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基本情報
登録情報 | ![]() |
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![]() | Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan.
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機能・相同性 | ![]() growth hormone receptor complex / : / : / bone maturation / prolactin receptor binding / cellular response to xenobiotic stimulus => GO:0071466 / IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor / : / positive regulation of growth / : ...growth hormone receptor complex / : / : / bone maturation / prolactin receptor binding / cellular response to xenobiotic stimulus => GO:0071466 / IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor / : / positive regulation of growth / : / animal organ development / : / regulation of glutamate receptor signaling pathway / regulation of calcium ion import across plasma membrane / aspartic-type endopeptidase inhibitor activity / cellular response to calcium ion starvation / exogenous protein binding / positive regulation of multicellular organism growth / glycosaminoglycan binding / Ciprofloxacin ADME / regulation of potassium ion transmembrane transport / negative regulation of interleukin-17 production / positive regulation of glucose transmembrane transport / negative regulation of dendritic spine maintenance / type 5 metabotropic glutamate receptor binding / cupric ion binding / enterobactin binding / Heme biosynthesis / positive regulation of insulin-like growth factor receptor signaling pathway / growth hormone receptor binding / IgG binding / HDL remodeling / negative regulation of mitochondrial depolarization / Prednisone ADME / growth hormone receptor signaling pathway / negative regulation of calcineurin-NFAT signaling cascade / Heme degradation / negative regulation of T cell receptor signaling pathway / negative regulation of interleukin-2 production / activation of protein kinase activity / Aspirin ADME / Prolactin receptor signaling / negative regulation of amyloid-beta formation / negative regulation of activated T cell proliferation / antioxidant activity / cell surface receptor signaling pathway via JAK-STAT / negative regulation of type II interferon production / toxic substance binding / positive regulation of protein targeting to membrane / Synthesis, secretion, and deacylation of Ghrelin / beta-2-microglobulin binding / Scavenging of heme from plasma / Growth hormone receptor signaling / positive regulation of tyrosine phosphorylation of STAT protein / Recycling of bile acids and salts / neuron projection maintenance / cellular response to starvation / positive regulation of protein localization to plasma membrane / response to nutrient levels / positive regulation of MAP kinase activity / platelet alpha granule lumen / negative regulation of protein phosphorylation / cytokine activity / endosome lumen / fatty acid binding / Post-translational protein phosphorylation / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / protein homooligomerization / negative regulation of DNA-binding transcription factor activity / terminal bouton / hormone activity / Cytoprotection by HMOX1 / cytokine-mediated signaling pathway / cellular response to amyloid-beta / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of peptidyl-tyrosine phosphorylation / pyridoxal phosphate binding / Platelet degranulation / response to estradiol / signaling receptor activity / amyloid-beta binding / protein-folding chaperone binding / nuclear membrane / protease binding / response to oxidative stress / blood microparticle / learning or memory / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endosome membrane / membrane raft / immune response / copper ion binding / endoplasmic reticulum lumen / external side of plasma membrane / dendrite / calcium ion binding / negative regulation of apoptotic process / protein-containing complex binding / cell surface 類似検索 - 分子機能 |
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-モデル
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試料
![]() | 名称: Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan. 試料濃度: 4.5 mg/ml / Entity id: 1462 / 1464 / 1467 / 1475 |
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バッファ | 名称: 100 mM MES, 100 mM NaCl / pH: 6.5 |
要素 #1462 | タイプ: protein / 記述: somapacitan / 分子量: 22.119 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: P01241 配列: FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS CVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F |
要素 #1464 | 名称: HSAopt / タイプ: protein 記述: FcRn binding optimised human serum albumin V418M, T420A, E505G, V547A 分子量: 66.373 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: P02768 配列: DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ ...配列: DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ AADKAACLLP KLDELRDEGK ASSAKQRLKC ASLQKFGERA FKAWAVARLS QRFPKAEFAE VSKLVTDLTK VHTECCHGDL LECADDRADL AKYICENQDS ISSKLKECCE KPLLEKSHCI AEVENDEMPA DLPSLAADFV ESKDVCKNYA EAKDVFLGMF LYEYARRHPD YSVVLLLRLA KTYETTLEKC CAAADPHECY AKVFDEFKPL VEEPQNLIKQ NCELFEQLGE YKFQNALLVR YTKKVPQMSA PTLVEVSRNL GKVGSKCCKH PEAKRMPCAE DYLSVVLNQL CVLHEKTPVS DRVTKCCTES LVNRRPCFSA LEVDETYVPK EFNAGTFTFH ADICTLSEKE RQIKKQTALV ELVKHKPKAT KEQLKAAMDD FAAFVEKCCK ADDKETCFAE EGKKLVAASQ AALGL |
要素 #1467 | 名称: FcRn ECD beta / タイプ: protein 記述: neonatal Fc receptor ectodomain beta-microglogulin part with C-terminal His6 tag 分子量: 12.554 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: P61768 配列: IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDMH HHHHH |
要素 #1475 | 名称: FcRn ECD alpha / タイプ: protein / 記述: neonatal Fc receptor ectodomain alpha-chain / 分子量: 30.375 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: P55899 配列: AESHLSLLYH LTAVSSPAPG TPAFWVSGWL GPQQYLSYNS LRGEAEPCGA WVWENQVSWY WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG ...配列: AESHLSLLYH LTAVSSPAPG TPAFWVSGWL GPQQYLSYNS LRGEAEPCGA WVWENQVSWY WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG RGNLEWKEPP SMRLKARPSS PGFSVLTCSA FSFYPPELQL RFLRNGLAAG TGQGDFGPNS DGSFHASSSL TVKSGDEHHY CCIVQHAGLA QPLRVELESP AKSS |
-実験情報
ビーム | 設備名称: MAX IV I911-4 / 地域: Lund / 国: Sweden ![]() | ||||||||||||||||||||||||||||||
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検出器 | 名称: Pilatus 1M / タイプ: Dectris / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||
スキャン | 測定日: 2015年5月11日 / 保管温度: 25 °C / セル温度: 25 °C / 照射時間: 120 sec. / フレーム数: 1 / 単位: 1/A /
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距離分布関数 P(R) |
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