登録情報 | データベース: EMDB / ID: EMD-16678 |
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タイトル | BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN |
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マップデータ | CryoEM sharpened map BA.2.12.1 Spike complexed with BA.2-07 fab. |
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試料 | - 複合体: BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN
- 複合体: BA.2.12.1 SPIKE GLYCOPROTEIN
- タンパク質・ペプチド: Spike glycoprotein,Fibritin
- 複合体: BA.2-07 FAB Heavy and Light chains
- タンパク質・ペプチド: BA.2-07 FAB HEAVY CHAIN
- タンパク質・ペプチド: BA.2-07 FAB LIGHT CHAIN
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | SARS-CoV2 / spike / glycoprotein / cornovavirus / antibody / fab / BA.4 / BA.5 / BA.2 / BA.2.12.1 / cross-protective / omicron variant / vaccine / therapeutic / complex / neutralising / convalescent sera / viral protein / immune system / BA.2-07 fab / VIRUS |
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機能・相同性 | 機能・相同性情報
virion component / Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion ...virion component / Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / entry receptor-mediated virion attachment to host cell / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Fibritin C-terminal / Fibritin C-terminal region / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus ...Fibritin C-terminal / Fibritin C-terminal region / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_virus.gif) Severe acute respiratory syndrome coronavirus 2 (ウイルス) / Homo sapiens (ヒト) / Enterobacteria phage T4 (ファージ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.0 Å |
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データ登録者 | Duyvesteyn HME / Ren J / Stuart DI / Fry EE |
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資金援助 | 英国, 中国, 4件 Organization | Grant number | 国 |
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Wellcome Trust | 203141/A/16/Z | 英国 | Wellcome Trust | 101122/Z/13/Z | 英国 | Chinese Academy of Sciences | 2018-I2M-2-002 | 中国 | Medical Research Council (MRC, United Kingdom) | MR/N00065X/1 | 英国 |
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引用 | ジャーナル: Res Sq / 年: 2023 タイトル: Isolation of a pair of potent broadly neutralizing mAb binding to RBD and SD1 domains of SARS-CoV-2 著者: Duyvesteyn HME / Screaton G / Ren J / Stuart DI / Fry EE |
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履歴 | 登録 | 2023年2月10日 | - |
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ヘッダ(付随情報) 公開 | 2023年7月5日 | - |
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マップ公開 | 2023年7月5日 | - |
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更新 | 2023年7月5日 | - |
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現状 | 2023年7月5日 | 処理サイト: PDBe / 状態: 公開 |
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