Entry | Database: PDB / ID: 8svy |
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Title | MBP-Mcl1 in complex with ligand 10 |
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Components | Maltose/maltodextrin-binding periplasmic protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera |
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Keywords | SIGNALING PROTEIN / Myeloid cell leukemia 1 / Mcl-1 / B-cell lymphoma 2 / Bcl-2 / BH3 mimetic / Protein-protein interaction / Modulator / Apoptosis / Cancer / Leukemia / Myeloma / Lymphoma |
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Function / homology | Function and homology information
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH domain binding / BH3 domain binding / negative regulation of anoikis / carbohydrate transmembrane transporter activity ...positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH domain binding / BH3 domain binding / negative regulation of anoikis / carbohydrate transmembrane transporter activity / protein transmembrane transporter activity / maltose binding / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / maltose transport / maltodextrin transmembrane transport / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / intrinsic apoptotic signaling pathway in response to DNA damage / Signaling by ALK fusions and activated point mutants / outer membrane-bounded periplasmic space / Interleukin-4 and Interleukin-13 signaling / regulation of apoptotic process / mitochondrial outer membrane / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / mitochondrion / nucleoplasm / membrane / nucleus / cytosol / cytoplasmSimilarity search - Function Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 ...Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding proteinSimilarity search - Domain/homology alpha-maltose / Chem-WUC / Maltose/maltodextrin-binding periplasmic protein / Induced myeloid leukemia cell differentiation protein Mcl-1Similarity search - Component |
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Biological species | Escherichia coli (E. coli) Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.47 Å |
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Authors | Miller, B.R. / Shaffer, P. |
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Funding support | 1items Organization | Grant number | Country |
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Other private | | |
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Citation | Journal: Acs Med.Chem.Lett. / Year: 2023 Title: Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1. Authors: Demin, S. / Peschiulli, A. / Velter, A.I. / Vos, A. / De Boeck, B. / Miller, B. / Rombouts, F.J.R. / Reuillon, T. / Lento, W. / Blanco, M.D. / Jouffroy, M. / Steyvers, H. / Bekkers, M. / ...Authors: Demin, S. / Peschiulli, A. / Velter, A.I. / Vos, A. / De Boeck, B. / Miller, B. / Rombouts, F.J.R. / Reuillon, T. / Lento, W. / Blanco, M.D. / Jouffroy, M. / Steyvers, H. / Bekkers, M. / Altrocchi, C. / Pietrak, B. / Koo, S.J. / Szewczuk, L. / Attar, R. / Philippar, U. |
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History | Deposition | May 17, 2023 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 9, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 22, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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