National Natural Science Foundation of China (NSFC)
91957201
中国
National Natural Science Foundation of China (NSFC)
31821091
中国
National Natural Science Foundation of China (NSFC)
31870833
中国
引用
ジャーナル: Biochem J / 年: 2022 タイトル: Cryo-EM structure of human MG53 homodimer. 著者: Yange Niu / Gengjia Chen / Fengxiang Lv / Rui-Ping Xiao / Xinli Hu / Lei Chen / 要旨: MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a ...MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a 'body' and two 'wings'. Intermolecular interactions are mainly distributed in the 'body' which is relatively stable, while two 'wings' are more dynamic. The overall architecture of MG53 is distinct from those of TRIM20 and TRIM25, illustrating the broad structural diversity of this protein family.