National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
AI089618
米国
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
AI155804
米国
Howard Hughes Medical Institute (HHMI)
米国
引用
ジャーナル: Proc Natl Acad Sci U S A / 年: 2024 タイトル: Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin. 著者: Joel Finney / Annie Park Moseman / Susan Kong / Akiko Watanabe / Shengli Song / Richard M Walsh / Masayuki Kuraoka / Ryutaro Kotaki / E Ashley Moseman / Kevin R McCarthy / Dongmei Liao / ...著者: Joel Finney / Annie Park Moseman / Susan Kong / Akiko Watanabe / Shengli Song / Richard M Walsh / Masayuki Kuraoka / Ryutaro Kotaki / E Ashley Moseman / Kevin R McCarthy / Dongmei Liao / Xiaoe Liang / Xiaoyan Nie / Olivia Lavidor / Richard Abbott / Stephen C Harrison / Garnett Kelsoe / 要旨: Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both ...Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV and IBV hemagglutinins (HAs) could protect against disease by diverse virus subtypes. Only one reported HA Ab, isolated from a combinatorial display library, protects against both IAV and IBV. Thus, there has been so far no information on the likelihood of finding naturally occurring human Abs that bind HAs of diverse IAV subtypes and IBV lineages. We have now recovered from several unrelated human donors five clonal Abs that bind a conserved epitope preferentially exposed in the postfusion conformation of IAV and IVB HA2. These Abs lack neutralizing activity in vitro but in mice provide strong, IgG subtype-dependent protection against lethal IAV and IBV infections. Strategies to elicit similar Abs routinely might contribute to more effective influenza vaccines.
全体 : Complex of two S1V2-72 Fabs with postfusion HA2
全体
名称: Complex of two S1V2-72 Fabs with postfusion HA2
要素
複合体: Complex of two S1V2-72 Fabs with postfusion HA2
タンパク質・ペプチド: S1V2-72 heavy chain
タンパク質・ペプチド: S1V2-72 light chain
タンパク質・ペプチド: Hemagglutinin
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超分子 #1: Complex of two S1V2-72 Fabs with postfusion HA2
超分子
名称: Complex of two S1V2-72 Fabs with postfusion HA2 / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #2-#3, #1 詳細: Fab fragment generated by proteolytic cleavage of S1V2-72 IgG
由来(天然)
生物種: Influenza B virus (B/Malaysia/2506/2004) (B型インフルエンザウイルス)