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- SASDF22: Ternary complex of FcRn ectodomain, FcRn binding optimised human ... -
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Open data
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Basic information
Entry | ![]() |
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![]() | Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan.
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Function / homology | ![]() growth hormone activity / growth hormone receptor complex / : / bone maturation / prolactin receptor binding / cellular response to xenobiotic stimulus => GO:0071466 / IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor / : / positive regulation of growth / : ...growth hormone activity / growth hormone receptor complex / : / bone maturation / prolactin receptor binding / cellular response to xenobiotic stimulus => GO:0071466 / IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor / : / positive regulation of growth / : / animal organ development / positive regulation of activation of Janus kinase activity / regulation of glutamate receptor signaling pathway / regulation of calcium ion import across plasma membrane / aspartic-type endopeptidase inhibitor activity / positive regulation of multicellular organism growth / cellular response to calcium ion starvation / exogenous protein binding / glycosaminoglycan binding / Ciprofloxacin ADME / regulation of potassium ion transmembrane transport / negative regulation of interleukin-17 production / positive regulation of glucose transmembrane transport / negative regulation of dendritic spine maintenance / type 5 metabotropic glutamate receptor binding / cupric ion binding / enterobactin binding / Heme biosynthesis / positive regulation of insulin-like growth factor receptor signaling pathway / growth hormone receptor binding / HDL remodeling / IgG binding / negative regulation of mitochondrial depolarization / Prednisone ADME / growth hormone receptor signaling pathway / negative regulation of calcineurin-NFAT signaling cascade / Heme degradation / negative regulation of interleukin-2 production / negative regulation of T cell receptor signaling pathway / activation of protein kinase activity / Aspirin ADME / Prolactin receptor signaling / negative regulation of amyloid-beta formation / negative regulation of activated T cell proliferation / antioxidant activity / cell surface receptor signaling pathway via JAK-STAT / : / negative regulation of type II interferon production / toxic substance binding / positive regulation of protein targeting to membrane / Synthesis, secretion, and deacylation of Ghrelin / beta-2-microglobulin binding / Scavenging of heme from plasma / Growth hormone receptor signaling / Recycling of bile acids and salts / positive regulation of tyrosine phosphorylation of STAT protein / neuron projection maintenance / cellular response to starvation / response to nutrient levels / platelet alpha granule lumen / negative regulation of protein phosphorylation / cytokine activity / endosome lumen / fatty acid binding / positive regulation of protein localization to plasma membrane / Post-translational protein phosphorylation / positive regulation of receptor signaling pathway via JAK-STAT / positive regulation of MAP kinase activity / growth factor activity / protein homooligomerization / negative regulation of DNA-binding transcription factor activity / hormone activity / Cytoprotection by HMOX1 / terminal bouton / cytokine-mediated signaling pathway / cellular response to amyloid-beta / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of peptidyl-tyrosine phosphorylation / pyridoxal phosphate binding / Platelet degranulation / response to estradiol / signaling receptor activity / amyloid-beta binding / protein-folding chaperone binding / protease binding / nuclear membrane / response to oxidative stress / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / learning or memory / blood microparticle / endosome membrane / immune response / membrane raft / copper ion binding / endoplasmic reticulum lumen / external side of plasma membrane / calcium ion binding / dendrite / protein-containing complex binding / negative regulation of apoptotic process Similarity search - Function |
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Structure visualization
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Downloads & links
-Data source
SASBDB page | ![]() |
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-Related structure data
Similar structure data | Similarity search - Function & homology ![]() |
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External links
Related items in Molecule of the Month |
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-Models
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Sample
![]() | Name: Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan. Specimen concentration: 4.5 mg/ml / Entity id: 1462 / 1464 / 1467 / 1475 |
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Buffer | Name: 100 mM MES, 100 mM NaCl / pH: 6.5 |
Entity #1462 | Type: protein / Description: somapacitan / Formula weight: 22.119 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P01241 Sequence: FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS CVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F |
Entity #1464 | Name: HSAopt / Type: protein Description: FcRn binding optimised human serum albumin V418M, T420A, E505G, V547A Formula weight: 66.373 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P02768 Sequence: DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ ...Sequence: DAHKSEVAHR FKDLGEENFK ALVLIAFAQY LQQCPFEDHV KLVNEVTEFA KTCVADESAE NCDKSLHTLF GDKLCTVATL RETYGEMADC CAKQEPERNE CFLQHKDDNP NLPRLVRPEV DVMCTAFHDN EETFLKKYLY EIARRHPYFY APELLFFAKR YKAAFTECCQ AADKAACLLP KLDELRDEGK ASSAKQRLKC ASLQKFGERA FKAWAVARLS QRFPKAEFAE VSKLVTDLTK VHTECCHGDL LECADDRADL AKYICENQDS ISSKLKECCE KPLLEKSHCI AEVENDEMPA DLPSLAADFV ESKDVCKNYA EAKDVFLGMF LYEYARRHPD YSVVLLLRLA KTYETTLEKC CAAADPHECY AKVFDEFKPL VEEPQNLIKQ NCELFEQLGE YKFQNALLVR YTKKVPQMSA PTLVEVSRNL GKVGSKCCKH PEAKRMPCAE DYLSVVLNQL CVLHEKTPVS DRVTKCCTES LVNRRPCFSA LEVDETYVPK EFNAGTFTFH ADICTLSEKE RQIKKQTALV ELVKHKPKAT KEQLKAAMDD FAAFVEKCCK ADDKETCFAE EGKKLVAASQ AALGL |
Entity #1467 | Name: FcRn ECD beta / Type: protein Description: neonatal Fc receptor ectodomain beta-microglogulin part with C-terminal His6 tag Formula weight: 12.554 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P61768 Sequence: IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDMH HHHHH |
Entity #1475 | Name: FcRn ECD alpha / Type: protein / Description: neonatal Fc receptor ectodomain alpha-chain / Formula weight: 30.375 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P55899 Sequence: AESHLSLLYH LTAVSSPAPG TPAFWVSGWL GPQQYLSYNS LRGEAEPCGA WVWENQVSWY WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG ...Sequence: AESHLSLLYH LTAVSSPAPG TPAFWVSGWL GPQQYLSYNS LRGEAEPCGA WVWENQVSWY WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG RGNLEWKEPP SMRLKARPSS PGFSVLTCSA FSFYPPELQL RFLRNGLAAG TGQGDFGPNS DGSFHASSSL TVKSGDEHHY CCIVQHAGLA QPLRVELESP AKSS |
-Experimental information
Beam | Instrument name: MAX IV I911-4 / City: Lund / 国: Sweden ![]() | ||||||||||||||||||||||||||||||
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Detector | Name: Pilatus 1M / Type: Dectris / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||
Scan | Measurement date: May 11, 2015 / Storage temperature: 25 °C / Cell temperature: 25 °C / Exposure time: 120 sec. / Number of frames: 1 / Unit: 1/A /
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Distance distribution function P(R) |
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Result |
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