ジャーナル: Cell Rep Med / 年: 2024 タイトル: A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. 著者: Chang Liu / Daming Zhou / Aiste Dijokaite-Guraliuc / Piyada Supasa / Helen M E Duyvesteyn / Helen M Ginn / Muneeswaran Selvaraj / Alexander J Mentzer / Raksha Das / Thushan I de Silva / ...著者: Chang Liu / Daming Zhou / Aiste Dijokaite-Guraliuc / Piyada Supasa / Helen M E Duyvesteyn / Helen M Ginn / Muneeswaran Selvaraj / Alexander J Mentzer / Raksha Das / Thushan I de Silva / Thomas G Ritter / Megan Plowright / Thomas A H Newman / Lizzie Stafford / Barbara Kronsteiner / Nigel Temperton / Yuan Lui / Martin Fellermeyer / Philip Goulder / Paul Klenerman / Susanna J Dunachie / Michael I Barton / Mikhail A Kutuzov / Omer Dushek / / Elizabeth E Fry / Juthathip Mongkolsapaya / Jingshan Ren / David I Stuart / Gavin R Screaton / 要旨: BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible ...BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible for many infections in 2023. The global spread and plethora of mutations in BA.2.86 has caused concern that it may possess greater immune-evasive potential, leading to a new wave of infection. Here, we examine the ability of BA.2.86 to evade the antibody response to infection using a panel of vaccinated or naturally infected sera and find that it shows marginally less immune evasion than XBB.1.5. We locate BA.2.86 in the antigenic landscape of recent variants and look at its ability to escape panels of potent monoclonal antibodies generated against contemporary SARS-CoV-2 infections. We demonstrate, and provide a structural explanation for, increased affinity of BA.2.86 to ACE2, which may increase transmissibility.
全体 : BA-2.86 variant SARS-CoV2 S protein complexed with XBB-7 fab.
全体
名称: BA-2.86 variant SARS-CoV2 S protein complexed with XBB-7 fab.
要素
複合体: BA-2.86 variant SARS-CoV2 S protein complexed with XBB-7 fab.
複合体: XBB-7 fab
タンパク質・ペプチド: XBB-7 fab heavy chain
タンパク質・ペプチド: XBB-7 fab light chain
複合体: BA.2.86 variant SARS-CoV2 S protein
タンパク質・ペプチド: Spike glycoprotein,Fibritin
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超分子 #1: BA-2.86 variant SARS-CoV2 S protein complexed with XBB-7 fab.
超分子
名称: BA-2.86 variant SARS-CoV2 S protein complexed with XBB-7 fab. タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: all 詳細: Spike protein recombinantly expressed using sequence of human-derived BA-2.86 variant of SARS-CoV2. XBB7 fab recombinantely expressed from sequenced fab derived from convalescent sera.
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超分子 #2: XBB-7 fab
超分子
名称: XBB-7 fab / タイプ: complex / ID: 2 / 親要素: 1 / 含まれる分子: #2-#3 詳細: XBB-7 fab recombinantely expressed from sequenced fab derived from convalescent sera.
由来(天然)
生物種: Homo sapiens (ヒト)
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超分子 #3: BA.2.86 variant SARS-CoV2 S protein
超分子
名称: BA.2.86 variant SARS-CoV2 S protein / タイプ: complex / ID: 3 / 親要素: 1 / 含まれる分子: #1 詳細: Spike protein recombinantly expressed using sequence of human-derived BA-2.86 variant of SARS-CoV2.
由来(天然)
生物種: Severe acute respiratory syndrome coronavirus 2 (ウイルス)