Entry Database : EMDB / ID : EMD-28035 Downloads & linksTitle Cryo-EM structure of the full-length human NF1 dimer Map dataCryo-EM structure of the full-length human NF1 dimer Details SampleComplex : Full-length human NF1Protein or peptide : Isoform I of Neurofibromin Details Keywords GTPase activating protein / Ras signaling / Cancer / SIGNALING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of mast cell apoptotic process / negative regulation of Rac protein signal transduction / regulation of glial cell differentiation / observational learning / Schwann cell migration / negative regulation of Schwann cell migration / vascular associated smooth muscle cell migration / mast cell proliferation / amygdala development / mast cell apoptotic process ... positive regulation of mast cell apoptotic process / negative regulation of Rac protein signal transduction / regulation of glial cell differentiation / observational learning / Schwann cell migration / negative regulation of Schwann cell migration / vascular associated smooth muscle cell migration / mast cell proliferation / amygdala development / mast cell apoptotic process / negative regulation of mast cell proliferation / gamma-aminobutyric acid secretion, neurotransmission / Schwann cell proliferation / vascular associated smooth muscle cell proliferation / glutamate secretion, neurotransmission / negative regulation of Schwann cell proliferation / negative regulation of leukocyte migration / negative regulation of vascular associated smooth muscle cell migration / positive regulation of adenylate cyclase activity / forebrain morphogenesis / negative regulation of neurotransmitter secretion / hair follicle maturation / regulation of cell-matrix adhesion / cell communication / regulation of blood vessel endothelial cell migration / smooth muscle tissue development / camera-type eye morphogenesis / negative regulation of oligodendrocyte differentiation / peripheral nervous system development / phosphatidylcholine binding / myelination in peripheral nervous system / sympathetic nervous system development / myeloid leukocyte migration / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / metanephros development / negative regulation of Ras protein signal transduction / phosphatidylethanolamine binding / collagen fibril organization / regulation of bone resorption / regulation of long-term synaptic potentiation / neural tube development / endothelial cell proliferation / forebrain astrocyte development / artery morphogenesis / pigmentation / regulation of postsynapse organization / negative regulation of neuroblast proliferation / adrenal gland development / regulation of synaptic transmission, GABAergic / negative regulation of protein import into nucleus / regulation of GTPase activity / negative regulation of cell-matrix adhesion / spinal cord development / Rac protein signal transduction / negative regulation of osteoclast differentiation / negative regulation of endothelial cell proliferation / oligodendrocyte differentiation / RAS signaling downstream of NF1 loss-of-function variants / negative regulation of astrocyte differentiation / extrinsic apoptotic signaling pathway via death domain receptors / neuroblast proliferation / negative regulation of MAPK cascade / regulation of angiogenesis / Schwann cell development / negative regulation of stem cell proliferation / negative regulation of fibroblast proliferation / skeletal muscle tissue development / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of MAP kinase activity / positive regulation of vascular associated smooth muscle cell proliferation / positive regulation of endothelial cell proliferation / phosphatidylinositol 3-kinase/protein kinase B signal transduction / GTPase activator activity / extracellular matrix organization / negative regulation of angiogenesis / osteoclast differentiation / regulation of ERK1 and ERK2 cascade / liver development / positive regulation of GTPase activity / negative regulation of cell migration / stem cell proliferation / cognition / long-term synaptic potentiation / negative regulation of protein kinase activity / wound healing / regulation of long-term neuronal synaptic plasticity / visual learning / brain development / cerebral cortex development / osteoblast differentiation / Regulation of RAS by GAPs / protein import into nucleus / positive regulation of neuron apoptotic process / MAPK cascade / presynapse / heart development / cellular response to heat / actin cytoskeleton organization / fibroblast proliferation / regulation of gene expression Similarity search - Function : / PH domain-like / Ras GTPase-activating protein / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases / Ras GTPase-activating domain / Divergent CRAL/TRIO domain ... : / PH domain-like / Ras GTPase-activating protein / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases / Ras GTPase-activating domain / Divergent CRAL/TRIO domain / CRAL-TRIO lipid binding domain profile. / Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) / CRAL-TRIO lipid binding domain / CRAL-TRIO lipid binding domain superfamily / Rho GTPase activation protein / PH-like domain superfamily / Armadillo-type fold Similarity search - Domain/homologyBiological species Homo sapiens (human)Method single particle reconstruction / cryo EM / Resolution : 3.7 Å Details AuthorsDarling JE / Merk A / Grisshammer R / Ognjenovic J Funding support United States, 1 items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) United States
CitationJournal : To Be Published Title : Cryo-EM structure of the full-length human NF1 dimerAuthors : Ognjenovic J / Merk A History Deposition Sep 5, 2022 - Header (metadata) release Sep 20, 2023 - Map release Sep 20, 2023 - Update Sep 20, 2023 - Current status Sep 20, 2023 Processing site : RCSB / Status : Released
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