登録情報 | データベース: EMDB / ID: EMD-45655 |
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タイトル | Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin |
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マップデータ | Sharpened map 3.19Angstrom |
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試料 | - 複合体: Protein complex of wild type integrin alpha-5 beta-1 with computationally designed protein NeoNectin
- タンパク質・ペプチド: Integrin alpha-5
- タンパク質・ペプチド: Integrin beta-1
- タンパク質・ペプチド: NeoNectin
- リガンド: CALCIUM ION
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
- リガンド: MANGANESE (II) ION
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キーワード | a5B1 / de novo / tissue regeneration / extracellular matrix protein / SIGNALING PROTEIN |
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機能・相同性 | 機能・相同性情報
integrin alpha6-beta1 complex / integrin alpha8-beta1 complex / regulation of collagen catabolic process / integrin alpha3-beta1 complex / integrin alpha5-beta1 complex / integrin alpha7-beta1 complex / integrin alpha10-beta1 complex / integrin alpha11-beta1 complex / positive regulation of glutamate uptake involved in transmission of nerve impulse / myoblast fate specification ...integrin alpha6-beta1 complex / integrin alpha8-beta1 complex / regulation of collagen catabolic process / integrin alpha3-beta1 complex / integrin alpha5-beta1 complex / integrin alpha7-beta1 complex / integrin alpha10-beta1 complex / integrin alpha11-beta1 complex / positive regulation of glutamate uptake involved in transmission of nerve impulse / myoblast fate specification / regulation of inward rectifier potassium channel activity / integrin alpha9-beta1 complex / integrin alpha4-beta1 complex / cardiac cell fate specification / integrin binding involved in cell-matrix adhesion / cell-cell adhesion mediated by integrin / integrin alpha1-beta1 complex / collagen binding involved in cell-matrix adhesion / integrin alpha2-beta1 complex / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / regulation of synapse pruning / reactive gliosis / formation of radial glial scaffolds / cerebellar climbing fiber to Purkinje cell synapse / Other semaphorin interactions / Formation of the ureteric bud / positive regulation of vascular endothelial growth factor signaling pathway / calcium-independent cell-matrix adhesion / integrin alphav-beta1 complex / CD40 signaling pathway / positive regulation of fibroblast growth factor receptor signaling pathway / Fibronectin matrix formation / basement membrane organization / myelin sheath abaxonal region / alphav-beta3 integrin-vitronectin complex / CHL1 interactions / germ cell migration / cardiac muscle cell myoblast differentiation / Laminin interactions / RUNX2 regulates genes involved in cell migration / MET interacts with TNS proteins / leukocyte tethering or rolling / mesodermal cell differentiation / cardiac muscle cell differentiation / cell projection organization / vascular endothelial growth factor receptor 2 binding / Platelet Adhesion to exposed collagen / myoblast fusion / Elastic fibre formation / cell-substrate junction assembly / platelet-derived growth factor receptor binding / axon extension / positive regulation of vascular endothelial growth factor receptor signaling pathway / cell migration involved in sprouting angiogenesis / positive regulation of fibroblast migration / Differentiation of keratinocytes in interfollicular epidermis in mammalian skin / wound healing, spreading of epidermal cells / myoblast differentiation / lamellipodium assembly / positive regulation of cell-substrate adhesion / regulation of spontaneous synaptic transmission / heterotypic cell-cell adhesion / integrin complex / dendrite morphogenesis / Basigin interactions / Molecules associated with elastic fibres / muscle organ development / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / negative regulation of Rho protein signal transduction / cell adhesion mediated by integrin / MET activates PTK2 signaling / negative regulation of vasoconstriction / epidermal growth factor receptor binding / leukocyte cell-cell adhesion / sarcomere organization / Syndecan interactions / positive regulation of wound