+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 8dmi | ||||||||||||||||||||||||||||||
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タイトル | Lymphocytic choriomeningitis virus glycoprotein | ||||||||||||||||||||||||||||||
要素 |
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キーワード | VIRAL PROTEIN / Viral glycoprotein / arenavirus / LCMV / GP | ||||||||||||||||||||||||||||||
機能・相同性 | 機能・相同性情報 corrinoid adenosyltransferase activity / host cell Golgi membrane / receptor-mediated endocytosis of virus by host cell / host cell endoplasmic reticulum membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / virion membrane / ATP binding ...corrinoid adenosyltransferase activity / host cell Golgi membrane / receptor-mediated endocytosis of virus by host cell / host cell endoplasmic reticulum membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / virion membrane / ATP binding / membrane / metal ion binding 類似検索 - 分子機能 | ||||||||||||||||||||||||||||||
生物種 | Lymphocytic choriomeningitis virus (ウイルス) | ||||||||||||||||||||||||||||||
手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.26 Å | ||||||||||||||||||||||||||||||
データ登録者 | Moon-Walker, A. / Hastie, K.M. / Zyla, D.S. / Saphire, E.O. | ||||||||||||||||||||||||||||||
資金援助 | 米国, スイス, 9件
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引用 | ジャーナル: Cell Chem Biol / 年: 2023 タイトル: Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. 著者: Alex Moon-Walker / Zeli Zhang / Dawid S Zyla / Tierra K Buck / Haoyang Li / Ruben Diaz Avalos / Sharon L Schendel / Kathryn M Hastie / Shane Crotty / Erica Ollmann Saphire / 要旨: The mammarenavirus lymphocytic choriomeningitis virus (LCMV) is a globally distributed zoonotic pathogen that can be lethal in immunocompromised patients and can cause severe birth defects if ...The mammarenavirus lymphocytic choriomeningitis virus (LCMV) is a globally distributed zoonotic pathogen that can be lethal in immunocompromised patients and can cause severe birth defects if acquired during pregnancy. The structure of the trimeric surface glycoprotein, essential for entry, vaccine design, and antibody neutralization, remains unknown. Here, we present the cryoelectron microscopy (cryo-EM) structure of the LCMV surface glycoprotein (GP) in its trimeric pre-fusion assembly both alone and in complex with a rationally engineered monoclonal neutralizing antibody termed 18.5C-M28 (M28). Additionally, we show that passive administration of M28, either as a prophylactic or therapeutic, protects mice from LCMV clone 13 (LCMV) challenge. Our study illuminates not only the overall structural organization of LCMV GP and the mechanism for its inhibition by M28 but also presents a promising therapeutic candidate to prevent severe or fatal disease in individuals who are at risk of infection by a virus that poses a threat worldwide. | ||||||||||||||||||||||||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 8dmi.cif.gz | 271.7 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb8dmi.ent.gz | 177.5 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 8dmi.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 8dmi_validation.pdf.gz | 2.2 MB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 8dmi_full_validation.pdf.gz | 2.2 MB | 表示 | |
XML形式データ | 8dmi_validation.xml.gz | 38.9 KB | 表示 | |
CIF形式データ | 8dmi_validation.cif.gz | 52.5 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/dm/8dmi ftp://data.pdbj.org/pub/pdb/validation_reports/dm/8dmi | HTTPS FTP |
-関連構造データ
関連構造データ | 27539MC 8dmhC M: このデータのモデリングに利用したマップデータ C: 同じ文献を引用 (文献) |
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類似構造データ | 類似検索 - 機能・相同性F&H 検索 |
-リンク
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