登録情報 | データベース: EMDB / ID: EMD-33551 |
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タイトル | Interface of SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody |
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マップデータ | |
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試料 | - 複合体: Complex of SARS-CoV-2 Spike in complex with R15-F7 and P14-F18-35
- 複合体: SARS-CoV-2 Spike
- タンパク質・ペプチド: Spike protein S1
- 複合体: R15
- タンパク質・ペプチド: heavy chain of R15
- タンパク質・ペプチド: light chain of R15
- 複合体: P14
- リガンド: water
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キーワード | SARS-CoV-2 / spike / bispecific antibody / SYZJ001 / R15-F7 / P14-F8-35 / STRUCTURAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex |
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機能・相同性 | 機能・相同性情報
Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / Attachment and Entry / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / symbiont-mediated suppression of host innate immune response / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like ...Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_virus.gif) Severe acute respiratory syndrome coronavirus 2 (ウイルス) / Homo sapiens (ヒト) / ![](img/tx_mammal.gif) Vicugna pacos (アルパカ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 4.4 Å |
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データ登録者 | Wang L / Zhu L |
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資金援助 | 1件 Organization | Grant number | 国 |
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Not funded | | |
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引用 | ジャーナル: To Be Published タイトル: SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody 著者: Wang L |
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履歴 | 登録 | 2022年6月5日 | - |
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ヘッダ(付随情報) 公開 | 2023年9月6日 | - |
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マップ公開 | 2023年9月6日 | - |
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更新 | 2023年9月6日 | - |
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現状 | 2023年9月6日 | 処理サイト: PDBj / 状態: 公開 |
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