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- SASDF35: R16-24 del45-51 human dystrophin fragment (Human dystrophin centr... -

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Basic information

Entry
Database: SASBDB / ID: SASDF35
SampleR16-24 del45-51 human dystrophin fragment
  • Human dystrophin central domain R16-24 del45-51 fragment (protein)
Function / homology
Function and homology information


regulation of muscle system process / regulation of cellular response to growth factor stimulus / regulation of skeletal muscle contraction / syntrophin complex / negative regulation of peptidyl-cysteine S-nitrosylation / regulation of voltage-gated calcium channel activity / synaptic signaling / cardiac muscle cell action potential / dystrophin-associated glycoprotein complex / positive regulation of sodium ion transmembrane transporter activity ...regulation of muscle system process / regulation of cellular response to growth factor stimulus / regulation of skeletal muscle contraction / syntrophin complex / negative regulation of peptidyl-cysteine S-nitrosylation / regulation of voltage-gated calcium channel activity / synaptic signaling / cardiac muscle cell action potential / dystrophin-associated glycoprotein complex / positive regulation of sodium ion transmembrane transporter activity / cell-substrate junction / motile cilium assembly / peptide biosynthetic process / dystroglycan binding / regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / Formation of the dystrophin-glycoprotein complex (DGC) / vinculin binding / costamere / muscle cell development / neuron projection terminus / Striated Muscle Contraction / filopodium membrane / structural constituent of muscle / muscle cell cellular homeostasis / nitric-oxide synthase binding / muscle organ development / myosin binding / maintenance of blood-brain barrier / Non-integrin membrane-ECM interactions / regulation of ryanodine-sensitive calcium-release channel activity / neuron development / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / skeletal muscle tissue development / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / cardiac muscle contraction / response to muscle stretch / positive regulation of neuron differentiation / regulation of heart rate / filopodium / sarcolemma / positive regulation of neuron projection development / structural constituent of cytoskeleton / Z disc / intracellular protein localization / actin binding / protein-containing complex assembly / postsynaptic membrane / cytoskeleton / membrane raft / synapse / cell surface / protein-containing complex / zinc ion binding / nucleus / plasma membrane / cytosol
Similarity search - Function
Dystrophin/utrophin / EF-hand domain, type 1 / EF-hand domain, type 2 / EF hand / EF-hand / : / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Spectrin repeats ...Dystrophin/utrophin / EF-hand domain, type 1 / EF-hand domain, type 2 / EF hand / EF-hand / : / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Spectrin repeats / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Actinin-type actin-binding domain, conserved site / Calponin homology domain / Zinc finger ZZ-type signature. / Calponin homology (CH) domain / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / EF-hand domain pair
Similarity search - Domain/homology
Contact author
  • Raphael Dos Santos Morais (University of Lorraine)

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Structure visualization

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Models

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Sample

SampleName: R16-24 del45-51 human dystrophin fragment
BufferName: NaP 20 mM, NaCl 300 mM, EDTA 1 mM, Glycérol 2% / pH: 7.5
Entity #1562Type: protein
Description: Human dystrophin central domain R16-24 del45-51 fragment
Formula weight: 84.61 / Num. of mol.: 1 / References: UniProt: P11532
Sequence: MSYYHHHHHH DYDIPTTENL YFOGAMGRSL VPRGSLEISY VPSTYLTEIT HVSQALLEVE QLLNAPDLCA KDFEDLFKQE ESLKNIKDSL QQSSGRIDII HSKKTAALQS ATPVERVKLQ EALSQLDFQW EKVNKMYKDR QGRFDRSVEK WRRFHYDIKI FNQWLTEAEQ ...Sequence:
MSYYHHHHHH DYDIPTTENL YFOGAMGRSL VPRGSLEISY VPSTYLTEIT HVSQALLEVE QLLNAPDLCA KDFEDLFKQE ESLKNIKDSL QQSSGRIDII HSKKTAALQS ATPVERVKLQ EALSQLDFQW EKVNKMYKDR QGRFDRSVEK WRRFHYDIKI FNQWLTEAEQ FLRKTQIPEN WEHAKYKWYL KATMQDLEQR RPQLEELITA AQNLKNKTSN QEARTIITDR IERIQNQWDE VQEHLQNRRQ QLNEMLKDST QWLEAKEEAE QVLGQARAKL ESWKEGPYTV DAIQKKITET KQLAKDLRQW QTNVDVANDL ALKLLRDYSA DDTRKVHMIT ENINASWRSI HKRVSEREAA LEETHRLLQQ FPLDLEKFLA WLTEAETTAN VLQDATRKER LLEDSKGVKE LMKQWQDLQG EIEAHTDVYH NLDENSQKIL RSLEGSDDAV LLQRRLDNMN FKWSELRKKS LNIRSHLEAS SDQWKRLHLS LQELLVWLQL KDDELSRQAP IGGDFPAVQK QNDVHRAFKR ELKTKEPVIM STLETVRIFL TEQPLEGLEK LYQEPRELPP EERAQNVTRL LRKQAEEVNT EWEKLNLHSA DWQRKIDETL ERLQELQEAT DELDLKLRQA EVIKGSWQPV GDLLIDSLQD HLEKVKALRG EIAPLKENVS HVNDLARQLT TLGIQLSPYN LSTLEDLNTR WKLLQVAVED RVRQLHE

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Experimental information

BeamInstrument name: SOLEIL SWING / City: Saint-Aubin / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.1033 Å / Dist. spec. to detc.: 1.8 mm
DetectorName: AVIEX PCCD170170 / Type: CCD
Scan
Title: R16-24 del45-51 human dystrophin fragment / Measurement date: Jul 13, 2017 / Unit: 1/A /
MinMax
Q0.0057 0.61
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 296 /
MinMax
Q0.00793799 0.175148
P(R) point1 296
R0 262
Result
Experimental MW: 100 kDa / Type of curve: sec
Comments: SEC-SAXS was performed at 15°C using the following parameters: Column: BioSEC5-500Å (4.6 mm id * 300 mm); Flow rate: 0.3 mL/min; Sample injection concentration: 5 mg/mL; Injection volume: ...Comments: SEC-SAXS was performed at 15°C using the following parameters: Column: BioSEC5-500Å (4.6 mm id * 300 mm); Flow rate: 0.3 mL/min; Sample injection concentration: 5 mg/mL; Injection volume: 70μL. The data were collected through the SEC peak of the protein as a series of several x 0.75 second exposures. The experimental molecular weight was determined from the volume of correlation, Vc.
P(R)Guinier
Forward scattering, I01.065 1.09
Radius of gyration, Rg6.96 nm7.03 nm

MinMax
D-26.2
Guinier point5 17

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