- PDB-6oee: Structure of CagT from a cryo-EM reconstruction of a T4SS -
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基本情報
登録情報
データベース: PDB / ID: 6oee
タイトル
Structure of CagT from a cryo-EM reconstruction of a T4SS
要素
Type IV secretion system apparatus protein CagT
キーワード
TRANSLOCASE / T4SS / Secretion / H. pylori
機能・相同性
Cag pathogenicity island protein Cag12 / Cag pathogenicity island protein Cag12 / outer membrane / protein secretion / Prokaryotic membrane lipoprotein lipid attachment site profile. / plasma membrane / CAG pathogenicity island protein 12 / Cag pathogenicity island protein
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
NIH AI118932
米国
National Institutes of Health/National Cancer Institute (NIH/NCI)
CA116087
米国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
GM103310
米国
Other government
1I01BX004447
米国
引用
ジャーナル: Elife / 年: 2019 タイトル: Structure of the Cag type IV secretion system. 著者: Jeong Min Chung / Michael J Sheedlo / Anne M Campbell / Neha Sawhney / Arwen E Frick-Cheng / Dana Borden Lacy / Timothy L Cover / Melanie D Ohi / 要旨: Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Cag T4SS ...Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS assembly, which we describe as three sub-assemblies: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and central stalk. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system assemblies ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.
A: Type IV secretion system apparatus protein CagT B: Type IV secretion system apparatus protein CagT C: Type IV secretion system apparatus protein CagT D: Type IV secretion system apparatus protein CagT E: Type IV secretion system apparatus protein CagT F: Type IV secretion system apparatus protein CagT G: Type IV secretion system apparatus protein CagT H: Type IV secretion system apparatus protein CagT I: Type IV secretion system apparatus protein CagT J: Type IV secretion system apparatus protein CagT K: Type IV secretion system apparatus protein CagT L: Type IV secretion system apparatus protein CagT M: Type IV secretion system apparatus protein CagT N: Type IV secretion system apparatus protein CagT