYDK ETVFIKAKGT IGSGLRILDP NGYWNSTLRW PGSYSVSIQN VDDNNNTNVT DFAPKNQDES REVKYTYGYK TGGDFSINRG GLTGNITKES NYSETISYQQ PSYRTLLDQS TSHKGVGWKV EAHLINNMGH DHTRQLTNDS DNRTKSEIFS LTRNGNLWAK DNFTPKDKMP VTVSEGFNPE FLAVMSHDKK DKGKSQFVVH YKRSMDEFKI DWNRHGFWGY WSGENHVDKK EEKLSALYEV DWKTHNVKFV KVLNDNEKK
Entity #1578Name: LukH / Type: protein / Description: Leukocidin H / Formula weight: 37.619 / Num. of mol.: 1 / Source: Staphylococcus aureus
Sequence: NSAHKDSQDQ NKKEHVDKSQ QKDKRNVTNK DKNSTAPDDI GKNGKITKRT ETVYDEKTNI LQNLQFDFID DPTYDKNVLL VKKQGSIHSN LKFESHKEEK NSNWLKYPSE YHVDFQVKRN RKTEILDQLP KNKISTAKVD STFSYSSGGK FDSTKGIGRT SSNSYSKTIS ...Sequence:
NSAHKDSQDQ NKKEHVDKSQ QKDKRNVTNK DKNSTAPDDI GKNGKITKRT ETVYDEKTNI LQNLQFDFID DPTYDKNVLL VKKQGSIHSN LKFESHKEEK NSNWLKYPSE YHVDFQVKRN RKTEILDQLP KNKISTAKVD STFSYSSGGK FDSTKGIGRT SSNSYSKTIS YNQQNYDTIA SGKNNNWHVH WSVIANDLKY GGEVKNRNDE LLFYRNTRIA TVENPELSFA SKYRYPALVR SGFNPEFLTY LSNEKSNEKT QFEVTYTRNQ DILKNRPGIH YAPPILEKNK DGQRLIVTYE VDWKNKTVKV VDKYSDDNKP YKEG
Entity #1579Name: Fab / Type: protein / Description: LukGH neutralizing antibody / Formula weight: 47.441 / Num. of mol.: 1 / Source: Homo sapiens
Sequence: ELQLQESGPG LVKPSETLSL TCTVSGGSIS SGSYYWDWIR QPPGKGLEWI GNIYKSGSTY YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE RGMHYMDVWG KGTTVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH ...Sequence:
ELQLQESGPG LVKPSETLSL TCTVSGGSIS SGSYYWDWIR QPPGKGLEWI GNIYKSGSTY YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE RGMHYMDVWG KGTTVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTDIQ MTQSPSSLSA SVGDRVTITC RASQSINSYL NWYQQKPGKA PKLLIYAASS LQSGVPSRFS GSGSGTDFTL TISSLQPEDF ATYYCQQQFD PPFTFGGGTK VEIKRTVAAP SVFIFPPSDE QLKSGTASVV CLLNNFYPRE AKVQWKVDNA LQSGNSQESV TEQDSKDSTY SLSSTLTLSK ADYEKHKVYA CEVTHQGLSS PVTKSFNRGE C
Entity #1581Name: huCD11b-I / Type: protein / Description: Integrin alpha-M / Formula weight: 22.261 / Num. of mol.: 1 / Source: Homo sapiens
Sequence: GCPQEDSDIA FLIDGSGSII PHDFRRMKEF VSTVMEQLKK SKTLFSLMQY SEEFRIHFTF KEFQNNPNPR SLVKPITQLL GRTHTATGIR KVVRELFNIT NGARKNAFKI LVVITDGEKF GDPLGYEDVI PEADREGVIR YVIGVGDAFR SEKSRQELNT IASKPPRDHV ...Sequence:
GCPQEDSDIA FLIDGSGSII PHDFRRMKEF VSTVMEQLKK SKTLFSLMQY SEEFRIHFTF KEFQNNPNPR SLVKPITQLL GRTHTATGIR KVVRELFNIT NGARKNAFKI LVVITDGEKF GDPLGYEDVI PEADREGVIR YVIGVGDAFR SEKSRQELNT IASKPPRDHV FQVNNFEALK TIQNQLREKI FAIEG

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Experimental information

BeamInstrument name: PETRA III EMBL P12 / City: Hamburg / 国: Germany / Type of source: X-ray synchrotron / Wavelength: 0.12 Å / Dist. spec. to detc.: 3.1 mm
DetectorName: Pilatus 2M
ScanTitle: Leukocidin/Integrin alpha-M complex (LukGH-huCD11b-I) in the presence of a neutralizing antibody Fab fragment
Measurement date: Sep 17, 2017 / Storage temperature: 15 °C / Cell temperature: 10 °C / Exposure time: 0.045 sec. / Number of frames: 20 / Unit: 1/nm /
MinMax
Q0.0364 2.7286
ResultType of curve: single_conc
ExperimentalStandardStandard errorPorod
MW146 kDa125 kDa15 -
Volume---178 nm3

P(R)P(R) errorGuinierGuinier error
Forward scattering, I05046 13 4980.81 11
Radius of gyration, Rg5.212 nm0.02 4.95 nm0.14

MinMax
D-18
Guinier point1 94

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