National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
United States
Citation
Journal: Sci Immunol / Year: 2022 Title: SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines. Authors: John E Bowen / Young-Jun Park / Cameron Stewart / Jack T Brown / William K Sharkey / Alexandra C Walls / Anshu Joshi / Kaitlin R Sprouse / Matthew McCallum / M Alejandra Tortorici / Nicholas ...Authors: John E Bowen / Young-Jun Park / Cameron Stewart / Jack T Brown / William K Sharkey / Alexandra C Walls / Anshu Joshi / Kaitlin R Sprouse / Matthew McCallum / M Alejandra Tortorici / Nicholas M Franko / Jennifer K Logue / Ignacio G Mazzitelli / Annalee W Nguyen / Rui P Silva / Yimin Huang / Jun Siong Low / Josipa Jerak / Sasha W Tiles / Kumail Ahmed / Asefa Shariq / Jennifer M Dan / Zeli Zhang / Daniela Weiskopf / Alessandro Sette / Gyorgy Snell / Christine M Posavad / Najeeha Talat Iqbal / Jorge Geffner / Alessandra Bandera / Andrea Gori / Federica Sallusto / Jennifer A Maynard / Shane Crotty / Wesley C Van Voorhis / Carlos Simmerling / Renata Grifantini / Helen Y Chu / Davide Corti / David Veesler / Abstract: Numerous safe and effective coronavirus disease 2019 vaccines have been developed worldwide that use various delivery technologies and engineering strategies. We show here that vaccines containing ...Numerous safe and effective coronavirus disease 2019 vaccines have been developed worldwide that use various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody responses in humans with enhanced recognition of S and the S subunit relative to postfusion S as compared with vaccines lacking these mutations or natural infection. Prefusion S and S antibody binding titers positively and equivalently correlated with neutralizing activity, and depletion of S-directed antibodies completely abrogated plasma neutralizing activity. We show that neutralizing activity is almost entirely directed to the S subunit and that variant cross-neutralization is mediated solely by receptor binding domain-specific antibodies. Our data provide a quantitative framework for guiding future S engineering efforts to develop vaccines with higher resilience to the emergence of variants than current technologies.
In the structure databanks used in Yorodumi, some data are registered as the other names, "COVID-19 virus" and "2019-nCoV". Here are the details of the virus and the list of structure data.
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)
EMDB accession codes are about to change! (news from PDBe EMDB page)
The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
The EM Navigator/Yorodumi systems omit the EMD- prefix.
Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator
Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.
Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi