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- ChemComp-HMT: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methy... -
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Open data
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Basic information
Entry | ![]() | ||
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Name | Name: ( Synonyms: Homoharringtonine; Cephalotaxine; [3(R)]-4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate Comment | anticancer, alkaloid*YM | |
-Chemical information
Composition | |||||||
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Others | Type: NON-POLYMER / PDB classification: HETAIN / Three letter code: HMT / Ideal coordinates details: Corina / Model coordinates PDB-ID: 3G6E | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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-Details
-SMILES
ACDLabs 10.04 | CACTVS 3.341 | OpenEye OEToolkits 1.5.0 | |
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-SMILES CANONICAL
CACTVS 3.341 | OpenEye OEToolkits 1.5.0 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-PDB entries
Showing all 6 items
![](data/pdb/img/3g6e.jpg)
PDB-3g6e:
Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit
![](data/pdb/img/4u4q.jpg)
PDB-4u4q:
Crystal structure of Homoharringtonine bound to the yeast 80S ribosome
![](data/pdb/img/6qzp.jpg)
PDB-6qzp:
High-resolution cryo-EM structure of the human 80S ribosome
![](data/pdb/img/7ewh.jpg)
PDB-7ewh:
Crystal structure of human PHGDH in complex with Homoharringtonine
![](data/pdb/img/8a3d.jpg)
PDB-8a3d:
Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
![](data/pdb/img/8g6j.jpg)
PDB-8g6j:
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2)