登録情報 | データベース: EMDB / ID: EMD-41019 |
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タイトル | Cryo-EM Analysis of AE1 Structure in 100 mM NaHCO3 Buffer: Form1 |
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マップデータ | |
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試料 | - 複合体: AE1
- タンパク質・ペプチド: Band 3 anion transport protein
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
- リガンド: [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
- リガンド: DIUNDECYL PHOSPHATIDYL CHOLINE
- リガンド: CARBONATE ION
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キーワード | Band 3 anion transport protein / anion exchanger 1 (AE1) / band 3 or solute carrier family 4 member 1 (SLC4A1) / TRANSLOCASE |
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機能・相同性 | 機能・相同性情報
pH elevation / Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) / negative regulation of urine volume / Bicarbonate transporters / intracellular monoatomic ion homeostasis / ankyrin-1 complex / plasma membrane phospholipid scrambling / monoatomic anion transmembrane transporter activity / chloride:bicarbonate antiporter activity / solute:inorganic anion antiporter activity ...pH elevation / Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) / negative regulation of urine volume / Bicarbonate transporters / intracellular monoatomic ion homeostasis / ankyrin-1 complex / plasma membrane phospholipid scrambling / monoatomic anion transmembrane transporter activity / chloride:bicarbonate antiporter activity / solute:inorganic anion antiporter activity / bicarbonate transport / bicarbonate transmembrane transporter activity / monoatomic anion transport / chloride transport / chloride transmembrane transporter activity / ankyrin binding / negative regulation of glycolytic process through fructose-6-phosphate / hemoglobin binding / cortical cytoskeleton / erythrocyte development / protein-membrane adaptor activity / chloride transmembrane transport / protein localization to plasma membrane / regulation of intracellular pH / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / cytoplasmic side of plasma membrane / transmembrane transport / Z disc / blood coagulation / basolateral plasma membrane / blood microparticle / protein homodimerization activity / extracellular exosome / membrane / plasma membrane類似検索 - 分子機能 Anion exchange protein 1 / Anion exchange protein / Anion exchange, conserved site / Anion exchangers family signature 1. / Anion exchangers family signature 2. / Band 3 cytoplasmic domain / Band 3 cytoplasmic domain / Phosphotransferase/anion transporter / Bicarbonate transporter, eukaryotic / Bicarbonate transporter-like, transmembrane domain / HCO3- transporter integral membrane domain類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.12 Å |
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データ登録者 | Su CC / Lyu M |
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資金援助 | 米国, 1件 Organization | Grant number | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Cryo-EM structure of the band 3 anion transport protein 著者: Su C-C |
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履歴 | 登録 | 2023年6月8日 | - |
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ヘッダ(付随情報) 公開 | 2024年5月22日 | - |
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マップ公開 | 2024年5月22日 | - |
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更新 | 2024年5月22日 | - |
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現状 | 2024年5月22日 | 処理サイト: RCSB / 状態: 公開 |
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