登録情報 データベース : PDB / ID : 9chr 構造の表示 ダウンロードとリンクタイトル Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ without symmetry 要素Potassium voltage-gated channel subfamily H member 2 詳細 キーワード MEMBRANE PROTEIN / Ion channel機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
inward rectifier potassium channel complex / negative regulation of potassium ion export across plasma membrane / regulation of heart rate by hormone / Phase 3 - rapid repolarisation / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / membrane repolarization during action potential / negative regulation of potassium ion transmembrane transport / membrane repolarization during ventricular cardiac muscle cell action potential / membrane repolarization during cardiac muscle cell action potential / potassium ion export across plasma membrane ... inward rectifier potassium channel complex / negative regulation of potassium ion export across plasma membrane / regulation of heart rate by hormone / Phase 3 - rapid repolarisation / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / membrane repolarization during action potential / negative regulation of potassium ion transmembrane transport / membrane repolarization during ventricular cardiac muscle cell action potential / membrane repolarization during cardiac muscle cell action potential / potassium ion export across plasma membrane / voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / C3HC4-type RING finger domain binding / regulation of membrane repolarization / membrane repolarization / positive regulation of potassium ion transmembrane transport / Voltage gated Potassium channels / inward rectifier potassium channel activity / potassium ion homeostasis / membrane depolarization during action potential / ventricular cardiac muscle cell action potential / regulation of potassium ion transmembrane transport / delayed rectifier potassium channel activity / regulation of ventricular cardiac muscle cell membrane repolarization / regulation of heart rate by cardiac conduction / voltage-gated potassium channel activity / potassium ion import across plasma membrane / cardiac muscle contraction / voltage-gated potassium channel complex / potassium ion transmembrane transport / regulation of membrane potential / cellular response to xenobiotic stimulus / scaffold protein binding / transcription cis-regulatory region binding / ubiquitin protein ligase binding / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / cell surface / protein homodimerization activity / identical protein binding / plasma membrane 類似検索 - 分子機能 Potassium channel, voltage-dependent, ERG / : / Potassium channel, voltage-dependent, EAG/ELK/ERG / PAS domain / PAS-associated, C-terminal / PAC domain profile. / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain ... Potassium channel, voltage-dependent, ERG / : / Potassium channel, voltage-dependent, EAG/ELK/ERG / PAS domain / PAS-associated, C-terminal / PAC domain profile. / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / PAS repeat profile. / RmlC-like jelly roll fold / PAS domain / PAS domain superfamily / Ion transport domain / Ion transport protein 類似検索 - ドメイン・相同性 Potassium voltage-gated channel subfamily H member 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 3.5 Å 詳細データ登録者 Lau, C.H.Y. / Hunter, M.J. / Vandenberg, J.I. 資金援助 オーストラリア, 2件 詳細 詳細を隠す組織 認可番号 国 Australian Research Council (ARC) オーストラリア National Health and Medical Research Council (NHMRC, Australia) オーストラリア
引用ジャーナル : to be published タイトル : Potassium dependent structural changes in the selectivity filter of HERG potassium channels著者 : Lau, C.H.Y. / Flood, E. / Hunter, M.J. / WIlliams-Noonan, B.J. / Corbett, K.M. / Ng, C. / Bouwer, J.C. / Stewart, A.G. / Perozo, E. / Allen, T.W. / Vandenberg, J.I. 履歴 登録 2024年7月1日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年8月21日 Provider : repository / タイプ : Initial release