+Open data
-Basic information
Entry | Database: PDB chemical components / ID: QOM | ||
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Name | Name: Synonyms: N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide Comment | medication, anticancer, inhibitor*YM | |
-Chemical information
Composition | Formula: C26H23FIN5O4 / Number of atoms: 60 / Formula weight: 615.395 / Formal charge: 0 | ||||||||
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Others | Type: non-polymer / PDB classification: HETAD / Three letter code: QOM / Ideal coordinates details: Corina | ||||||||
History |
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External links | UniChem / BindingDB / Brenda / ChEBI / ChEMBL / ChemicalBook / DailyMed / DrugBank / GtoPharmacology / Nikkaji / PubChem / PubChem_TPharma / SureChEMBL / ZINC / ChemSpider / Wikipedia search / Google search |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Details
-SMILES
ACDLabs 12.01 | CACTVS 3.385 | OpenEye OEToolkits 2.0.7 | |
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-SMILES CANONICAL
CACTVS 3.385 | OpenEye OEToolkits 2.0.7 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-SYSTEMATIC NAME
ACDLabs 12.01 | OpenEye OEToolkits 2.0.7 | ~{ | |
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-PDB entries
Showing all 4 items
PDB-7jur:
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
PDB-7jux:
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
PDB-7m0y:
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib
PDB-8bw9:
Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP