- EMDB-19110: CryoEM structure of human GARP-lTGFbeta1 in complex with a Fab fr... -
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基本情報
登録情報
データベース: EMDB / ID: EMD-19110
タイトル
CryoEM structure of human GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody.
マップデータ
Main map: Sharpened map of human GARP-lTGFbeta1 in complex with Fab LHT-22, used for model refinement. Additional map: DeepEMhancer sharpened map, used for model building and map visualization.
試料
複合体: human GAPR-lTGFbeta1 in complex with Fab LHT-22.
establishment of protein localization to extracellular region / cellular response to acetaldehyde / frontal suture morphogenesis / Influenza Virus Induced Apoptosis / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / columnar/cuboidal epithelial cell maturation ...establishment of protein localization to extracellular region / cellular response to acetaldehyde / frontal suture morphogenesis / Influenza Virus Induced Apoptosis / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / columnar/cuboidal epithelial cell maturation / negative regulation of skeletal muscle tissue development / embryonic liver development / regulation of branching involved in mammary gland duct morphogenesis / macrophage derived foam cell differentiation / response to laminar fluid shear stress / regulation of enamel mineralization / regulation of cartilage development / TGFBR2 MSI Frameshift Mutants in Cancer / regulation of striated muscle tissue development / regulatory T cell differentiation / regulation of blood vessel remodeling / tolerance induction to self antigen / regulation of protein import into nucleus / extracellular matrix assembly / negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / negative regulation of hyaluronan biosynthetic process / type III transforming growth factor beta receptor binding / positive regulation of cardiac muscle cell differentiation / myofibroblast differentiation / odontoblast differentiation / positive regulation of odontogenesis / connective tissue replacement involved in inflammatory response wound healing / Langerhans cell differentiation / TGFBR2 Kinase Domain Mutants in Cancer / positive regulation of smooth muscle cell differentiation / positive regulation of exit from mitosis / secondary palate development / negative regulation of macrophage cytokine production / positive regulation of isotype switching to IgA isotypes / positive regulation of mesenchymal stem cell proliferation / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / membrane protein intracellular domain proteolysis / positive regulation of receptor signaling pathway via STAT / retina vasculature development in camera-type eye / heart valve morphogenesis / positive regulation of extracellular matrix assembly / TGFBR3 regulates TGF-beta signaling / mammary gland branching involved in thelarche / bronchiole development / hyaluronan catabolic process / positive regulation of vasculature development / lens fiber cell differentiation / negative regulation of extracellular matrix disassembly / ATP biosynthetic process / positive regulation of branching involved in ureteric bud morphogenesis / type II transforming growth factor beta receptor binding / receptor catabolic process / positive regulation of chemotaxis / TGFBR1 LBD Mutants in Cancer / receptor ligand inhibitor activity / type I transforming growth factor beta receptor binding / negative regulation of biomineral tissue development / germ cell migration / positive regulation of mononuclear cell migration / phospholipid homeostasis / response to salt / endoderm development / negative regulation of myoblast differentiation / negative regulation of cell-cell adhesion mediated by cadherin / positive regulation of vascular permeability / response to cholesterol / oligodendrocyte development / negative regulation of interleukin-17 production / cell-cell junction organization / surfactant homeostasis / deubiquitinase activator activity / phosphate-containing compound metabolic process / transforming growth factor beta binding / response to vitamin D / sprouting angiogenesis / negative regulation of release of sequestered calcium ion into cytosol / positive regulation of chemokine (C-X-C motif) ligand 2 production / aortic valve morphogenesis / digestive tract development / negative regulation of ossification / RUNX3 regulates CDKN1A transcription / positive regulation of fibroblast migration / face morphogenesis / neural tube development / positive regulation of regulatory T cell differentiation / ureteric bud development / negative regulation of cytokine production / Molecules associated with elastic fibres / positive regulation of peptidyl-tyrosine phosphorylation / negative regulation of phagocytosis / positive regulation of epidermal growth factor receptor signaling pathway / lung alveolus development / negative regulation of neuroblast proliferation / cellular response to insulin-like growth factor stimulus 類似検索 - 分子機能
ダウンロード / ファイル: emd_19110.map.gz / 形式: CCP4 / 大きさ: 325 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
注釈
Main map: Sharpened map of human GARP-lTGFbeta1 in complex with Fab LHT-22, used for model refinement. Additional map: DeepEMhancer sharpened map, used for model building and map visualization.
フィルム・検出器のモデル: GATAN K3 (6k x 4k) / 撮影したグリッド数: 2 / 実像数: 13898 / 平均露光時間: 3.37 sec. / 平均電子線量: 61.8 e/Å2 詳細: A total of 6678 untilted movies were collected with a defocus of 0.8 to 2 micrometer. Following untilted data collection, 4020 movies were collected at 16 degree tilt and 3200 movies were ...詳細: A total of 6678 untilted movies were collected with a defocus of 0.8 to 2 micrometer. Following untilted data collection, 4020 movies were collected at 16 degree tilt and 3200 movies were collected at 35 degree tilt, all using similar microscope settings.