healing / positive regulation of neuroblast proliferation / maintenance of blood-brain barrier / cell-substrate adhesion / positive regulation of sprouting angiogenesis / homophilic cell adhesion via plasma membrane adhesion molecules / endodermal cell differentiation / TGF-beta receptor signaling activates SMADs / establishment of mitotic spindle orientation / cleavage furrow / glial cell projection / fibronectin binding / cellular response to low-density lipoprotein particle stimulus / negative regulation of anoikis / intercalated disc / negative regulation of neuron differentiation / RHOG GTPase cycle / neuroblast proliferation / ECM proteoglycans / RAC2 GTPase cycle / Integrin cell surface interactions / RAC3 GTPase cycle / cellular defense response / phagocytosis類似検索 - 分子機能 Integrin beta, epidermal growth factor-like domain 1 / Integrin beta epidermal growth factor like domain 1 / Integrin beta subunit, cytoplasmic domain / Integrin beta cytoplasmic domain / Integrin_b_cyt / : / Integrin alpha Ig-like domain 3 / Integrin beta tail domain / Integrin beta subunit, tail / Integrin beta tail domain superfamily ...Integrin beta, epidermal growth factor-like domain 1 / Integrin beta epidermal growth factor like domain 1 / Integrin beta subunit, cytoplasmic domain / Integrin beta cytoplasmic domain / Integrin_b_cyt / : / Integrin alpha Ig-like domain 3 / Integrin beta tail domain / Integrin beta subunit, tail / Integrin beta tail domain superfamily / Integrin_B_tail / Integrin beta subunit, VWA domain / Integrin beta subunit / Integrin beta N-terminal / Integrin beta chain VWA domain / Integrin plexin domain / Integrins beta chain cysteine-rich domain signature. / Integrin beta subunits (N-terminal portion of extracellular region) / EGF-like domain, extracellular / EGF-like domain / Integrin alpha-2 / Integrin alpha Ig-like domain 1 / : / Integrin alpha Ig-like domain 2 / Integrin alpha chain / Integrin alpha beta-propellor / Integrin alpha chain, C-terminal cytoplasmic region, conserved site / Integrins alpha chain signature. / FG-GAP repeat profile. / Integrin alpha (beta-propellor repeats). / FG-GAP repeat / FG-GAP repeat / Integrin domain superfamily / Integrin alpha, N-terminal / PSI domain / domain found in Plexins, Semaphorins and Integrins / von Willebrand factor A-like domain superfamily / EGF-like domain signature 1.類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) / synthetic construct (人工物) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.19 Å |
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データ登録者 | Werther R / Nguyen A / Estrada Alamo KA / Wang X / Campbell MG |
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資金援助 | 米国, 4件 Organization | Grant number | 国 |
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The Pew Charitable Trusts | | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35 GM147414-01 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | P30 CA015704-40; RRID:SCR_022611 | 米国 | Other private | Seattle Cancer Consortium Safeway Inc Pilot Grant | |
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引用 | ジャーナル: To Be Published タイトル: De Novo Design of Integrin alpha5beta1 Modulating Proteins for Regenerative Medicine 著者: Wang X / Guillem-Marti J / Kumar S / Lee DS / Cabrerizo-Aguado D / Werther R / Estrada Alamo KA / Zhao YT / Nguyen A / Kopyeva I / Huang B / Li J / Hao Y / Li X / Brizuela-Velasco A / Murray ...著者: Wang X / Guillem-Marti J / Kumar S / Lee DS / Cabrerizo-Aguado D / Werther R / Estrada Alamo KA / Zhao YT / Nguyen A / Kopyeva I / Huang B / Li J / Hao Y / Li X / Brizuela-Velasco A / Murray AN / Gerben S / Roy A / DeForest CA / Springer T / Ruohola-Baker H / Cooper JA / Campbell MG / Maria Manero J / Ginebra M / Baker D |
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履歴 | 登録 | 2024年7月9日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月17日 | - |
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マップ公開 | 2024年7月17日 | - |
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更新 | 2024年7月17日 | - |
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現状 | 2024年7月17日 | 処理サイト: RCSB / 状態: 公開 |
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