登録情報 | データベース: EMDB / ID: EMD-43139 |
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タイトル | SARS-CoV-2 Spike S2 bound to Fab 54043-5 |
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マップデータ | Final refinement volume, DeepEMhancer sharpened. Used for model building. |
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試料 | - 複合体: Trimeric S2 bound to Fab 54043-5
- 複合体: S2
- タンパク質・ペプチド: Spike protein S2
- 複合体: Fab 54043-5
- タンパク質・ペプチド: 54043-5 Fab Heavy Chain
- タンパク質・ペプチド: 54043-5 Fab Light Chain
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | SARS-CoV-2 spike / S2 subunit / viral fusion / monoclonal antibody / VIRAL PROTEIN |
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機能・相同性 | 機能・相同性情報
Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / symbiont-mediated suppression of host innate immune response / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like ...Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | Severe acute respiratory syndrome coronavirus 2 (ウイルス) / Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.0 Å |
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データ登録者 | Johnson NV / McLellan JS |
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資金援助 | 1件 Organization | Grant number | 国 |
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Not funded | | |
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引用 | ジャーナル: To Be Published タイトル: Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody 著者: Johnson NV / Wall SC / Kramer KJ / Holt CM / Periasamy S / Richardson S / Suryadevara N / Andreano E / Paciello I / Pierleoni G / Piccini G / Huang Y / Ge P / Allen JD / Uno N / Shiakolas AR ...著者: Johnson NV / Wall SC / Kramer KJ / Holt CM / Periasamy S / Richardson S / Suryadevara N / Andreano E / Paciello I / Pierleoni G / Piccini G / Huang Y / Ge P / Allen JD / Uno N / Shiakolas AR / Pilewski KA / Nargi RS / Sutton RE / Abu-Shmais AA / Parks R / Haynes BF / Carnahan RH / Crowe Jr JE / Rappuoli R / Bukreyev A / Ross TM / Sautto GA / McLellan JS / Georgiev IS |
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履歴 | 登録 | 2023年12月14日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月31日 | - |
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マップ公開 | 2024年7月31日 | - |
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更新 | 2024年7月31日 | - |
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現状 | 2024年7月31日 | 処理サイト: RCSB / 状態: 公開 |
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