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- SASDF42: Human serum albumin in complex with somapacitan (Human serum albu... -

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Basic information

Entry
Database: SASBDB / ID: SASDF42
SampleHuman serum albumin in complex with somapacitan
  • Human serum albumin (protein), HSA, Homo sapiens
  • somapacitan (protein), Homo sapiens
Function / homology
Function and homology information


growth hormone activity / growth hormone receptor complex / bone maturation / prolactin receptor binding / positive regulation of growth / animal organ development / positive regulation of activation of Janus kinase activity / cellular response to calcium ion starvation / positive regulation of multicellular organism growth / exogenous protein binding ...growth hormone activity / growth hormone receptor complex / bone maturation / prolactin receptor binding / positive regulation of growth / animal organ development / positive regulation of activation of Janus kinase activity / cellular response to calcium ion starvation / positive regulation of multicellular organism growth / exogenous protein binding / Ciprofloxacin ADME / positive regulation of glucose transmembrane transport / enterobactin binding / Heme biosynthesis / positive regulation of insulin-like growth factor receptor signaling pathway / growth hormone receptor binding / HDL remodeling / negative regulation of mitochondrial depolarization / Prednisone ADME / growth hormone receptor signaling pathway / Heme degradation / Aspirin ADME / Prolactin receptor signaling / antioxidant activity / cell surface receptor signaling pathway via JAK-STAT / toxic substance binding / Synthesis, secretion, and deacylation of Ghrelin / small molecule binding / Scavenging of heme from plasma / Growth hormone receptor signaling / Recycling of bile acids and salts / positive regulation of tyrosine phosphorylation of STAT protein / cellular response to starvation / response to nutrient levels / platelet alpha granule lumen / cytokine activity / endosome lumen / fatty acid binding / Post-translational protein phosphorylation / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / positive regulation of MAP kinase activity / hormone activity / Cytoprotection by HMOX1 / cytokine-mediated signaling pathway / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / pyridoxal phosphate binding / Platelet degranulation / response to estradiol / protein-folding chaperone binding / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / blood microparticle / copper ion binding / endoplasmic reticulum lumen / Golgi apparatus / endoplasmic reticulum / protein-containing complex / DNA binding / extracellular space / extracellular exosome / extracellular region / identical protein binding / nucleus / metal ion binding / cytoplasm
Similarity search - Function
Somatotropin / Somatotropin/prolactin / Somatotropin hormone, conserved site / Somatotropin hormone family / Somatotropin, prolactin and related hormones signature 1. / Somatotropin, prolactin and related hormones signature 2. / Serum albumin/Alpha-fetoprotein/Afamin / ALB/AFP/VDB / Serum albumin, N-terminal / Serum albumin, conserved site ...Somatotropin / Somatotropin/prolactin / Somatotropin hormone, conserved site / Somatotropin hormone family / Somatotropin, prolactin and related hormones signature 1. / Somatotropin, prolactin and related hormones signature 2. / Serum albumin/Alpha-fetoprotein/Afamin / ALB/AFP/VDB / Serum albumin, N-terminal / Serum albumin, conserved site / Serum albumin-like / Serum albumin family / Albumin domain signature. / Albumin domain profile. / serum albumin / Four-helical cytokine-like, core
Similarity search - Domain/homology
Somatotropin / Albumin
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Eva Johansson (Novo Nordisk A/S)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #2804
Type: atomic / Chi-square value: 2.1025 / P-value: 0.002492

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Sample

SampleName: Human serum albumin in complex with somapacitan / Specimen concentration: 6.3 mg/ml / Entity id: 1469 / 1470
BufferName: 100 mM MES, 140 mM NaCl / pH: 6.5
Entity #1469Name: HSA / Type: protein / Description: Human serum albumin / Formula weight: 66.472 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P02768
Sequence: DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ ...Sequence:
DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ AADKAACLLP KLDELRDEGK ASSAKQRLKC ASLQKFGERA FKAWAVARLS QRFPKAEFAE VSKLVTDLTK VHTECCHGDL LECADDRADL AKYICENQDS ISSKLKECCE KPLLEKSHCI AEVENDEMPA DLPSLAADFV ESKDVCKNYA EAKDVFLGMF LYEYARRHPD YSVVLLLRLA KTYETTLEKC CAAADPHECY AKVFDEFKPL VEEPQNLIKQ NCELFEQLGE YKFQNALLVR YTKKVPQVST PTLVEVSRNL GKVGSKCCKH PEAKRMPCAE DYLSVVLNQL CVLHEKTPVS DRVTKCCTES LVNRRPCFSA LEVDETYVPK EFNAETFTFH ADICTLSEKE RQIKKQTALV ELVKHKPKAT KEQLKAVMDD FAAFVEKCCK ADDKETCFAE EGKKLVAASQ AALGL
Entity #1470Type: protein / Description: somapacitan / Formula weight: 22.119 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: P01241
Sequence:
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS CVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F

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Experimental information

BeamInstrument name: Novo Nordisk A/S Rigaku BioSAXS-2000 / City: Maaloev / 国: Denmark / Type of source: X-ray in house / Wavelength: 0.1542 Å
DetectorName: Pilatus 100K / Pixsize x: 172 mm
Scan
Title: Human serum albumin in complex with somapacitan / Measurement date: Sep 4, 2015 / Cell temperature: 25 °C / Exposure time: 3600 sec. / Number of frames: 6 / Unit: 1/A /
MinMax
Q0.0037 0.645
Distance distribution function P(R)
Sofotware P(R): GNOM 4.5a / Number of points: 127 /
MinMax
Q0.01525 0.1968
P(R) point6 132
R0 139.2
Result
Type of curve: single_conc /
ExperimentalPorod
MW113 kDa126 kDa
Volume-202 nm3

P(R)GuinierGuinier error
Forward scattering, I06.834 6.843 0.02
Radius of gyration, Rg4.12 nm4.06 nm0.02

MinMax
D-13.92
Guinier point6 20

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